Protein Alignment plx and tbc1d4

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_004911887.2
• Gene: tbc1d4 / 100379738
• XenbaseID: XB-GENE-980839
• Length: 1274
• Species: Xenopus tropicalis
• Alignment Length: 1257
• Identity: 390/1257 - (31%)
• Similarity: 604/1257 - (48%)
• Gaps: 289/1257 - (22%)

  Fly   233 ALNGIHATPATNL------KMSEAMRNAQH--------DTSPNPVSSKMKASKSYTHGLSSSSGT 283
            ||||.:|..|..:      .:|..:.|:|.        .|.|:...|:|..   :....::....
 Frog    89 ALNGANANSAVFIFEHKAQHISRFIHNSQDPSYFAYLIKTQPDNPESEMAC---HVFKANTPRQV 150

  Fly   284 VNIPTSTSAQSNLSLLADISP--------NHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAY 340
            .:|.:|....|.::|..|..|        .::..|||:|.||:.::.|:.|:|.:||.:.||..:
 Frog   151 SDIISSIRQVSKVALKEDSKPCRDSEDAFYNSQKFEVLYCGKVVIANKKAPSTLVDDCIEKFSQH 215

  Fly   341 DAQRLRLLQNRKMSLSSE----GGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPL 401
            :.|||:.|..::.:..|.    ..:.:...||......|.:.......|.|.|. .:..||:
 Frog   216 ERQRLKSLNEQQSAECSTDFSLAEIDVPGSPSDMFLEQDSENNFIPSSEHHSGM-FTVGSQS--- 276

  Fly   402 VQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIV 466
               .|.|:......|.|||:......|.|                            ....:|.:
 Frog   277 ---NLIGSRVTFPERILEDSGFEDQQEFR----------------------------TRCSSVTI 310

  Fly   467 NKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDN--IPKQRDRSASQGCIPPYVEQNRTMVFLVG 529
            :|:                           |.||  .|::|..||.....|...|:||||:|.||
 Frog   311 HKR---------------------------AQDNKIQPRRRHASAPSHVQPTDSEKNRTMLFQVG 348

  Fly   530 RCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDG---YIGYVFKCQSEHVCD 591
            |.::.|||||.|.|.|.|:|||::||..|.|.:||||::|||....|   ||.|||:|.||.:.:
 Frog   349 RFEINLISPDTKTVELEKNFKDISSCSQGIKHIDHFGLVCRECVEPGINQYICYVFQCASEALVE 413

  Fly   592 DIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDE 656
            :::..:.|||.|.|..:..: |||..||.|||...||||..:|||...:.:.:|.:::..|:|:|
 Frog   414 EVMLTLKQAFSTAAALQSAK-TQIKLCEACPMHALHKLCERIEGLYPPRAKLVIQKQLSLLTDNE 477

  Fly   657 QEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVH--------------DTAENRSEF 707
            |..::.:....:.|:.  .|:|:.:::.||..||::|:.|||              :.|.....|
 Frog   478 QADIFERVQKMKATSD--QEENELVILHLRQLCETKQKTHVHIGEVQQNLPCNTVPENAAPSGRF 540

  Fly   708 LNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSK-------DDIAVPSHNLRDIREGS--------- 756
            ....|..     |||:|||:|.:|:..|..:|       .|.....::....::||
 Frog   541 KLDILKN-----KAKKSLTSSLENIFSRGTNKMRGRLGSMDSFERCNSFTSDKDGSPGDSPPATP 600

  Fly   757 -AEPLGTQSPP-----------------------EGFR--------------------SRSNTVG 777
             :.|:.:..||                       .|.|                    |.:|.||
 Frog   601 PSSPVSSSCPPFPEEDPDSPKVRRRAHTFSHPTSSGKRRITFPDSKSPSARFPLQRQNSLANDVG 665

  Fly   778 ----------------ASPSSKPTAEQLKSPMMDIFIKVG--------NSPK-EAE--------- 808
                            :|.||.|::....|.:.:.:...|        ::|| |:|
 Frog   666 QSSPVPIARRFRTESESSSSSLPSSFSAPSFLKNFYQNSGRHVPQSENDTPKSESEGRRRTFSSC 730

  Fly   809 -------------THQGSWRQAILNSVVTP---------SKG---LDSEVPTEFLSPMRKPA--- 845
                         .|:.||||.|...|.:|         .||   ::..:|   |||: .||
 Frog   731 SNDSLNASGSCLIPHRISWRQRIFLRVASPMTNSLSDMQHKGQLDVNDLLP---LSPL-PPAMEE 791

  Fly   846 ---------------KRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDY 895
                           ..|||.:.:.:.||:.||.|.|:|.|||.||..|:|.::|.:.:::||||
 Frog   792 DPLAALLQAEDSALQSEGKRSSEDFQNLWKKAIHQQILLLRMEKENMKLEASRDELQSRKVKLDY 856

  Fly   896 EEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPV 960
            ||:..|.|:::..|::.:... |:|  :.|.:.:...::.|||:.|||::|.||:.|:.:.
 Frog   857 EEVGLCQKEVLNLWDKKLNCR-TKI--RFDMEEIFATLKEGVPKGKRGEIWQFLSVQYRLR---- 914

  Fly   961 DTKRFPNFNTP----YHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSIL 1021
              .|.|:...|    |:.|||.||..||||.:|||||||.|.::...||.|||||:|||||||:|
 Frog   915 --HRLPSKQQPSDVSYNDLLKQLTAQQHAILVDLGRTFPTHPYFSAQLGAGQLSLYNLLKAYSLL 977

  Fly  1022 DPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHL 1086
            |.|:|||||:.|:.||||||..|..:|::||.||:....|.:|.|||...|:|:||||||:.|:.
 Frog   978 DKEVGYCQGISFVAGVLLLHMSEQQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYH 1042

  Fly  1087 PDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151
            .|||..|::|:::|:||||||.||:|:|||||||||||||::||:.::||||.|:.|||..:..:
 Frog  1043 RDLYNHLEENEINPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALCLLSNSEALI 1107

  Fly  1152 LAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTN------ 1210
            :|:|:||.|:|:||:::|:|.:..||:|:..||.|||.|||..|:|||:|:.:|:...:
 Frog  1108 MARDSFESIVDFLKSMIPEMTNETMEKIITQVFEMDISKQLHAYEVEYHVINDEMLEASIPSDDN 1172

  Fly  1211 ---HHLEMLNRE-KTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLE-------LT 1264
               |.||..|.: |.||..|.::||.|.:.|..||:...:..::...|::.|:|:|       ..
 Frog  1173 ESFHKLEKSNNQLKRQNMDLLEKLQVAHTKIQSLESNVENILSRENKLRNVVRSMEEERSAYQNV 1237

  Fly  1265 IQTLGRYVGQLVEHNPDLELPN 1286
            .:.:.:||...|..:.:|.|.|
 Frog  1238 FELMKKYVPTNVLTDCELLLKN 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	88/316 (28%)
		DUF3350	831..880	CDD:463365	21/66 (32%)
		TBC	933..1152	CDD:214540	118/222 (53%)
		COG4372	<1190..>1353	CDD:443500	33/114 (29%)
tbc1d4	XP_004911887.2	PH-like	26..173	CDD:473070	19/86 (22%)
		PTB_TBC1D1_like	176..423	CDD:269967	86/308 (28%)
		DUF3350	788..841	CDD:463365	16/52 (31%)
		TBC	894..1108	CDD:214540	118/219 (54%)