DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab23 and RAB5A

DIOPT Version :9

Sequence 1:	NP_649574.1	Gene:	Rab23 / 40701	FlyBaseID:	FBgn0037364	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_004153.2	Gene:	RAB5A / 5868	HGNCID:	9783	Length:	215	Species:	Homo sapiens

Alignment Length:	161	Identity:	55/161 - (34%)
Similarity:	93/161 - (57%)	Gaps:	5/161 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KVVIVGNGGVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIEIDGEDVRIMLWDTAGQEEFDCIT 103
            |:|::|...|||||::.|:.||.|.:..:.|||..||.:.:.:|...|:..:|||||||.:..:.
Human    22 KLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLA 86

  Fly   104 KAYYRGAQASVLVFSTTDRASFDAIKDWKRKVENECNEIPTVIVQ---NKIDLIEQAVVTADEVE 165
            ..|||||||:::|:..|:..||...|:|.::::.:.:  |.:::.   ||.||..:..|...|.:
Human    87 PMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQAS--PNIVIALSGNKADLANKRAVDFQEAQ 149

  Fly   166 TLAKLLNCRLIRTSVKEDINVASVFRYLATK 196
            :.|...:...:.||.|..:||..:|..:|.|
Human   150 SYADDNSLLFMETSAKTSMNVNEIFMAIAKK 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab23	NP_649574.1	Ras	50..199	CDD:278499	50/150 (33%)
Rab23	NP_649574.1	Rab23_like	50..197	CDD:133306	50/150 (33%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	55/161 (34%)
		Effector region. /evidence=ECO:0000255	49..57		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..215		55/161 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010