DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xe7 and cux-7

DIOPT Version :9

Sequence 1:	NP_730984.1	Gene:	Xe7 / 40699	FlyBaseID:	FBgn0010772	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_498651.2	Gene:	cux-7 / 176066	WormBaseID:	WBGene00000854	Length:	495	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	160/464 - (34%)
Similarity:	263/464 - (56%)	Gaps:	39/464 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LYLKPLAKMQISVSLPTIK-SGKSVSNLEIMDKLGAELKPDKFLLLKVSKSTVNTIRLEAELDER 85
            |||||:|.::|:|.||.:. .|:|:||.::|::|...:.|.:....||.:|.::::..||||...
Worm    25 LYLKPMAVIKITVVLPRMTIPGQSISNWDLMERLKRAIDPIQMDSCKVRESNIDSVIFEAELLSL 89

  Fly    86 KRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDARNMDEMKAGERPDTIHI 150
            ..::..::.|||.|:::|||:|..:|:..|:|.|||:|||||.:|. ...|||||.||||||:::
Worm    90 GIMQKTMKILDGFSMKVSGFAEPLKVKTKEAKLDFPSRHDWDDWFM-KHKMDEMKPGERPDTVYL 153

  Fly   151 SHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYRKSMQADINGM--RTFSF 213
            :.:|::|||..:     |..|||...:...|.||.||:||||||||.|..|.:.|:|:  :.|..
Worm   154 ARIPVKWFCDGY-----NDLPSERRLRVAMEAFGSVRVVDIPICDPLRSRMNSKISGIQQKGFGL 213

  Fly   214 EQDVLFEGYVQFEEYSSFVRAMDEFRGNKLVRKFVDKTQAINICVSFDKQKHLSDSNIQRRERIR 278
            .|||.||.||||.||..|..|||..|..|..::...:....|:.|.||:.:|||:..|.:|...|
Worm   214 GQDVFFEAYVQFMEYKGFATAMDSLRNRKWAKRIDGRFFQANVKVDFDRSRHLSEVQIAKRAEER 278

  Fly   279 KKFIAKAKAEDEEREKLKKQQEEELDRERQKQEELKKAEAEKQREREERRKEKHMKKIQERGQVE 343
            ::.         |.|:| :|:||||:.:||::.::|:...:|.|.||:|.:::..|:..||...|
Worm   279 RQI---------ETERL-RQEEEELNIKRQEELKVKQELDDKDRRREDRERKRREKRELERMAEE 333

  Fly   344 ISQKIRIEERKLMIAQ-----RKLESIRTLEKLFERIQLKQRDKNRRVKQDDDKDIQRGRLVE-- 401
              :|.|:|:.:|...|     |:|:.:|.|:.|||:|:.::..:.|:.::....::.:.:.:|
Worm   334 --EKKRLEKERLEAEQRSRATRRLQGVRLLKFLFEKIEAREERRKRKEEEKLKDELSKIKELEEQ 396

  Fly   402 --KYKAATEKLVCDQRKIVQEIKSNTPLLGLLKSKSKKSAVPVDASSEDEAAASKRHKMGNGVTE 464
              :.:.|..:.:..||:|....:        ||.|.|.|....| ...|:...|:|.:.....|.
Worm   397 PVEQEDALRQALLQQREIRMRER--------LKEKMKASGAEKD-KKRDKNKTSRRRRTNRHDTS 452

  Fly   465 SAPPGDVNS 473
            |:...|.:|
Worm   453 SSSSEDSDS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xe7	NP_730984.1	RRM_AKAP17A	142..268	CDD:240710	55/127 (43%)
		GBP_C	<275..387	CDD:303769	35/116 (30%)
		coiled coil	356..367	CDD:293879	3/15 (20%)
		coiled coil	376..387	CDD:293879	1/10 (10%)
cux-7	NP_498651.2	RRM_AKAP17A	145..268	CDD:240710	55/127 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160053
Domainoid	1	1.000	260	1.000	Domainoid score	I1057
eggNOG	1	0.900	-	-		E1_KOG2891
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I1907
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004994
OrthoInspector	1	1.000	-	-		oto17355
orthoMCL	1	0.900	-	-		OOG6_107556
Panther	1	1.100	-	-	LDO	PTHR12484
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4206
SonicParanoid	1	1.000	-	-		X4065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820