DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr33 and pfs-2

DIOPT Version :9

Sequence 1:	NP_730982.1	Gene:	Wdr33 / 40698	FlyBaseID:	FBgn0046222	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001380152.1	Gene:	pfs-2 / 175092	WormBaseID:	WBGene00011051	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	853	Identity:	304/853 - (35%)
Similarity:	426/853 - (49%)	Gaps:	168/853 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HYHPHHGSNKHGYNQFKPFMPGGFQRPFGMS--QDDFDGKRLRKSV--MRKTVDYNASIIKALEN 96
            |:|||:                .|||...|.  ..|..|:||||:|  :|:.|||.::::...||
Worm    36 HHHPHN----------------RFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVLNHCEN 84

  Fly    97 RLYQRDYRDRLALQPDSIYVPHMLPPSAYLDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRL 161
            ||:|.. :.|:..|||.:|..:.:|..:..|.|.:.:.|:|::||.||::||::::.|:|||:||
Worm    85 RLWQYG-KQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRL 148

  Fly   162 VTGASSGEFTLWNGLTFNFETILQAHDISVRTMVWSHNDSWMVTGDHGGYVKYWQSNMNNVKMYQ 226
            :||..:||||||||..|||||||||||.::|.:.|:.|:.|:::.|.||||||||.||||..|:.
Worm   149 ITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFS 213

  Fly   227 AHK-EAIRGISFSPTDSKFVSGSDDGTLRIWDFMRCQEERVLRGHGADVKCVHWHPQKGMIVSGS 290
            ||| |||||::|:|||.||.:.|||||.|:|||.|..||||||||||:|:|:.|||.||:|.:||
Worm   214 AHKDEAIRGLAFAPTDVKFATASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGS 278

  Fly   291 KDNQQPIKIWDPKSGIALATLHAHKSTVMDLKWNDNGNWLVTASRDHLLKLFDIRNLREEVQVFR 355
            :|.|||:||||||||..||||..|||:||.:::|.|||||:|..||||:|::||| :.:|::.:|
Worm   279 RDTQQPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIR-MMKEMRTYR 342

  Fly   356 GHKKEASSVSWHPIHEGLFCSGGSDGSILFWNVGTDKEIGCVETAHDSIVWTLAWHPLGHILCSG 420
            .||||..|::|||||||||.|||.||||::|.|..:||||.:|.|||..:|::.||||||||.:|
Worm   343 AHKKEVISLAWHPIHEGLFVSGGGDGSIVYWMVDGEKEIGLLEHAHDQAIWSMKWHPLGHILATG 407

  Fly   421 SNDHTIKFWTRNRPGDLMRDKYNL-NTLPASLAALDECEYDDAIIPGMGPEDRVEFTESLTADKG 484
            |||:..|||.||||||.:.|.:.| ||  ..:..||: |.:..:.|   |:..:|..|:...|.
Worm   408 SNDNNTKFWARNRPGDTVEDIFGLSNT--NMIGHLDK-EREPRMAP---PKPSIETQETYRPDT- 465

  Fly   485 FIPGLDLDPS--KAIN----------------DRDREK------------KVPYSKPIPRNFQVN 519
            ||||:.||..  :.:|                |..|:.            |.|.:|...|.|:..
Worm   466 FIPGMGLDEHLYEQLNRDHNMMTTDSTLLVPDDLTRQNFAPMIGAKRTLIKQPPAKKAQRQFERM 530

  Fly   520 WAGPRRADDPSVLSIHEELAAREAKDTTNGLNHQQISENTMEGILASGMLNGLDPQTIVGVLVYN 584
            |                        :.:.|:........||:|        ||..:...|.
Worm   531 W------------------------NNSKGIGAGSDDFTTMKG--------GLGREDAEGA---- 559

  Fly   585 RFIRVHPDSRLMAAIRQGAEFLNKYIDAGKLEELNDVVPVRDRS------RSVSPTVEARGEMVS 643
               :..|....:.....|...|..  ...:.:|...|.|.:.:.      |...|.:...|:...
Worm   560 ---QFGPSKSFLGPPTTGGSLLGP--SQPRPQEFRSVPPPQQQQGPPPNWRHQGPPMSGPGQGYG 619

  Fly   644 PPTKKSRFEPRQHNAQLVCVRELMQCKKP-------------------FLQSLVAAKAQQPNTEF 689
            ||   .|....|...|          :.|                   .||...|::...|..:.
Worm   620 PP---GRMGGNQGGWQ----------RPPPQGSYGGQGPPQGSYGGQGTLQGSYASQQGPPPRQI 671

  Fly   690 VDEP-PLEQRDRDREREGDRDRERERARERERDQSGGRPNPWASNAPWSN--------------- 738
            ...| .::.|.......|.......|.....:..| |.|..|....|.|:
Worm   672 QHIPSDIDYRTAPSSSNGSTGDVDMRTMVPNQPPS-GEPEHWRGPPPVSHQQQSQQQHPPPINMQ 735

  Fly   739 ----NGNPGGNGNGSNGFSNNG---AESFNDRDRGGGGQ---RRRRGINNSGPGNGGGSGGGGGG 793
                ..:|......|:..|.:|   .:..:...:||..|   :...| .|...||..|:.|||.|
Worm   736 RMDPRRDPRMLSGRSDQLSPSGPPPQQQQSSAQQGGKNQWMPQFEAG-QNQNQGNYAGNRGGGVG 799

  Fly   794 GSGRNRGR 801
            |.||.||:
Worm   800 GRGRGRGQ 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	174/283 (61%)
		WD40	148..>432	CDD:225201	175/284 (62%)
		WD40 repeat	149..186	CDD:293791	23/36 (64%)
		WD40 repeat	192..227	CDD:293791	18/34 (53%)
		WD40 repeat	232..268	CDD:293791	23/35 (66%)
		WD40 repeat	275..312	CDD:293791	24/36 (67%)
		WD40 repeat	318..355	CDD:293791	18/36 (50%)
		WD40 repeat	362..398	CDD:293791	23/35 (66%)
		WD40 repeat	405..429	CDD:293791	14/23 (61%)
pfs-2	NP_001380152.1	WD40	135..417	CDD:238121	174/282 (62%)
		WD40 repeat	136..173	CDD:293791	23/36 (64%)
		WD40 repeat	179..215	CDD:293791	18/35 (51%)
		WD40 repeat	220..256	CDD:293791	23/35 (66%)
		WD40 repeat	263..300	CDD:293791	24/36 (67%)
		WD40 repeat	306..342	CDD:293791	18/36 (50%)
		WD40 repeat	348..385	CDD:293791	23/36 (64%)
		WD40 repeat	392..416	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157372
Domainoid	1	1.000	119	1.000	Domainoid score	I3609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I668
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188586at33208
OrthoFinder	1	1.000	-	-		FOG0004678
OrthoInspector	1	1.000	-	-		oto17349
orthoMCL	1	0.900	-	-		OOG6_102397
Panther	1	1.100	-	-	LDO	PTHR22836
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900