DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg17 and rb1cc1

DIOPT Version :9

Sequence 1:	NP_649573.2	Gene:	Atg17 / 40700	FlyBaseID:	FBgn0037363	Length:	1357	Species:	Drosophila melanogaster
Sequence 2:	XP_009300473.1	Gene:	rb1cc1 / 100332174	ZFINID:	ZDB-GENE-130206-1	Length:	1622	Species:	Danio rerio

Alignment Length:	1664	Identity:	384/1664 - (23%)
Similarity:	589/1664 - (35%)	Gaps:	629/1664 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65
            |.||||.|:.|..|:||..:|:|.|..||..||..:.|...:.||:|:|||.:....:|..||||
Zfish     1 MKLYVFQVNNGSTLTFDTELAVQTVLDLKHAIQAKYKIAIQHQVLVVNGGECMVAERRVCSYSAG 65

  Fly    66 TDTNPIYMF----LTGDE--RLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMREL 124
            ||||||::|    :..|.  .:|.|.:.  .:||:..:||||..:|....||..|.|||..|.|:
Zfish    66 TDTNPIFLFNKEMILCDRAPTIPKTTFT--IENEMELKVEESLMMPAVFHTVASRTQLALEMFEV 128

  Fly   125 ARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFP 189
            |:|....||||||::|||.|||:|::||::|.|..:......|.:.:..:.|..|.....|....
Zfish   129 AKKLCSFCERLVHDEHLQHQGWAAIMANLDDCTLSYQKLLLKFDTAYTNYQQDFEDIKLKLTKLG 193

  Fly   190 DDLKQLGRIPILPDLMSLAEADFHGFDELL------------DNDDV------------------ 224
            ..:..:.:||:|..|..      |.:.|.|            ::||:
Zfish   194 IAVSVMAKIPLLECLTR------HSYRESLEKSSSPRPRIIDEDDDIEDEEIAEASTRSPALCPP 252

  Fly   225 --FTAQQQPTPQQQALTESSQA-DSPNKKLKMGDEVETESGEQTERGVQTLTSSSSLARRPNLNL 286
              ...|:.|:|    ::.|||| .||..:||....:: |:.::.|...:.:...|.     |:.|
Zfish   253 DNLKNQKSPSP----VSASSQASSSPQDRLKSSSSLK-EALQEEEESPERMAMPSF-----NVTL 307

  Fly   287 LQWISSKGNHRALQLMSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKL 350
            |.||:.:.....::.:..:|...::.....|.:....|..: |.||.|| ::|.||||.|||..|
Zfish   308 LDWINVQDRPNDVESVVRKCFDSINRLDPRIIQPFLTECRETITKLDNQ-NMKAIKGLEDRLYAL 371

  Fly   351 EEFKFRIKKMVQEQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCI 415
            ::.....||:|.||||.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:..
Zfish   372 DQMIASCKKLVNEQKELAQGFLANQKRAENLKDTSVLPDLCLSHANQLMIMLTNHRKLLDIKQKC 436

  Fly   416 ANSKDELGWNLHTRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAE 480
            ..:|.||..||..||:...::.....:...:|....|.|......:.::|.:...|..|..||.|
Zfish   437 TTAKQELANNLQVRLKWCCYVMLHADQDGEKLQALLRLLTELLERVRVVEALSTVPQMYCLAVVE 501

  Fly   481 VVRRKIFSDEFRQWATRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPP-AFANEH 543
            |||||:|...:||||..|..|...::..|..:|..|...|...|| |.||.|:...|| :|....
Zfish   502 VVRRKMFIGHYRQWANALVKDGKNLYEAEKVKRETFGKLFRKSFLRNRLFRGLDSWPPSSFCTRK 566

  Fly   544 PLSFDTRLPSLSRSDMELLSSQLP-ELAGQLQLP---DMKPV----------------IDFFA-- 586
            |..||..||.:|.||::.|.|..| |:...|::|   |.:|:                :|..:
Zfish   567 PRRFDFELPDISLSDLQYLKSCCPSEVQPYLRVPTLCDFEPLNQHVEVLHQLVQAAQSVDEMSQT 631

  Fly   587 ----LRSDKNVEPDQEQERDIPLMAPR--------------LAELQAQAAASDCE---------- 623
                |...|| ...|..:|...| .||              |:.|..:  |.||:
Zfish   632 ITDLLNEQKN-SYSQSAQRSTAL-TPRSESAIEITSTSTKTLSTLSLK--APDCQPLALPGPLED 692

  Fly   624 -----TDTET-EFEKLS------------------------------------------------ 634
                 .|.:| :||.:.
Zfish   693 LSPDSIDAQTFDFETIGHPSMDPVLQQGSLDLDSLAESPESDFMSAVNEFVIEENLLSPNPISDP 757

  Fly   635 TTSKCVATSISTSLVEQV----AQSTATED-------LLMLSAG---TLTEENAGSFEKMRSDME 685
            |:.:.:..|:.:|::..:    .|.|.|.:       .:.|||.   :..||:..:..|::.|:.
Zfish   758 TSPEMMVESLYSSVINAIDSKRIQDTTTLEKENSKIAAIKLSADRYRSAAEESQNNLRKVKEDLY 822

  Fly   686 SMTKLARACLAEAR-----------------SNVGVFRSD--------------------VANYQ 713
            ....|.   |.|.|                 |||.....:                    :....
Zfish   823 HFRGLV---LKEQRDFGFALKTMTTEVHNALSNVSYSHEEELKETQQTHLQSLKEDHEKQIRTLT 884

  Fly   714 DELQSELHLLRDKCNVLKMMCE-----------------ERE--------------QKLQEKL-- 745
            :||:....:::|   |.:.|.|                 |||              |.|:||:
Zfish   885 EELEGNQKIVKD---VQRAMLELEGLVERKEKEIYQLESERERSTQELQDLHKQAVQNLEEKILK 946

  Fly   746 ------------DEMS-------------------------------LKLQLAEQ---------- 757
                        ||::                               |:.:|.:|
Zfish   947 QSEELKSALLSKDELAGQLEKLHFEIEHGQQKIRQEMKNAEKVHLQELETRLNQQHEAELQTFRL 1011

  Fly   758 EKQAAVAQARE-------QLIHEHK-----------------TELESLRCRFKL-MTSMERSPSD 797
            ||::|:.:..:       .|:..|.                 |||...||:.:: |...|....|
Zfish  1012 EKESALDKLVQDNLVKLRDLMDSHSAELKERDGRSKDMDARITELADARCKLEVEMALKEAEMED 1076

  Fly   798 SSLEKIERPTSSASVVSANAG-------VDIDHL--------------LAQQRQELLAQRERAIS 841
            ..|:..|..::...|:.|...       :.||.|              ||:.|..:..:::..||
Zfish  1077 MRLQYEEAKSTQEEVLKAEFATQTSTLKMQIDTLSLQLHQKNEEYEVGLAELRALMRLEKDHCIS 1141

  Fly   842 EAVD------------------------------------------------------------- 845
            |.||
Zfish  1142 ELVDRHEEESTLLRHEFSALKQKSQDVEKDCEERVLKIERDYKDRVDALQREKVEEQRAFQEKED 1206

  Fly   846 ----------SERSLWQSR--------LLPLNSESVMANVGILKDMLAD---------------- 876
                      :|.||...|        ||.:..|...|....|::.|.|
Zfish  1207 DLRTVIGDLQAENSLLSGRLEQERVEALLRVQEEKEEAVKAALQEALRDIQLQKEETETRLLGQI 1271

  Fly   877 -------KERQ-----------------------LD---------------QLREQNKILTQETY 896
                   |:||                       ||               :|.|:.|  .:|..
Zfish  1272 ELLEKQLKDRQSTDTVASSAEQTEAGVQAETAVSLDSGQWTEERASLLAKLELLERTK--NEEMQ 1334

  Fly   897 QLKTRL--------------EMITNEDGNSWLKEK--------------IDYLNKD-------KC 926
            .|||.|              |.:..|...|.|.||              |:.|::|       |.
Zfish  1335 NLKTSLIAEQQTNFNTVLTREKLKKEQIISDLTEKLKNVMQQQEKDKGLIETLSEDRASILQEKK 1399

  Fly   927 RLEEELSQEKSR--------------------------------------------------RQE 941
            :|||||::.:|.                                                  .:.
Zfish  1400 QLEEELNRLRSTVLVSSSFFPPNPIVPVVAEAHGACGPAQVDALSPSFPDPERLISMAAFRDEER 1464

  Fly   942 MESSVAAMRSSAYDLN---------------------------VGGPLTRSKSGVSSSH-RSIAL 978
            :||:|.|...:.:..|                           ....:::|.|.|||.| ..||:
Zfish  1465 VESAVEASMMTVHSDNSMLSEEKQRILILERTLHMKEEENKRLSQRLMSQSMSSVSSRHSEKIAI 1529

  Fly   979 EGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQLTAPTSPTPSLDPSQTVVDINQIP 1043
            .....||||.::...||..:::.....||||:|::||.:|.|...|..|             :.|
Zfish  1530 RDFQVGDLVLIILDERHDNYVLFTVGPTLYFLHSESLTALDLKPATGAT-------------RRP 1581

  Fly  1044 LPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIKLAP 1082
               :.:|:|::||||||:|..||::|..|:||||:|..|
Zfish  1582 ---WVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVP 1617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg17	NP_649573.2	ATG11	943..1082	CDD:287363	49/166 (30%)
rb1cc1	XP_009300473.1	UBQ	3..77	CDD:294102	35/73 (48%)
		iSH2_PI3K_IA_R	897..1050	CDD:304922	20/152 (13%)
		FAM76	<1101..1193	CDD:292665	11/91 (12%)
		FAM184	1113..1278	CDD:292293	19/164 (12%)
		DUF342	<1294..1415	CDD:302792	26/122 (21%)
		ATG11	<1525..1617	CDD:287363	38/107 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587104
Domainoid	1	1.000	293	1.000	Domainoid score	I1481
eggNOG	1	0.900	-	-		E1_KOG4572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56800at33208
OrthoFinder	1	1.000	-	-		FOG0007474
OrthoInspector	1	1.000	-	-		oto38820
orthoMCL	1	0.900	-	-		OOG6_107790
Panther	1	1.100	-	-	LDO	PTHR13222
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5138
SonicParanoid	1	1.000	-	-		X6346
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790