DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xe7 and AKAP17A

DIOPT Version :9

Sequence 1:	NP_730984.1	Gene:	Xe7 / 40699	FlyBaseID:	FBgn0010772	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_005079.2	Gene:	AKAP17A / 8227	HGNCID:	18783	Length:	695	Species:	Homo sapiens

Alignment Length:	763	Identity:	260/763 - (34%)
Similarity:	393/763 - (51%)	Gaps:	151/763 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IENVADCIPFYLPHSLYLKPLAKMQISVSLPTIKS-GKSVSNLEIMDKLGAELKPDKFLLLKVSK 70
            :.:.::.:.....:.|||||:.||.|||:||.:|. |||:||.|:|::|...::..:|..|::||
Human     7 VHDTSEAVELCPAYGLYLKPITKMTISVALPQLKQPGKSISNWEVMERLKGMVQNHQFSTLRISK 71

  Fly    71 STVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDARN 135
            ||::.||.|.|::.:..:::.:..|||.::::||||:..:||.||.|.||||||||||:||||::
Human    72 STMDFIRFEGEVENKSLVKSFLACLDGKTIKLSGFSDILKVRAAEFKIDFPTRHDWDSFFRDAKD 136

  Fly   136 MDEMKAGERPDTIHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKS 200
            |:|...||||||||:..||.:||..:.|..|   ||||::..::|||||.:|.||||:.||||:.
Human   137 MNETLPGERPDTIHLEGLPCKWFALKESGSE---KPSEDVLVKVFEKFGEIRNVDIPMLDPYREE 198

  Fly   201 MQADINGMRTFSFEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLVRKFVD-KTQAINICVSFDKQK 264
            |..  ....||||...:.||.|||:.||..|::||...||.||:.|..| |..|.||.||||..|
Human   199 MTG--RNFHTFSFGGHLNFEAYVQYREYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTK 261

  Fly   265 HLSDSNIQRRERIRKKF-----------IAKAKAEDEEREKLKKQQE-EELDRERQKQEELKKAE 317
            ||||::|::|:..|:|.           ..:.:||:.:|.:.:||:| |||:|||:::|:|:|.|
Human   262 HLSDASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKRE 326

  Fly   318 AEKQREREERRKEKHMKKIQERGQVEISQKIRIEERKLMIAQRKLESIRTLEKLFER---IQLKQ 379
             :|||:||.||.:|.::|:|...|.::.:||::|||||::|||.|:|||.:.:|..|   ::|::
Human   327 -QKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLRE 390

  Fly   380 R----DKNRRVKQDDDKDIQRGRL--VEKYKAATEKLVCDQRKIVQEIKSNTPLLGLLKSKSKKS 438
            :    :|.|..:|::.:.:|...|  ||:.|   |:.:..||| .:|::..  ||.:|.||.
Human   391 QEQKEEKLRLQQQEERRRLQEAELRRVEEEK---ERALGLQRK-ERELRER--LLSILLSKK--- 446

  Fly   439 AVPVDASSEDE-----------------------AAASKRHKMGNGVTESAP------------P 468
              |.|:.:.||                       .:|:..|.:|......||            |
Human   447 --PDDSHTHDELGVAHADLLQPVLDILQTVSSGCVSATTLHPLGGQPPAGAPKESPAHPEADGAP 509

  Fly   469 GDVNSAL---NPLNAVAAMAAGAVPG--------PGGYSAKVASEWMQSLSMFGYGLPGVFTGAL 522
            ..||.::   .|...|.: :...||.        |||..:.:.....|.     .|:|.......
Human   510 KSVNGSVAEEAPCKEVQS-SCRVVPEDGSPEKRCPGGVLSCIPDNNQQP-----KGIPACEQNVS 568

  Fly   523 YRPPAPFPVSSNYRGFAPRPRGRGRGRGIGIRGSRSGYDTYYNTKHDRYDDENENGYYHRSSRGR 587
            .:.........|      |...:||||..|                        :|...|..|.|
Human   569 RKDTRSEQDKCN------REPSKGRGRATG------------------------DGLADRHKRER 603

  Fly   588 NRSRSSSSYSRSRSRSRGRRIVCRSRRSKSRSRSHYRKSSYSSRSRRSHSRSSRSRSKTPSQRKN 652
            :|:|.:||....|.|               :.|..::|.:|.       ..|.|.||.:|...::
Human   604 SRARRASSREDGRPR---------------KERRPHKKHAYK-------DDSPRRRSTSPDHTRS 646

  Fly   653 RKLASTRRSRSSSYSRSRSRSHSRRQSSSRRDHRGRHRSSRSNSRSRS 700
            |:..|..|.|       |.||..||.|:||:..|.|.||.||.|||.|
Human   647 RRSHSKDRHR-------RERSRERRGSASRKHSRHRRRSERSRSRSPS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xe7	NP_730984.1	RRM_AKAP17A	142..268	CDD:240710	64/126 (51%)
		GBP_C	<275..387	CDD:303769	48/130 (37%)
		coiled coil	356..367	CDD:293879	6/10 (60%)
		coiled coil	376..387	CDD:293879	3/14 (21%)
AKAP17A	NP_005079.2	PKA-RI and PKA-RII subunit binding domain	83..112		7/28 (25%)
		RRM_AKAP17A	143..265	CDD:240710	64/126 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..337		22/58 (38%)
		GBP_C	<345..433	CDD:303769	31/91 (34%)
		coiled coil	424..433	CDD:293879	3/9 (33%)
		PKA-RI-alpha subunit binding domain	425..454		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..695		64/271 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148102
Domainoid	1	1.000	361	1.000	Domainoid score	I959
eggNOG	1	0.900	-	-		E1_KOG2891
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2198
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004994
OrthoInspector	1	1.000	-	-		oto91715
orthoMCL	1	0.900	-	-		OOG6_107556
Panther	1	1.100	-	-	LDO	PTHR12484
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4206
SonicParanoid	1	1.000	-	-		X4065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780