DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED27 and MED27

DIOPT Version :9

Sequence 1:	NP_649569.1	Gene:	MED27 / 40696	FlyBaseID:	FBgn0037359	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	XP_016870818.1	Gene:	MED27 / 9442	HGNCID:	2377	Length:	341	Species:	Homo sapiens

Alignment Length:	330	Identity:	118/330 - (35%)
Similarity:	186/330 - (56%)	Gaps:	39/330 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKLNSTLTAVKNLRSNVRLCFEHLADGTDGESGEESRNK-FVNDFQERFAAINSQIREVEQLIN 64
            ::..:..::|::.|||:|...|:.|.||...:...|.|.| |:..||:...::|..:.|:|:|.|
Human    11 LEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSN 75

  Fly    65 GLPVPPTPYSLGNTAYLAQETSQDRQALYPQLVNSYKWMDKVHDHSFLAFNNLNQNTLRRSYNYC 129
            .:..|...:.|.|:..|:.:..||:..||.||:.:|||.:|:..|:.||...|||.:|:||.|..
Human    76 LVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQM 140

  Fly   130 SQKRQRLPFSSFNN---DPDHIDKLLSEINTP-PHTSYRIFRPFGTNAVTIVTISNVMKAAIVFK 190
            ....:|.|.:....   .|.::|.::|.|:.. |..|..:.||.||:|:.:||:..|:|..:|.:
Human   141 GVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMR 205

  Fly   191 GVLIEWVTVKGFDE----------------------PLEHD------------DLWAESRYEVFR 221
            .:.|:...|||::|                      .|..|            |:|::|.|:||:
Human   206 SLFIDRTIVKGYNENVYTEDGKFFLCVKRSFDVLVFALRTDVSVLKQLVICKLDIWSKSNYQVFQ 270

  Fly   222 KVQDHAHSAMLHFFSPTLPDLAVKSYITWLNSHVKLFLEPCKRCGKFVVNGLPPTWRDLRTLEPF 286
            ||.|||.:|:||:..|.:||:.|:|::|||.|::|||..||:|||||:.:||||||||.||||.|
Human   271 KVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAF 335

  Fly   287 HEDCR 291
            |:.||
Human   336 HDTCR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED27	NP_649569.1	Med27	209..287	CDD:288428	46/89 (52%)
MED27	XP_016870818.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156874
Domainoid	1	1.000	124	1.000	Domainoid score	I5561
eggNOG	1	0.900	-	-		E1_28JSR
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3152
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3463
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48630
OrthoDB	1	1.010	-	-		D1256412at2759
OrthoFinder	1	1.000	-	-		FOG0007494
OrthoInspector	1	1.000	-	-		oto91564
orthoMCL	1	0.900	-	-		OOG6_107387
Panther	1	1.100	-	-	LDO	PTHR13130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4648
SonicParanoid	1	1.000	-	-		X6375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800