Protein Alignment plx and evi5l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_031753513.1
• Gene: evi5l / 100145757
• XenbaseID: XB-GENE-5723194
• Length: 809
• Species: Xenopus tropicalis
• Alignment Length: 642
• Identity: 159/642 - (24%)
• Similarity: 268/642 - (41%)
• Gaps: 161/642 - (25%)

  Fly   771 SRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPT 835
            |.||.  ||||..|....|.:       .|..||.::|.
 Frog     8 SLSNM--ASPSLSPDESSLSA-------AVSISPSDSEN-------------------------- 37

  Fly   836 EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIV- 899
              |||          |..||             |:::|.:|.:|:|  :...|:.:.......|
 Frog    38 --LSP----------DELEL-------------LSKLEEQNRLLEA--DSKSLRSVTGPCRSTVT 75

  Fly   900 -----PCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAP 959
                 |.|:...|.|.:||  ...:...::..|:|...||.|:|...|..||..|.....|   |
 Frog    76 SPGPSPLDQDSWELWGRII--THWEEWTRRKEKLLKELIRKGIPHHFRAMVWQMLCNATDM---P 135

  Fly   960 VDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPE 1024
            |..:        |..||:..:..:..|..|:.||:|.|.|:|....|||..|||::||||::|.|
 Frog   136 VKKQ--------YADLLRMSSPCEKLIRRDIARTYPEHDFFKGQDSLGQEGLFNVMKAYSLVDRE 192

  Fly  1025 LGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            :|||||..||.|:||:...|..:|.:...||....:|..:.|.|.:..|.:|||..:::|.||:|
 Frog   193 VGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQLEYMLQDQLPEL 257

  Fly  1090 YVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK 1154
            ......:....::||:.|.||:|.:.|||....|:||:...|..:|||:..:|||:|::.:|:..
 Frog   258 SQHFRSHSFHTSMYASSWFLTLFLTTFPLPVATRIFDIFIYEGLEVIFRVGMALLTVNQTELMQL 322

  Fly  1155 DNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNV-----LQEEITTTNHHLE 1214
            | .|.:..:.:.|:|....:|.::::           |..|:|:||.     |::|....... |
 Frog   323 D-MEGMSQHFQKVIPHQFDSCPDKLI-----------LKAYQVKYNPKRMKRLEKEYAAIKSK-E 374

  Fly  1215 M-----LNREKTQNQHLEQQLQFAQSSIAQL-------ETTRSSQ-------QAQITTLQSQVQS 1260
            |     :.|.:|:|:.|:|:::..:...|.|       :.||:.:       :.::..::.|..:
 Frog   375 MEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRAQEAEENYAIKRELAVVKQQYYT 439

  Fly  1261 LELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFP 1325
            ...::|.....:.||.|...|..:..|:  :|....:|:..|.:...|
 Frog   440 ATESLQNAQSLIRQLQEKQMDPRITEEM--VLHLESELEHSRLRETET----------------- 485

  Fly  1326 LKVLEELTER---------------------DELGSPQKQKKEKTPFFEQLRQQQQQ 1361
            |..|:|:.::                     ||:   |..:|.:....:.:|:.|||
 Frog   486 LGALKEMQDKVVDLEKRNSALPDENNIALLHDEV---QALRKREAHALQAMREGQQQ 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	9/48 (19%)
		TBC	933..1152	CDD:214540	79/218 (36%)
		COG4372	<1190..>1353	CDD:443500	36/207 (17%)
evi5l	XP_031753513.1	TBC	112..320	CDD:214540	79/218 (36%)
		Smc	<358..>694	CDD:440809	35/205 (17%)