DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr33 and wdr77

DIOPT Version :9

Sequence 1:	NP_730982.1	Gene:	Wdr33 / 40698	FlyBaseID:	FBgn0046222	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001120009.1	Gene:	wdr77 / 100144971	XenbaseID:	XB-GENE-972898	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	287	Identity:	61/287 - (21%)
Similarity:	117/287 - (40%)	Gaps:	50/287 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 PPSAYLDNPSNAVTTRFVKTATNKMRCPIFTLAWTPEGRRLVTGASSGEFTLWNGLTFNFETIL- 184
            |.||    |:.::.|..|:|...     :..:||..| :.::..:.||...||..|  ..|::|
Frog    54 PDSA----PNESLCTAGVQTEAG-----VTDVAWVSE-KGILVASDSGAVELWEIL--EKESLLV 106

  Fly   185 -----QAHDISVRTMVWSHNDSWMVTGDHGGYVKYWQSNMNN-VKMYQAHKEAIRGISFSP-TDS 242
                 ..||..|:::....:.:..|:|.....||.|...... :..|.||...:..::..| .::
Frog   107 NKFTKYEHDDIVKSLSVFSDGTQAVSGGKDFSVKVWDLTQKTLLNSYIAHSSEVNCVAACPGKEA 171

  Fly   243 KFVSGSDDGTLRIWDFMRCQEERVLRGHGADV--KCVHWHPQK----------GMIVSGSKDNQQ 295
            .|:|..:||.:.:||..:.:....:.....|.  ..|.|||:|          |.:...:..|..
Frog   172 IFLSCGEDGKILLWDTRKPKPATRIDFFTPDTIPTSVTWHPEKDDTFACGDEIGNVYLVNLKNLD 236

  Fly   296 PIKIWDPKSGIALATLHAHKSTVMDLKWNDNGN-WLVTASRDHLLKLFDIRNLREEVQVFR--GH 357
            .::    ||.:       |..::..|.::.:.: :|.:.|.|..:.::|    .:..:.||  .|
Frog   237 SVQ----KSSV-------HSQSITGLAYSYHSSPYLASISEDCTVAVYD----SDFSEAFRDLSH 286

  Fly   358 KKEASSVSWHPIHEGLFCSGGSDGSIL 384
            :...:.|:|.|:....|.:.|.|..:|
Frog   287 RDFVTGVAWSPLDHSKFTTVGWDHKVL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr33	NP_730982.1	WD40	146..429	CDD:238121	54/262 (21%)
		WD40	148..>432	CDD:225201	54/260 (21%)
		WD40 repeat	149..186	CDD:293791	10/42 (24%)
		WD40 repeat	192..227	CDD:293791	6/35 (17%)
		WD40 repeat	232..268	CDD:293791	7/36 (19%)
		WD40 repeat	275..312	CDD:293791	9/46 (20%)
		WD40 repeat	318..355	CDD:293791	5/37 (14%)
		WD40 repeat	362..398	CDD:293791	7/23 (30%)
		WD40 repeat	405..429	CDD:293791
wdr77	NP_001120009.1	WD40	<43..312	CDD:225201	60/284 (21%)
		WD40	70..>297	CDD:295369	49/249 (20%)
		WD40 repeat	73..110	CDD:293791	10/39 (26%)
		WD40 repeat	119..154	CDD:293791	5/34 (15%)
		WD40 repeat	160..197	CDD:293791	7/36 (19%)
		WD40 repeat	205..242	CDD:293791	8/40 (20%)
		WD40 repeat	248..273	CDD:293791	4/24 (17%)
		WD40 repeat	290..312	CDD:293791	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910