DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr33 and Wdr77

DIOPT Version :9

Sequence 1:	NP_730982.1	Gene:	Wdr33 / 40698	FlyBaseID:	FBgn0046222	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_081708.1	Gene:	Wdr77 / 70465	MGIID:	1917715	Length:	342	Species:	Mus musculus

Alignment Length:	276	Identity:	68/276 - (24%)
Similarity:	120/276 - (43%)	Gaps:	28/276 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 YLDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRLVTGASSGEFTLWNGLTFNFETILQA--- 186
            :..:||.|....|. :|..:....:..|.|..: :.::..:.||...||. |..| ||::.:
Mouse    60 FFKDPSAAPNEGFC-SAGVQTEAGVADLTWVGD-KGILVASDSGAVELWE-LDEN-ETLIVSKFC 120

  Fly   187 ---HDISVRTMVWSHNDSWMVTGDHGGYVKYW----QSNMNNVKMYQAHKEAIRGISFSP-TDSK 243
               ||..|.|:....:.:..|:|.....:|.|    |.::|:   |:||...:..::.|| .||.
Mouse   121 KYEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSLNS---YRAHAGQVTCVAASPHKDSV 182

  Fly   244 FVSGSDDGTLRIWDFMRCQE---ERVLRGHGADVKCVHWHPQKG-MIVSGSKDNQQPIKIWDPKS 304
            |:|.|:|..:.:|| .||.:   :......|.....:.||||:. :.|.|  |....:.:.|.|:
Mouse   183 FLSCSEDSRILLWD-TRCPKPASQMACNASGYLPTALAWHPQQSEVFVFG--DENGSVSLVDTKN 244

  Fly   305 GIALATLHAHKSTVMDLKWNDNGNWLVTA-SRDHLLKLFDIRNLREEVQVFRGHKKEASSVSWHP 368
            .....:...|...|..|.::.:...|:|: |.|..|.:.|  :...||...|.|:......:|.|
Mouse   245 ASCTLSSAVHSQGVTRLVFSPHSVPLLTSLSEDCSLAVLD--SSLSEVFRSRAHRDFVRDATWSP 307

  Fly   369 IHEGLFCSGGSDGSIL 384
            ::..|..:.|.|..::
Mouse   308 LNHSLLTTVGWDHQVI 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	63/255 (25%)
		WD40	148..>432	CDD:225201	63/253 (25%)
		WD40 repeat	149..186	CDD:293791	10/36 (28%)
		WD40 repeat	192..227	CDD:293791	8/38 (21%)
		WD40 repeat	232..268	CDD:293791	12/39 (31%)
		WD40 repeat	275..312	CDD:293791	9/37 (24%)
		WD40 repeat	318..355	CDD:293791	10/37 (27%)
		WD40 repeat	362..398	CDD:293791	5/23 (22%)
		WD40 repeat	405..429	CDD:293791
Wdr77	NP_081708.1	WD 1	22..75		4/15 (27%)
		WD 2	78..116		10/40 (25%)
		WD40	80..319	CDD:295369	62/249 (25%)
		WD40 repeat	83..120	CDD:293791	10/39 (26%)
		WD40	<98..>322	CDD:225201	61/233 (26%)
		WD 3	123..162		9/38 (24%)
		WD40 repeat	129..164	CDD:293791	7/37 (19%)
		WD 4	165..205		14/40 (35%)
		WD40 repeat	170..207	CDD:293791	12/37 (32%)
		WD 5	209..250		10/42 (24%)
		WD40 repeat	215..256	CDD:293791	10/42 (24%)
		WD 6	253..293		11/41 (27%)
		WD40 repeat	258..282	CDD:293791	7/23 (30%)
		WD 7	295..330		6/29 (21%)
		WD40 repeat	300..333	CDD:293791	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0284
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810