DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xe7 and Akap17a

DIOPT Version :9

Sequence 1:	NP_730984.1	Gene:	Xe7 / 40699	FlyBaseID:	FBgn0010772	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001120718.2	Gene:	Akap17a / 288526	RGDID:	1564640	Length:	712	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	208/791 - (26%)
Similarity:	338/791 - (42%)	Gaps:	174/791 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTHIQTIENVADCIPFYLPHSLYLKPLAKMQISVSL----------------PTIKSGKSVSNLE 49
            |:....:.:.::.:|......|||||:|::.|||||                |.....::|||.|
  Rat     1 MSSATIVHDPSEAVPLCPALGLYLKPIARVTISVSLPPPPPAPPPSPSSTSPPPRAPSRAVSNWE 65

  Fly    50 IMDKLGAELKPDKFLL--LKVSKSTVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVR 112
            :|:.|.|..:..:..|  |::::.....:|.|.|::.|..:|.|:..|||.::.:||.....||.
  Rat    66 VMEGLRAMAQGARAPLSSLRLARGGPEVVRFEGEVENRALVRPALAGLDGKTMMLSGLPHGLRVS 130

  Fly   113 CAES----KDDFPTRHDWDSYFRDARNMDEMKAGERPDTIHISHLPMRWFCPRHSEHEENV---- 169
            .||:    .||....|                     ||||:..||.|||.||.....:..
  Rat   131 AAEATPPPTDDPAHPH---------------------DTIHLQGLPCRWFAPRGGSGGDEAGGIS 174

  Fly   170 ---------KPSENIFKRIFEKFGRVRMVDIPICDPY--RKSMQADINGMRTFSFEQDVLFEGYV 223
                     :|||.:.::.|..||.:|.||||:.|||  .........|.|       :.||.||
  Rat   175 SPGGIASAERPSEALLRQAFGAFGEIRHVDIPMLDPYLGEDGSHGGGGGGR-------LRFEAYV 232

  Fly   224 QFEEYSSFVRAMDEFRGNKLVRKFVD-KTQAINICVSFDKQKHLSDSNIQRRERIRKKF------ 281
            |:.|..::.|||...||.||:.:..| |..|..|.|:.|..:|||:::|:||:..|:|.
  Rat   233 QYRERDAYARAMAALRGAKLMFRGTDGKAVACGIKVTSDATQHLSEASIRRRQLERQKLQELEQR 297

  Fly   282 ---IAKAKAEDEEREKL--KKQQE-EELDRERQKQEELKKAEA-EKQREREERRKEKHMKKIQER 339
               ..:.:.|||.|.:.  :||:| |:..|.|:::|:|::.|| ::.|:|..||:|:..::.:..
  Rat   298 REEQKRKEREDEARRRAGQRKQREAEQQQRARRREEKLRRREARQRARKRRGRRREEEEEEEEAE 362

  Fly   340 GQVEISQKIR--IEERKLMIAQRKLESIRTLEKLFERI------QLKQRDKNRR------VKQDD 390
            .|..:.::..  .|.|:|::|||.|:|:|.:..|..|.      |.:|.::.||      :::..
  Rat   363 PQPVLGREEEEGAEPRRLLLAQRNLQSVRLIAALLARAEAARRRQREQSEERRRHAKEAELRRQQ 427

  Fly   391 DKDIQRGRLVEKYKAATEK---LVCDQRKIVQEIKSNTPLLGLLKSKSKKSAVPVDASSEDEAAA 452
            :.:::|.|..|..:...||   |...:|:  :|::..  ||.||.::.......|..:
  Rat   428 EAELRRQREAELRRVEEEKRRALGLQRRE--RELRHR--LLALLLARGPGLGCLVGGA------- 481

  Fly   453 SKRHKMGNGVTESAPPGDVNSALNPLNAVAAMAAGAVPGPGGYSAKVASEWMQSLSMFGYGLPGV 517
                  |.|       .||..|.|     :.||.|:..|..|     .|:.|....:.|.|...:
  Rat   482 ------GTG-------SDVLGAGN-----SKMAVGSGHGEAG-----QSQTMTGSEIRGDGRENM 523

  Fly   518 FTGALYRPPAPFPVSSNYRGFAPRPRGRGR-GRGIGIRGSRSG------YDTYYNTKHDRYDDEN 575
            .||:        .|:::..|...|...:.: |.||...|..:|      ..|..:.:....|.:.
  Rat   524 KTGS--------DVATSGNGHIDRENEKIKTGSGIPATGGGTGDPRGADKQTGSSVQPTGSDAKT 580

  Fly   576 ENGYYHRSSRGRNRSRSSSSYSRSRSRSRGRRIVCRSRRSKSRSRSHYRKSSYSSRSRRSHSRSS 640
            .|| ...:..|..|...:.::|.:.:...|          ...:.|...|.:..|.|..:.|.|:
  Rat   581 GNG-ARGTGGGPGRDPIAKTWSENMTTGSG----------SPETGSGVAKMATVSASNETESSSA 634

  Fly   641 RSRSKTPSQRKNRKLASTRRSRSSSYSR----SRSRSHSRRQSSSRRDH-----------RG-RH 689
            :.:: .||...:|:.... ..|.|.:||    |..:|.||..|..||.|           || ||
  Rat   635 KLKA-MPSSCSDRERCGL-EGRPSWHSRDFGGSSGQSRSREGSERRRPHEEEDGGGRDRKRGHRH 697

  Fly   690 RSSRSNSRSRS 700
            |..|..|||||
  Rat   698 REDRGRSRSRS 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xe7	NP_730984.1	RRM_AKAP17A	142..268	CDD:240710	48/141 (34%)
		GBP_C	<275..387	CDD:303769	37/138 (27%)
		coiled coil	356..367	CDD:293879	5/10 (50%)
		coiled coil	376..387	CDD:293879	4/16 (25%)
Akap17a	NP_001120718.2	RRM_SF	147..278	CDD:418427	48/137 (35%)
Akap17a	NP_001120718.2	DUF4670	<282..445	CDD:406200	42/162 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341970
Domainoid	1	1.000	172	1.000	Domainoid score	I3617
eggNOG	1	0.900	-	-		E1_KOG2891
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4003
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004994
OrthoInspector	1	1.000	-	-		otm46389
orthoMCL	1	0.900	-	-		OOG6_107556
Panther	1	1.100	-	-	LDO	PTHR12484
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750