DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xe7 and Akap17b

DIOPT Version :9

Sequence 1:	NP_730984.1	Gene:	Xe7 / 40699	FlyBaseID:	FBgn0010772	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_002730229.1	Gene:	Akap17b / 313434	RGDID:	1566363	Length:	942	Species:	Rattus norvegicus

Alignment Length:	830	Identity:	219/830 - (26%)
Similarity:	365/830 - (43%)	Gaps:	165/830 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LYLKPLAKMQISVSLP-TIKSGKSVSNLEIMDKLGAELKPDKFLLLKVSKSTVNTIRLEAELDER 85
            |||||:||:.|:|.|| .|:..:..||.|::|:|.:.:.||:|..:::||||.:.||.|.|.:.|
  Rat    21 LYLKPIAKLMINVLLPECIEPVRPFSNWEVLDQLKSLICPDQFTTVRLSKSTKDFIRFEGEAETR 85

  Fly    86 KRLRAAIQRLDGISLRISGFSESFRVRCAESK---DDFPTRHDWDSYFRDARNMDEMKAGERPDT 147
            ..::....:|.|..::::|.....:|...:::   :.||...: .|....|...|..|:   ||:
  Rat    86 SLVQILKAKLHGKIIKLNGLKTDLKVVATDAQGEWEHFPKEKE-ASVIEGAEEQDHDKS---PDS 146

  Fly   148 IHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKSMQADINGMRTFS 212
            |:...||.:||.|:.|..|   ||.|.|.:.:||.||:::.||||:.||||:.|.....|...|.
  Rat   147 IYFEGLPCKWFAPKGSSGE---KPCEEILRVVFESFGKIKNVDIPMLDPYREVMTGGSFGGFNFG 208

  Fly   213 FEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLVRKFVD-KTQAINICVSFDKQKHLSDSNIQRRER 276
            .:   .||.::|::|.:.|::||:..||.||:.|..| |..|.||.|.||..||.|:..||||.:
  Rat   209 LQ---TFEAFIQYQESTDFIKAMESLRGMKLMLKGDDGKALACNIKVMFDTTKHFSEGAIQRRNQ 270

  Fly   277 IRKKFIAKAKAEDEEREKLKKQQEEELDRE-----RQKQEELKKA----EAEKQREREERRKEKH 332
            .|    .|.:..:|||:|.||::||..:|:     |:.||:.|||    .|.|:|:|..:|:||.
  Rat   271 ER----LKLQELEEERKKEKKREEEVAERKRKDEVRKAQEKRKKARDRRRALKERDRHRQRREKV 331

  Fly   333 MKKIQERGQVEISQKIRIEERKLMIAQRKLESIRTLEKLFERIQL-KQRDKNRRVKQ-------- 388
            ..|.:.|.:.|.|.:  .||||.::|:|::|::|.|..|.::|.: .:::||....|
  Rat   332 KAKSEARQEQESSGE--WEERKYLLARRRVEALRLLRVLLKKIAVWMRKEKNLEPCQTHISLLLN 394

  Fly   389 ---------------DDDKDIQRGRLV---EKYKAATEKLVCDQRKIV--QEIKSNTPLLGLLKS 433
                           :.|.....|..|   |:.::.|:.|: ||:::.  |..||:    |..|.
  Rat   395 CLGSTQCNPQEVDTMESDAHHTPGTTVKSPEEEESNTQHLL-DQKEMPRHQIPKSD----GKQKQ 454

  Fly   434 KSKK-SAVPVDASSEDEAA-----ASKRHKMGNGVTES------APPGDVNSALNP--------- 477
            |.|| :...:..||....|     ::::.:.|.|:|:.      :....:.|.:.|
  Rat   455 KVKKRTKTQLQKSSHSPGAKQIRYSARKEETGKGLTDGCDYSLVSDQDSLQSTVTPDQSLEKEDQ 519

  Fly   478 LNAVAAMAAGAVPGPGGYSAKV--ASEWMQSLSMFGYGLPGVFTGALYRPPAPFPVSSNYRGFAP 540
            .:|..:.::..|....|...|:  ..|::..|..: |..|......|.....|.........:|
  Rat   520 CSANESHSSRQVVRNRGRKQKIYETDEFIDYLLNY-YQTPEYARFCLEASHLPSTCQWQRDVYA- 582

  Fly   541 RPRGRGRGRGIGIRGSRSGYDTYYNTK--HDRYDDENENGY---YHRSSRGRNRSRSSSSYSRSR 600
                :|.|..|.:|..||..|:....:  .::..|| |.|:   |.:......:.....:|::..
  Rat   583 ----KGDGFQIYLRKQRSHSDSLSEVESLQEKELDE-EQGWPEMYMKGPESTPQKTGKMNYAKEF 642

  Fly   601 SRSRGRRIVCRSRRSKSRSRSHYRKSSYSSRSRRS------------HS---RSSRSRSKTPSQR 650
            ::               :.::||:..|..|....|            ||   |.|:...|:|:..
  Rat   643 TK---------------KLKNHYKDISSESDEHLSLPEGENYPVEKIHSHGVRDSQHTRKSPASS 692

  Fly   651 KNR-------------KLASTRR--SRSSSYSRSRSRSHSRRQSSSRRDHRGRHRSSRSNSRSRS 700
            ..|             :::|...  |.:.|.:....||.:...||..:...|..|..|...::||
  Rat   693 SLRSVDVGLPLADFLEEISSDSECFSETLSMNEEEERSVAVYNSSPEKRPLGTDRIGRGKQKTRS 757

  Fly   701 HTPKEVILEADKLVASAEKIQRTIDQHTKDRMREEEREIKEKFRHPRTNS 750
            .                   |:|:....|  ...||:..|.|.|.|...|
  Rat   758 S-------------------QQTLCSEWK--YDSEEKYSKHKVRAPGKRS 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xe7	NP_730984.1	RRM_AKAP17A	142..268	CDD:240710	51/126 (40%)
		GBP_C	<275..387	CDD:303769	41/121 (34%)
		coiled coil	356..367	CDD:293879	3/10 (30%)
		coiled coil	376..387	CDD:293879	2/11 (18%)
Akap17b	XP_002730229.1	RRM_AKAP17A	144..262	CDD:240710	51/123 (41%)
Akap17b	XP_002730229.1	Med31	<538..>565	CDD:295183	5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2891
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004994
OrthoInspector	1	1.000	-	-		otm46389
orthoMCL	1	0.900	-	-		OOG6_107556
Panther	1	1.100	-	-	O	PTHR12484
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700