Protein Alignment Atg17 and epg-7

DIOPT Version :9

• Sequence 1: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Sequence 2: NP_509241.2
• Gene: epg-7 / 180996
• WormBaseID: WBGene00020334
• Length: 1338
• Species: Caenorhabditis elegans
• Alignment Length: 1452
• Identity: 280/1452 - (19%)
• Similarity: 498/1452 - (34%)
• Gaps: 504/1452 - (34%)

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSA- 64
            :|.::|::|.|:.:.||:|........|::.:.|......:::..|...|.....:..::..|.
 Worm     2 IMYHIFYMDRGQAMVFDLNAETTTFNVLQDMVSKEVGHRISDLTFLDESGTTPDGNKSLAEISTL 66

  Fly    65 GTDTNPIYMFL-TGDERLPPTIYNSDADNELRRQVEES---------HRLPPALETVRQRAQLAQ 119
            ||:|:|:|.|| :|:||   ..:|......:.:.::::         ::.|  |:...:..:.|:
 Worm    67 GTETSPVYFFLKSGNER---ENHNGSDVTYIFQMIDDAVDQAQYVLKNQDP--LKIYMELPERAK 126

  Fly   120 HMRELARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLEL 184
            :.|::..:....|.|||.:.....:||.|::.|::...::...|.:.|.....:..:..|....|
 Worm   127 NCRKVCAETLQMCARLVQQHRFLHKGWLALINNLDISVSKMDKRGKKFKLVHSKSEELIEKSDTL 191

  Fly   185 LRNFPDDLKQLGRIPILPDLMSLAEADFHGFDELLDNDDVFTAQQQPTPQQQALTESSQADSPNK 249
            |.|:.|.::||.||.:                    ..::|.   :|.   ..:|.:|...:|::
 Worm   192 LLNYSDVVEQLRRIEV--------------------PSEIFV---KPA---SLMTSTSTPINPDE 230

  Fly   250 KLKMGDEVETESGEQTERGVQTLTSSSSLARRPNLNLLQWISSKGNHRALQLMSDECIQGLDVFS 314
            |..:.|.:.....|.:..|:..|.                     |.:..||....        :
 Worm   231 KCTLFDFIAMADPEASLDGLPDLV---------------------NEKIRQLKEQN--------A 266

  Fly   315 VEIYEKLKEEVNQIIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQEQKEQALALQQNEARAQ 379
            :.:|.:| :.|::..|  || :.::.||:..|..:||   |.:|. .:|:|.....|........
 Worm   267 ISVYTRL-QSVHETSK--NQ-EYRDFKGINKRFSQLE---FSLKS-CEERKNLVHKLVAQILETP 323

  Fly   380 NLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLHTRLRRIVWIENGMSEFD 444
            .:.|.:.||.:...||..:..:.:|..:.|...|....||.|:..||.||:...| ::|    :|
 Worm   324 KINDQNKLPPIIEEHRQCMLTIFENFSEFRNMVRVFDQSKQEILKNLRTRMSGFV-VQN----YD 383

  Fly   445 N-RLLFN----HRCLRRAER-HICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFRQWATRLSADFD 503
            . |::.|    :.....|.| |:.:|.||..||..|..:|:|:|||::...|..:|.|..|....
 Worm   384 RLRVVLNDIVQYEYKSNAVRIHMDLIGQIRDAPILYSQSVSEIVRRRLLKTELEEWHTDHSTKCA 448

  Fly   504 RIHSEELSRRRDFNASFEGHFLNILFPGMGDMPPAFANEHPL-SFDTRLPSLSRSDMELLSSQLP 567
            :..::|...|.......:.|||:.||||:.|..|.|..:.|| .:||.||::::..::.|...||
 Worm   449 QFSTDEEKSREQLGRKLKKHFLHALFPGLFDNLPEFYVKAPLEKYDTDLPNIAKEYIKDLRDALP 513

  Fly   568 EL-----------------AGQLQLP------------------------------------DMK 579
            ||                 .|..|.|                                    |..
 Worm   514 ELEPFLKVTLPNVASKLATKGSKQHPSFGQTRVESFLTDEPMRMARSHFNYSPAAWLSEDGGDSS 578

  Fly   580 PVIDFFALRSDKNVEPDQEQERDIPLMAPRLAELQ------------------------------ 614
            ||......||.:|. ..:.|.|.||.: |.|.:|:
 Worm   579 PVPQPLMCRSPENA-LRESQCRSIPYV-PSLQQLEGLDGPAPGSSAPISIPNSTSSRINFKQSGR 641

  Fly   615 ----------AQAAASDC-----ETDTETEFEKLSTTSKCVAT----------SISTSL-VEQVA 653
                      ..|.:||.     ||..:.|...|.|.:|....          ||.:.| |.:..
 Worm   642 QQSSQDLHHVGSAVSSDTSLLGHETPVKMEDTVLMTENKSELNLESNMNDSNDSIDSLLDVYEHI 706

  Fly   654 QSTATEDLLMLSAGTLTEENA-GSFEKMRSDMESMT----KLAR--------------------- 692
            ..:|.:.||.||..|:..|:| ....||::.:.:||    ||.:
 Worm   707 DYSAEDILLGLSDHTVQLEDAVKRLSKMQNIVANMTPRNEKLFKYLHQTAPRDFEIIIHDGDKLK 771

  Fly   693 ----------------------------ACLAEARSNVGVFRSDVANYQDE----LQSELHLLRD 725
                                        |.|||...:   .:.::.|.|.|    :..|..|:.|
 Worm   772 NRVKELGESVESLETELENKKSTESNLEAKLAEMTVS---HKKEIENTQAECIKRMSVEFELMTD 833

  Fly   726 KCNVLKMMCEEREQKLQEK---LDEMSLKLQ--------------LAEQEKQAAVAQAREQLIHE 773
            .      |..:.:::::.|   ::|:..||:              .:|:.|:...|:.|.:|..|
 Worm   834 S------MSRQSKEQIESKDREIEELKAKLEKQNIAHEKALRNDPYSEEYKRTLTAEIRAELEKE 892

  Fly   774 HKTELE-------------------SLRCRFKLMTSMERSPS---------DSSLEKIERPTSSA 810
            .|..:|                   :|....::::|...|.|         ...||.:.|.....
 Worm   893 FKQRIEVITKAVECKKDEAFARQEKTLEIENRVLSSENESKSKKLEAMNREKEQLESLIRQMPEG 957

  Fly   811 SVV------------------------------------SANAGVDIDHLL-AQQRQELLAQRE- 837
            .|:                                    ..|..:.||::| ..:.|:|:.:||
 Worm   958 EVILDEFNALKESQPSAQIKDRFAAIRSRMERSTDGKCLDTNKVLLIDNILKVHKLQQLVNEREQ 1022

  Fly   838 -RAISEA-------------------VDSE----------------------------RSLWQSR 854
             |.:.::                   ||.|                            .::|...
 Worm  1023 YRDVIKSQPGGDQVLQFLENSTPTVPVDMEAYFNELTNFSGSFDEAGRKIAKIHEIAMETIWLQA 1087

  Fly   855 LLPLNSESVMANVG--ILKDMLADKERQ------------------LDQLREQNKILTQETYQLK 899
            |       |.||:|  .|:|:.||..::                  :|..|::.|.||: |.|:
 Worm  1088 L-------VRANLGGPSLRDISADIHKESYQKDVETVTSIAMMDIFIDHDRDEIKKLTR-TLQI- 1143

  Fly   900 TRLEMITNEDGNSWLKEKID-------YLNKDKCRLEEELSQEKSRRQEMESSVAAMRSSAYDLN 957
                         ||...:.       |..:|..::.|..|:.||...:: |:...|..|.|.
 Worm  1144 -------------WLNTNVSSLRSGGTYAIEDSPKIRECASKYKSMALKV-STYQGMEESFYQ-- 1192

  Fly   958 VGGPLTRSKSGVSSSHRSIALE-----------------------------GCARGDLVFVVWSM 993
               |:..|...|::|...:.:|                             |||    |.|:|..
 Worm  1193 ---PMAASTIQVATSPSELEVERSSQNTICTQTRLCLPAMNLLVSVQDIKIGCA----VIVIWHQ 1250

  Fly   994 RHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYC 1058
            .|..:::...|...|||...|:..|.:....:.|..                .:.|.||:..:.|
 Worm  1251 AHNAYVIFCSSPNRYFVKESSIRRLGINTQNAATRR----------------NWIIARVVRSDSC 1299

  Fly  1059 QARKDDNRYRVSRGSKFYRIKL 1080
            ..:|..|||.:..|:...|:::
 Worm  1300 SIKKPVNRYNLPIGTIVRRVEV 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	ATG11	943..1082	CDD:287363	33/167 (20%)
epg-7	NP_509241.2	Ubiquitin_like_fold	3..78	CDD:391949	18/74 (24%)
		SMC_prok_A	<753..>953	CDD:274009	29/208 (14%)
		ATG11	<1233..1322	CDD:371015	24/109 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I2758
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56800at33208
OrthoFinder	1	1.000	-	-		FOG0007474
OrthoInspector	1	1.000	-	-		oto18085
orthoMCL	1	0.900	-	-		OOG6_107790
Panther	1	1.100	-	-	LDO	PTHR13222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5138
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790