DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xe7 and akap17a

DIOPT Version :9

Sequence 1:	NP_730984.1	Gene:	Xe7 / 40699	FlyBaseID:	FBgn0010772	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001128287.2	Gene:	akap17a / 100038187	XenbaseID:	XB-GENE-486903	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	737	Identity:	233/737 - (31%)
Similarity:	373/737 - (50%)	Gaps:	134/737 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QTIENVADCIPFYLPHSLYLKPLAKMQISVSLPTIKS-GKSVSNLEIMDKLGAELKPDKFLLLKV 68
            :.:|....|       .|||||:.||.|||:||.:|. |||:||.|:|::|...:...:|..|::
Frog    12 EAVELCGSC-------GLYLKPITKMIISVALPQLKQPGKSISNWEVMERLKGMVNNHQFSTLRI 69

  Fly    69 SKSTVNTIRLEAELDERKRLRAAIQRLDGISLRISGFSESFRVRCAESKDDFPTRHDWDSYFRDA 133
            ||||::.||.|.|::.:..::..:..|||.|:::||||:..:||..|.|.||||||||||:||||
Frog    70 SKSTMDFIRFEGEVENKSLVKTFLAALDGKSIKLSGFSDILKVRAVEYKLDFPTRHDWDSFFRDA 134

  Fly   134 RNMDEMKAGERPDTIHISHLPMRWFCPRHSEHEENVKPSENIFKRIFEKFGRVRMVDIPICDPYR 198
            ::|:|...||||||||:..||.:||..:.|..|   ||:|::..::|..||.:||||||:.||||
Frog   135 KDMNESLPGERPDTIHLEGLPCKWFALKDSGSE---KPNEDVLIKVFNLFGEIRMVDIPMLDPYR 196

  Fly   199 KSMQADINGMRTFSFEQDVLFEGYVQFEEYSSFVRAMDEFRGNKLVRKFVD-KTQAINICVSFDK 262
            :.|..  ....||||...:.||.|||::||..||:||:..||.||:.|..| |..|.||.||||.
Frog   197 EEMTG--RSFHTFSFGGHLNFEAYVQYKEYVGFVKAMNALRGMKLMYKGEDGKAVACNIKVSFDS 259

  Fly   263 QKHLSDSNI--------------QRRERIRKKFIAKAKAEDEEREKLKKQQE-EELDRERQKQEE 312
            .||||:::|              ||||..::|   :.:||:.::|:.:||:| ||:::||::.|:
Frog   260 TKHLSEASIKKRQLERQKLQELEQRREEQKRK---EKEAEERQKEEERKQKELEEVEKERKRIEK 321

  Fly   313 LKKAEAEKQREREERRKEKHMKKIQERGQVEISQKIRIEERKLMIAQRKLESIRTLEKLFERIQL 377
            :::.| |||:|||.||.:|.::|||...|.::.:|||.|||:|::|||.|:|||.:.:|..::
Frog   322 IRRKE-EKQKEREARRNKKKLQKIQAEEQKKLQEKIRFEERRLLLAQRNLQSIRIIAELLSQV-- 383

  Fly   378 KQRDKNRRVKQDDDKDIQRGRLVEKYKAATEKLVCDQRKIVQEIKSNTPLLGL------LKSKSK 436
                |..::.:.::.:.:|.||::..:...|:..  :.|.|:|.|...  |||      |:.|..
Frog   384 ----KATKLNEQEEMEAERLRLLQLEERRKEQEA--ELKRVEEEKQRA--LGLQRKERELREKLV 440

  Fly   437 KS----AVPVDASSEDEAA----------ASKRHKMGNGVTESA---PPGDVNSALNPLNAVAAM 484
            ||    ::..|...:|:.:          .....:..|.||.::   |.|:....|:.|.|.:..
Frog   441 KSFLNRSMCSDHQKQDQCSPVLCFPLKPNEDTHQEPRNYVTSTSTQTPSGNEPLKLHSLYANSTT 505

  Fly   485 AAGAVPGPGGYSAKVASEWMQSLSMFGYG--LPGVFTGALYRPPAPFPVSSNYRGFAPRPRGRGR 547
            ..|           |..| |.:|..:...  :||             .|.|.:
Frog   506 KNG-----------VCCE-MSALQEYKQASVIPG-------------HVMSLH------------ 533

  Fly   548 GRGIGIRGSRSGYDTYYNTKHDRYDDENENGYYHRSSRGRNRSRSSSSYSRSRSRSRGRRIVCRS 612
                .|.|:.:.::|..|.::....:..    .|::...:......:.....::..:.|:...:.
Frog   534 ----SILGNSAQHNTSVNVQNCSLKESE----VHKNGTEQEEKEQQTFEIHCQTEDKARKHKSKH 590

  Fly   613 RRSKSRSRSHYRKSSYSSRSRRSHSRSSRSRSKTPSQRKNRKLASTRRSRSSSYSRSRSRSHSRR 677
            :|..|......:|...|:::..|..||.|.:|                |.|..:|:     |..:
Frog   591 KRDVSSDVDGRKKVKKSNKTHFSGDRSPRQQS----------------SGSPKFSK-----HKSK 634

  Fly   678 QSSSRRDHRGRHRSSRSNSRSR 699
            ....|.||:.:....||.||.|
Frog   635 HLKDRHDHKRKRHRRRSYSRER 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xe7	NP_730984.1	RRM_AKAP17A	142..268	CDD:240710	63/126 (50%)
		GBP_C	<275..387	CDD:303769	43/112 (38%)
		coiled coil	356..367	CDD:293879	6/10 (60%)
		coiled coil	376..387	CDD:293879	1/10 (10%)
akap17a	NP_001128287.2	RRM_AKAP17A	143..265	CDD:240710	63/126 (50%)
akap17a	NP_001128287.2	PTZ00121	<229..>438	CDD:173412	79/222 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	346	1.000	Domainoid score	I1040
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2260
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004994
OrthoInspector	1	1.000	-	-		oto105476
Panther	1	1.100	-	-	LDO	PTHR12484
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4206
SonicParanoid	1	1.000	-	-		X4065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090