DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment plx and EVI5L

DIOPT Version :10

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:NP_001153416.1 Gene:EVI5L / 115704 HGNCID:30464 Length:805 Species:Homo sapiens


Alignment Length:651 Identity:162/651 - (24%)
Similarity:278/651 - (42%) Gaps:97/651 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   822 VVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA----- 881
            :.:|:...||.......:|...|....:..:.:..||          |.::|.:|.:|:|     
Human     1 MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELEL----------LAKLEEQNRLLEADSKSM 55

  Fly   882 -------RQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPR 939
                   |.:.:.|.........:...::.....|.:|  .|..:...::..|:|...||.|:|.
Human    56 RSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRI--ANEWEEWRRRKEKLLKELIRKGIPH 118

  Fly   940 SKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPL 1004
            ..|..||..|.....|   ||..:        |..|||..:..:..|..|:.||:|.|:|:|...
Human   119 HFRAIVWQLLCSATDM---PVKNQ--------YSELLKMSSPCEKLIRRDIARTYPEHEFFKGQD 172

  Fly  1005 GLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMK 1069
            .|||..|||::||||::|.|:|||||..||.|:||:...|..:|.:...||....:|..:.|.|.
Human   173 SLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMA 237

  Fly  1070 KFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSD 1134
            :..|.:||...::::.||||...........::||:.|.||:|.:.|||....||||:...|..:
Human   238 ELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLE 302

  Fly  1135 VIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEY 1199
            ::|:..:|||.|::.:|:..| .|.:..|.:.|:|....:|.::::           |..|:|:|
Human   303 IVFRVGLALLQVNQAELMQLD-MEGMSQYFQRVIPHQFDSCPDKLV-----------LKAYQVKY 355

  Fly  1200 NV-----LQEEITTTNHHLEM-----LNREKTQNQHLEQQLQFAQSSIAQL-------ETTRSSQ 1247
            |.     |::|....... ||     :.|.:|:|:.|:|:::..:...|.|       :.||:.:
Human   356 NPKKMKRLEKEYAAMKSK-EMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRAQE 419

  Fly  1248 -------QAQITTLQSQVQSLELTIQTLGRYVGQLVE--HNPDL----------ELPNEVRRMLQ 1293
                   :.::..::.|..|....:|.....:.||.|  .||.|          ||.....|..:
Human   420 AEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETE 484

  Fly  1294 QLDDLDRQRRKPIFTERKIGKSVSVN--SHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLR 1356
            .|..|...:.|.:..|::.......|  :.|...||.| ::.|...:.|.::.|.:    .::|.
Human   485 TLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKAL-KVREGQAVASTRELKLQ----LQELS 544

  Fly  1357 QQQQQHRLNGGGQSSN-----VGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVA 1416
            ...|.|...||....:     |||........|.......|..|.:.| ::.||:..:|:.:.:.
Human   545 DTWQAHLARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQ-RVVELETQDHIHRNLL 608

  Fly  1417 N 1417
            |
Human   609 N 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967
DUF3350 831..880 CDD:463365 8/48 (17%)
TBC 933..1152 CDD:214540 78/218 (36%)
COG4372 <1190..>1353 CDD:443500 42/200 (21%)
EVI5LNP_001153416.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..75 3/25 (12%)
TBC 112..320 CDD:214540 78/218 (36%)
Smc <363..>762 CDD:440809 53/254 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..805
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.