Protein Alignment plx and TBC1D8

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001317277.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1155
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 131/586 - (22%)
• Similarity: 215/586 - (36%)
• Gaps: 169/586 - (28%)

  Fly   933 IRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKH-------LTEHQHAIFIDL 990
            :..|:|.|.||.:|...::      |..|....|.:   |..|::.       :||.   |..||
Human   517 VAMGIPESLRGRLWLLFSD------AVTDLASHPGY---YGNLVEESLGKCCLVTEE---IERDL 569

  Fly   991 GRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLM 1055
            .|:.|.|..:::..|:.  :|..:|.||:..:|::||||.:..:..||||:..|..:|.||..:.
Human   570 HRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVC 632

  Fly  1056 FRRNMRTKYLPDMKKFQL---QLYQ--LSRLVKDHLPDLYVWLDQNDVSP-TLYAAPWILTVFSS 1114
            .|      .|||....::   |:.|  ...|:|.|||:|...:  ||:|. ...:..|.||:|.|
Human   633 ER------MLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHM--NDLSALASVSLSWFLTLFLS 689

  Fly  1115 QFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL-AKDNFEEIM------DYLKTV----V 1168
            ..||.....|.|..|.:....||:..:|:|..:.:.|. :||:.:.:|      |::|..    .
Human   690 IMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGP 754

  Fly  1169 PKMEHTCMEQIMKLVFSMD-------------------IGKQLAE------YKVEYNVLQEEITT 1208
            |...|...       ||.|                   .|.|..|      ||....|||....|
Human   755 PVGSHHAF-------FSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDT 812

  Fly  1209 TNHHL-------------------EMLNREKTQNQHLEQQLQFA-----------QSSIAQLETT 1243
            |..::                   ::..||...:.:.||....|           |..|...:..
Human   813 TKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPMASRHDPSRPYAEQYRIDARQFA 877

  Fly  1244 RSSQQAQITTLQSQVQSL-ELTIQTLGRYVGQLVE-----------HNPDLELPNEVRRMLQQL- 1295
            ...|.....|..:..:.| |.|.:.|...:.||:|           :|.::   ||..::|.:|
Human   878 HLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFKAFVSCLDIMYNGEM---NEKIKLLYRLH 939

  Fly  1296 -------DDLDRQR--RKPIF-TERKI------GKSVSVNSHLGFPLKVLEELTERDELGSPQKQ 1344
                   :|.|.|.  |.|:. |.|.:      |.:|.....|...:|.|.:..::.|...|:..
Human   940 IPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDAVDYQKQLKQMIKDLAKEKDKTEKELPKMS 1004

  Fly  1345 KKEKTPF----FEQLRQQQQQHRL----------------------NGGGQSSNVGE---SGSPT 1380
            ::|...|    :....:..:::.|                      :.|..|...||   :.:|:
Human  1005 QREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRASAPS 1069

  Fly  1381 P 1381
            |
Human  1070 P 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365
		TBC	933..1152	CDD:214540	66/231 (29%)
		COG4372	<1190..>1353	CDD:443500	46/231 (20%)
TBC1D8	NP_001317277.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	520..726	CDD:214540	66/227 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1085		6/25 (24%)