Protein Alignment plx and Tbc1d10c

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_848765.2
• Gene: Tbc1d10c / 108995
• MGIID: 1922072
• Length: 444
• Species: Mus musculus
• Alignment Length: 498
• Identity: 123/498 - (24%)
• Similarity: 190/498 - (38%)
• Gaps: 127/498 - (25%)

  Fly   826 SKGLDSEVPTEFLSPMRKPAKRG--KRDAAELRELWRTA--IRQTIMLNRMETENAMLQARQNEN 886
            |.|.|||:...  ||.|:..:.|  ..::.|||....:|  |||                    .
Mouse    19 SLGSDSELSGP--SPYRQADRYGFIGGNSGELRLCQPSADLIRQ--------------------R 61

  Fly   887 ELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFL-- 949
            |:|.:::..            .||:.:.|...::      |:   ..|.|:|.:.|...|..|
Mouse    62 EMKWVEMTL------------HWEKTMSRRYKKV------KI---QCRKGIPSALRARCWPLLCG 105

  Fly   950 ---AEQHSMNT------APVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLG 1005
               .::::..|      ||.|         |..|         ..|..||.|.||.|:.:..|.|
Mouse   106 ARMCQKNNPGTYQELAAAPGD---------PQWM---------ETIGRDLHRQFPLHEMFVSPQG 152

  Fly  1006 LGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKK 1070
            .||..|..:||||::..||.||||..|.:..|||:|.....:|..|..:. ...:...|.|.|:.
Mouse   153 HGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQIC-EVYLPGYYGPHMEA 216

  Fly  1071 FQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDV 1135
            .||.......|::..||.:|..|.|..|.|.||...|.|.:|:...|...|.|::|....|.:.|
Mouse   217 VQLDAEVFMALLRRQLPRVYKHLQQVGVGPLLYLPEWFLCLFTRSLPFPTVLRIWDAFLSEGAKV 281

  Fly  1136 IFKFAIALLSV---HKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKV 1197
            :|:..:.|:.:   ..:|..|.....|.:..|:.:.|       .|:.:.||.    .|:....:
Mouse   282 LFRVGLTLMRLALGTVEQRTACPGLLETLGALRAIPP-------TQLQEEVFM----SQVHSVTL 335

  Fly  1198 EYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLE 1262
            ...|||:||                      ::|.||.| ..|.......||::...|:..:|.:
Mouse   336 SERVLQQEI----------------------RIQLAQLS-KSLPGPAPLPQARLPGAQAIFESQQ 377

  Fly  1263 LTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKP 1305
            |        .|  |..:...|:|   |.::|..::....||||
Mouse   378 L--------AG--VRESTKPEIP---RIVVQPPEEPKPPRRKP 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	13/52 (25%)
		TBC	933..1152	CDD:214540	68/232 (29%)
		COG4372	<1190..>1353	CDD:443500	26/116 (22%)
Tbc1d10c	NP_848765.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		6/14 (43%)
		TBC	87..292	CDD:214540	67/223 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..444		8/28 (29%)
		Interaction with calcineurin. /evidence=ECO:0000250	404..444		4/4 (100%)