DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr33 and wdr33

DIOPT Version :9

Sequence 1:	NP_730982.1	Gene:	Wdr33 / 40698	FlyBaseID:	FBgn0046222	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001362197.1	Gene:	wdr33 / 548794	XenbaseID:	XB-GENE-6083684	Length:	1598	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	353/647 - (54%)
Similarity:	441/647 - (68%)	Gaps:	77/647 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LATNFTSLPPPNMGGQHYRHYHPHHGSNKHGYNQFKPFMPGGFQRPFGMSQDDFDGKRLRKSVMR 81
            :||...| ||.......::|..|.....|      :|    .:.:...|.|..|||||:||:|.|
Frog     1 MATEIGS-PPRFFHMPRFQHQAPRQLFYK------RP----DYAQQQAMQQLTFDGKRMRKAVNR 54

  Fly    82 KTVDYNASIIKALENRLYQRDYRDRLALQPDSIYVPHMLPPSAYLDNPSNAVTTRFVKTATNKMR 146
            ||:|||.|:||.||||::|||.||..|:|||:.|...::||...::||.|||||:||:|:|||::
Frog    55 KTIDYNPSVIKYLENRVWQRDQRDMRAIQPDAGYYNDLVPPIGMINNPLNAVTTKFVRTSTNKVK 119

  Fly   147 CPIFTLAWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDISVRTMVWSHNDSWMVTGDHGGY 211
            ||:|.:.|||||||||||||||||||||||||||||||||||..||.|.|||||.||:|.||.||
Frog   120 CPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHSGY 184

  Fly   212 VKYWQSNMNNVKMYQAHKEAIRGISFSPTDSKFVSGSDDGTLRIWDFMRCQEERVLRGHGADVKC 276
            |||||||||||||:||||||||..||||||:||.:.|||||:|||||:||.|||:||||||||||
Frog   185 VKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKC 249

  Fly   277 VHWHPQKGMIVSGSKDNQQPIKIWDPKSGIALATLHAHKSTVMDLKWNDNGNWLVTASRDHLLKL 341
            |.|||.||::||||||:|||||.||||:|.:||||||||:|||::|||.|||||:|||||||.||
Frog   250 VDWHPTKGLLVSGSKDSQQPIKFWDPKNGQSLATLHAHKNTVMEVKWNLNGNWLLTASRDHLCKL 314

  Fly   342 FDIRNLREEVQVFRGHKKEASSVSWHPIHEGLFCSGGSDGSILFWNVGTDKEIGCVETAHDSIVW 406
            |||||||||:||||||||||::|:|||:|||||.|||||||:|||:||.:||:|.:|.||:.::|
Frog   315 FDIRNLREELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEIAHEGMIW 379

  Fly   407 TLAWHPLGHILCSGSNDHTIKFWTRNRPGDLMRDKYNLNTLPASLAALDECEYDD------AIIP 465
            :||||||||||||||||||.||||||||||.|||:||||.||.  .:.|..||||      |:||
Frog   380 SLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPG--MSEDGVEYDDIEPNNLAVIP 442

  Fly   466 GMGPEDRVEFT---ESLTADKG-----FIPGLDLDPSKAINDRDR---EKKVPYSKPIPRNFQVN 519
            |||..::::..   |.::.::.     .|||||....:.:....:   :|||||:||||..||..
Frog   443 GMGIPEQLKMAMEQEQMSKEESSSVEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQA 507

  Fly   520 W------------AGPRRADD-------PSVLSIHEELAAREAKDTTN-----GLNHQQISENTM 560
            |            |.|.|.::       .:...|.:|:||.:   .||     .|..::|::...
Frog   508 WMQNKVPLMPPSEAIPDRKEENKSDEKKKNQAEIEQEMAALQ---YTNPQLLEQLKIERIAQKQA 569

  Fly   561 EGILASGMLNGLDPQTIVG--------------VLVYNRFIRVHPDSRLMAAIRQG--AEFL 606
            |   |.|.|.|| |..:.|              :....||.:.||..::....:.|  .:||
Frog   570 E---APGQLQGL-PSPLGGPPHGPSTFQAPGPQLQPTQRFQQPHPTQQMQINAQHGPAGQFL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	223/282 (79%)
		WD40	148..>432	CDD:225201	225/283 (80%)
		WD40 repeat	149..186	CDD:293791	32/36 (89%)
		WD40 repeat	192..227	CDD:293791	27/34 (79%)
		WD40 repeat	232..268	CDD:293791	25/35 (71%)
		WD40 repeat	275..312	CDD:293791	27/36 (75%)
		WD40 repeat	318..355	CDD:293791	30/36 (83%)
		WD40 repeat	362..398	CDD:293791	24/35 (69%)
		WD40 repeat	405..429	CDD:293791	20/23 (87%)
wdr33	NP_001362197.1	WD40	121..402	CDD:238121	222/280 (79%)
		WD40 repeat	122..159	CDD:293791	32/36 (89%)
		WD40 repeat	165..200	CDD:293791	27/34 (79%)
		WD40 repeat	205..241	CDD:293791	25/35 (71%)
		WD40 repeat	248..285	CDD:293791	27/36 (75%)
		WD40 repeat	291..328	CDD:293791	30/36 (83%)
		WD40 repeat	336..372	CDD:293791	24/35 (69%)
		WD40 repeat	378..402	CDD:293791	20/23 (87%)
		PAT1	<479..>646	CDD:370676	38/156 (24%)
		Med15	566..>973	CDD:312941	15/66 (23%)
		Med15	905..>1265	CDD:312941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3639
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	715	1.000	Inparanoid score	I629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188586at33208
OrthoFinder	1	1.000	-	-		FOG0004678
OrthoInspector	1	1.000	-	-		oto104348
Panther	1	1.100	-	-	LDO	PTHR22836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.070