Protein Alignment Wdr33 and PFS2

DIOPT Version :10

• Sequence 1: NP_730982.1
• Gene: Wdr33 / 40698
• FlyBaseID: FBgn0046222
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_014082.1
• Gene: PFS2 / 855399
• SGDID: S000005261
• Length: 465
• Species: Saccharomyces cerevisiae
• Alignment Length: 486
• Identity: 168/486 - (34%)
• Similarity: 255/486 - (52%)
• Gaps: 78/486 - (16%)

  Fly    46 HGYNQFKPFMPGGFQRPFGMSQDDFDGKRLRKSV-MRKTVDYNASIIKALENRLYQRDYRDRLAL 109
            |..||::.      |.....||.    ..|:|.| .|::||.::..|....||   |.....|.:
Yeast     4 HNQNQYQN------QNQIQQSQQ----PPLKKYVTQRRSVDVSSPYINLYYNR---RHGLPNLVV 55

  Fly   110 QPDSIYVPHMLPPSAY--LDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRLVTGASSGEFTL 172
            :|::.|...::||:||  .|...| :.::|...::||::..|..:.|||||||||....||||:|
Yeast    56 EPETSYTIDIMPPNAYRGRDRVIN-LPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL 119

  Fly   173 WNGLTFNFETILQAHDISVRTMVWSHNDSWMVTGDHGGYVKYWQSNMNNVK-MYQAHKEAIRGIS 236
            ||..:|.|||::||||.:|.||.:||:..||::||..|.:|.||.|.:.|| :..||.|:||.::
Yeast   120 WNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184

  Fly   237 FSPTDSKFVSGSDDGTLRIWDFMRCQEERVLRGHGADVKCVHWHPQKGMIVSGSKDNQQPIKIWD 301
            ||..|||||:.|||..|:||:|...::||||.||..|||...|||:.|:|.|.||||.  :|:||
Yeast   185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL--VKLWD 247

  Fly   302 PKSGIALATLHAHKSTVMDLKWN-DNGNWLVTASRDHLLKLFDIRNLREEVQVFRGHKKEASSVS 365
            |:||..::::...|.||:..::. ..||.|:..|:|...::||||...:|:...| .:.:..::.
Yeast   248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR-DETDYMTLE 311

  Fly   366 WHPIHEGLFCSGGSDGSILFWNV--GTDKEIGCVETAHDSIVWTLAWHPLGHILCSGSNDHTIKF 428
            ||||:|.:|.....|||:..:::  ..::.|..:..|||..:.:|:::|:|||..:.:.|.||:|
Yeast   312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376

  Fly   429 WTRNRPGD--------------------------LMRDKYNLNTLPASLAALDECEYDDAIIPGM 467
            |||.||.|                          .:|:|......|...|.|     :...:|.|
Yeast   377 WTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATL-----EPHALPNM 436

  Fly   468 GPEDRVEFTESLTADKGF--------IPGLD 490
                           .||        |||:|
Yeast   437 ---------------NGFINKKPRQEIPGID 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	120/286 (42%)
		WD40 repeat	149..186	CDD:293791	21/36 (58%)
		WD40 repeat	192..227	CDD:293791	15/35 (43%)
		WD40 repeat	232..268	CDD:293791	19/35 (54%)
		WD40 repeat	275..312	CDD:293791	17/36 (47%)
		WD40 repeat	318..355	CDD:293791	11/37 (30%)
		WD40 repeat	362..398	CDD:293791	10/37 (27%)
		WD40 repeat	405..429	CDD:293791	8/23 (35%)
PFS2	NP_014082.1	WD40	93..377	CDD:238121	120/286 (42%)
		WD40 repeat	98..133	CDD:293791	20/34 (59%)
		WD40 repeat	139..175	CDD:293791	15/35 (43%)
		WD40 repeat	180..216	CDD:293791	19/35 (54%)
		WD40 repeat	223..257	CDD:293791	17/35 (49%)
		WD40 repeat	264..299	CDD:293791	11/34 (32%)
		WD40 repeat	307..346	CDD:293791	10/38 (26%)
		WD40 repeat	353..377	CDD:293791	8/23 (35%)