Protein Alignment plx and sgsm1b

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_073770421.1
• Gene: sgsm1b / 100535556
• ZFINID: ZDB-GENE-091117-39
• Length: 1497
• Species: Danio rerio
• Alignment Length: 1280
• Identity: 239/1280 - (18%)
• Similarity: 418/1280 - (32%)
• Gaps: 416/1280 - (32%)

  Fly    91 KSSAGQTSSSSAVASSMGG--------AASSSLTGNGLRHTLTASTSYGSLSSSAACAY----QL 143
            |||.   ||.|...||.||        .|...|....::|.:.:...||.|   |.|.:    :.
Zfish   441 KSSC---SSCSQNGSSDGGLPNGCNHDRAPLKLLCETMKHQIISRAFYGWL---AYCRHLSTVRT 499

  Fly   144 QLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVEEMAELMHQMRDPAHTL 208
            .|.....|:..:|....:.:|.::..|:          ..:|.:|.|.|| .||:..:     ..
Zfish   500 HLSALVNATIVEPDIPYDAKGGLSADVW----------KSFLQDCSAYEE-EELLRLV-----YY 548

  Fly   209 GGSVGSIPQT----LIGGGGGSHGNSNGALNGIHAT--PATNLKMSEAMRNAQHDTSPN------ 261
            ||...|:.:.    |:|     |         .|.|  |....::.|.:|.....|...
Zfish   549 GGVEPSLRKEVWPFLLG-----H---------YHFTMSPEERKEVDEQIRACYEQTMSEWLGCEA 599

  Fly   262 -----------PVSSKMKASKSYTHGLSSSSGTVNIPTSTSA----QSNLSLLADISPNHTHFFE 311
                       ...:|..:..|...| |....|::..:|.|:    ||:....:| |.:.|..|
Zfish   600 IVRQREKEQHAAALAKCASGASVDRG-SRQDSTISTDSSQSSNSDKQSHAGSHSD-SNSSTQVF- 661

  Fly   312 VMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDL 376
                |.            :|:..|                           ||::|
Zfish   662 ----GS------------VDEVDP---------------------------IESEP--------- 674

  Fly   377 KEEDEEEQEQ-------------HKGHDDSQD-------SQAKPLVQLQLTGAEEGAAP----RP 417
            |.:||:.|.:             ..||..|::       |...|..:...|...:|..|    :|
Zfish   675 KPKDEKPQPKIPNGALPNCTSSPDSGHPSSRNFSVTSAMSDCSPSTEETSTQESKGNQPDIEEKP 739

  Fly   418 LEDNKENKSPEK---RPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPT----PPRD 475
            .|:..||.|..:   :..:..|::.:|...|.|     .|...|::.   .::|.||    |..|
Zfish   740 KEEQPENSSTTQNTDKAAITTQNKSKLQTSETS-----RAETDQIKD---AISKNPTNLSEPKED 796

  Fly   476 Q-GVGTGTASASAGPSQLHPNYAMDNIPKQRDRSA----SQGCIPPYVEQNRTMVFLVGRCDLRL 535
            : ..|..|..:.....::.|:    ..|.:..||:    ::...|               ..|.:
Zfish   797 EVNAGAETRKSEVNKCEVQPS----RDPAEESRSSESKQAEDADP---------------VSLSI 842

  Fly   536 ISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQS---EHVCDDIVAAI 597
            :..|.|                 ..:....|:   ::|.|.      |.|.   |...:|    :
Zfish   843 VDEDTK-----------------SNTEQEIGL---KVNEDS------KSQQSAPESTPED----V 877

  Fly   598 AQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTD-------VEGLSEKKTQALILRRIETLSDD 655
            ..:.:..:|...||:|.:            |:..|       .|..||..|.:   :.:.:.|:.
Zfish   878 KTSQNLSSESNTKQETSL------------KVSEDSKCQPSAPESTSEAMTTS---QNLSSESNT 927

  Fly   656 EQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHD---TAENRSEFLNQYLGGSTI 717
            |||           |...|.|.::         |:........:   |::|.|
Zfish   928 EQE-----------TGLKVNEDSK---------CQPSAPESTSEDMKTSQNIS------------ 960

  Fly   718 FMKAKRSLTNSFDNLLKRKPSKDDIAVP---------SHNLRD-----------IREGS-AEPLG 761
                ..|.|.....|...|.||.:.:.|         |.||..           :.|.| .:|..
Zfish   961 ----SESNTEQETGLKVNKDSKSEQSAPKSTPEHMKTSQNLLSELNMEQATGLKVNEDSKCQPSA 1021

  Fly   762 TQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVG-------NSPKEAETHQGSWRQAIL 819
            .:|.||..::..|....|.:.:.|.           :||.       ::||....|..:.:..:.
Zfish  1022 PESTPEAMKTSQNISSESNTQQETG-----------LKVNKDSKSEQSAPKSTPEHMKTSQNLLS 1075

  Fly   820 NSVVTPSKGL----DSE----VPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIML----NRM 872
            ...:..:.||    ||:    .|...|..|    |..:..::..:.:.:|| .|||..    ||
Zfish  1076 ELNMEQATGLKVNEDSKCQPSAPESTLDDM----KTSQNLSSGPQNVPQTA-PQTISWDSEHNR- 1134

  Fly   873 ETENAMLQARQNENE-------LKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLG 930
             ..:.:.|..::|:|       |.:...|..:..|...::.|....::.. |::....:.|..|.
Zfish  1135 -ARSIIKQMTESESESCGPLTSLSKPSPDMSDDSPSALEMEEIPSSVVYM-SSETSMCRTPLTLA 1197

  Fly   931 HAIRTGV---PRSKRGDVWTFLAEQHSMNTAPVDT------------KRFP-------------- 966
            ..:...:   .:|..|.....|..:..:||.|..|            ..||
Zfish  1198 RPVAPCIAAGEKSPMGMPALELCMEPGVNTTPEGTDSALSEEEPEMDNLFPKPDSLAVTGDKNDI 1262

  Fly   967 -----NFNTPYHMLLKHL-TEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPEL 1025
                 :..|.|...|..| |.:.|.|..|:.|...|: :|..|..|.:|.  |::.:|.....::
Zfish  1263 ASPVSSIGTTYSQELVDLYTLNLHRIDKDVQRCDRNY-WYFTPANLEKLR--NIMCSYVWQHLDI 1324

  Fly  1026 GYCQGL-GFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            ||.||: ..:..:|::..|||.:|.....||.|.|....:...|......:..|.:::...|.:|
Zfish  1325 GYVQGMCDLLAPLLVILDDEAMAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFEL 1389

  Fly  1090 YVWLDQN-DVSPTLYAAPWILTVFSSQFPLGFVARVFDLL----FLESSDVIFKFAIALLSVHKQ 1149
               :.|| |.:...:...|.|..|..:.....|..|::.:    :..|...:...|:||:.:::.
Zfish  1390 ---MQQNGDYTHFYFCYRWFLLDFKREMVYDDVFSVWETIWAARYASSEHFVLFIALALVELYRD 1451

  Fly  1150 QLLAKD-NFEEIMDYLKTV-----VPKMEHTCMEQIMKLVFSMDI 1188
            .:|..: :|.:|:.:...:     |||:          ||.:.|:
Zfish  1452 IILENNMDFTDIIKFFNEMAERHDVPKL----------LVMARDL 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	55/338 (16%)
		DUF3350	831..880	CDD:463365	12/56 (21%)
		TBC	933..1152	CDD:214540	54/259 (21%)
		COG4372	<1190..>1353	CDD:443500
sgsm1b	XP_073770421.1	None