Protein Alignment Wdr33 and pfs-2

DIOPT Version :10

• Sequence 1: NP_730982.1
• Gene: Wdr33 / 40698
• FlyBaseID: FBgn0046222
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001380152.1
• Gene: pfs-2 / 175092
• WormBaseID: WBGene00011051
• Length: 809
• Species: Caenorhabditis elegans
• Alignment Length: 853
• Identity: 304/853 - (35%)
• Similarity: 426/853 - (49%)
• Gaps: 168/853 - (19%)

  Fly    36 HYHPHHGSNKHGYNQFKPFMPGGFQRPFGMS--QDDFDGKRLRKSV--MRKTVDYNASIIKALEN 96
            |:|||:                .|||...|.  ..|..|:||||:|  :|:.|||.::::...||
 Worm    36 HHHPHN----------------RFQREHVMPDVMGDGPGRRLRKNVANVRRHVDYVSTVLNHCEN 84

  Fly    97 RLYQRDYRDRLALQPDSIYVPHMLPPSAYLDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRL 161
            ||:|.. :.|:..|||.:|..:.:|..:..|.|.:.:.|:|::||.||::||::::.|:|||:||
 Worm    85 RLWQYG-KQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKCPVYSVCWSPEGKRL 148

  Fly   162 VTGASSGEFTLWNGLTFNFETILQAHDISVRTMVWSHNDSWMVTGDHGGYVKYWQSNMNNVKMYQ 226
            :||..:||||||||..|||||||||||.::|.:.|:.|:.|:::.|.||||||||.||||..|:.
 Worm   149 ITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWASNEQWLLSADQGGYVKYWQPNMNNAHMFS 213

  Fly   227 AHK-EAIRGISFSPTDSKFVSGSDDGTLRIWDFMRCQEERVLRGHGADVKCVHWHPQKGMIVSGS 290
            ||| |||||::|:|||.||.:.|||||.|:|||.|..||||||||||:|:|:.|||.||:|.:||
 Worm   214 AHKDEAIRGLAFAPTDVKFATASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGS 278

  Fly   291 KDNQQPIKIWDPKSGIALATLHAHKSTVMDLKWNDNGNWLVTASRDHLLKLFDIRNLREEVQVFR 355
            :|.|||:||||||||..||||..|||:||.:::|.|||||:|..||||:|::||| :.:|::.:|
 Worm   279 RDTQQPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIR-MMKEMRTYR 342

  Fly   356 GHKKEASSVSWHPIHEGLFCSGGSDGSILFWNVGTDKEIGCVETAHDSIVWTLAWHPLGHILCSG 420
            .||||..|::|||||||||.|||.||||::|.|..:||||.:|.|||..:|::.||||||||.:|
 Worm   343 AHKKEVISLAWHPIHEGLFVSGGGDGSIVYWMVDGEKEIGLLEHAHDQAIWSMKWHPLGHILATG 407

  Fly   421 SNDHTIKFWTRNRPGDLMRDKYNL-NTLPASLAALDECEYDDAIIPGMGPEDRVEFTESLTADKG 484
            |||:..|||.||||||.:.|.:.| ||  ..:..||: |.:..:.|   |:..:|..|:...|.
 Worm   408 SNDNNTKFWARNRPGDTVEDIFGLSNT--NMIGHLDK-EREPRMAP---PKPSIETQETYRPDT- 465

  Fly   485 FIPGLDLDPS--KAIN----------------DRDREK------------KVPYSKPIPRNFQVN 519
            ||||:.||..  :.:|                |..|:.            |.|.:|...|.|:..
 Worm   466 FIPGMGLDEHLYEQLNRDHNMMTTDSTLLVPDDLTRQNFAPMIGAKRTLIKQPPAKKAQRQFERM 530

  Fly   520 WAGPRRADDPSVLSIHEELAAREAKDTTNGLNHQQISENTMEGILASGMLNGLDPQTIVGVLVYN 584
            |                        :.:.|:........||:|        ||..:...|.
 Worm   531 W------------------------NNSKGIGAGSDDFTTMKG--------GLGREDAEGA---- 559

  Fly   585 RFIRVHPDSRLMAAIRQGAEFLNKYIDAGKLEELNDVVPVRDRS------RSVSPTVEARGEMVS 643
               :..|....:.....|...|..  ...:.:|...|.|.:.:.      |...|.:...|:...
 Worm   560 ---QFGPSKSFLGPPTTGGSLLGP--SQPRPQEFRSVPPPQQQQGPPPNWRHQGPPMSGPGQGYG 619

  Fly   644 PPTKKSRFEPRQHNAQLVCVRELMQCKKP-------------------FLQSLVAAKAQQPNTEF 689
            ||   .|....|...|          :.|                   .||...|::...|..:.
 Worm   620 PP---GRMGGNQGGWQ----------RPPPQGSYGGQGPPQGSYGGQGTLQGSYASQQGPPPRQI 671

  Fly   690 VDEP-PLEQRDRDREREGDRDRERERARERERDQSGGRPNPWASNAPWSN--------------- 738
            ...| .::.|.......|.......|.....:..| |.|..|....|.|:
 Worm   672 QHIPSDIDYRTAPSSSNGSTGDVDMRTMVPNQPPS-GEPEHWRGPPPVSHQQQSQQQHPPPINMQ 735

  Fly   739 ----NGNPGGNGNGSNGFSNNG---AESFNDRDRGGGGQ---RRRRGINNSGPGNGGGSGGGGGG 793
                ..:|......|:..|.:|   .:..:...:||..|   :...| .|...||..|:.|||.|
 Worm   736 RMDPRRDPRMLSGRSDQLSPSGPPPQQQQSSAQQGGKNQWMPQFEAG-QNQNQGNYAGNRGGGVG 799

  Fly   794 GSGRNRGR 801
            |.||.||:
 Worm   800 GRGRGRGQ 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	174/283 (61%)
		WD40 repeat	149..186	CDD:293791	23/36 (64%)
		WD40 repeat	192..227	CDD:293791	18/34 (53%)
		WD40 repeat	232..268	CDD:293791	23/35 (66%)
		WD40 repeat	275..312	CDD:293791	24/36 (67%)
		WD40 repeat	318..355	CDD:293791	18/36 (50%)
		WD40 repeat	362..398	CDD:293791	23/35 (66%)
		WD40 repeat	405..429	CDD:293791	14/23 (61%)
pfs-2	NP_001380152.1	WD40	135..417	CDD:238121	174/282 (62%)
		WD40 repeat	136..173	CDD:293791	23/36 (64%)
		WD40 repeat	179..215	CDD:293791	18/35 (51%)
		WD40 repeat	220..256	CDD:293791	23/35 (66%)
		WD40 repeat	263..300	CDD:293791	24/36 (67%)
		WD40 repeat	306..342	CDD:293791	18/36 (50%)
		WD40 repeat	348..385	CDD:293791	23/36 (64%)
		WD40 repeat	392..416	CDD:293791	14/23 (61%)