DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elm and Chp1

DIOPT Version :9

Sequence 1:	NP_001262295.1	Gene:	elm / 40695	FlyBaseID:	FBgn0037358	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_062743.1	Gene:	Chp1 / 56398	MGIID:	1927185	Length:	195	Species:	Mus musculus

Alignment Length:	196	Identity:	119/196 - (60%)
Similarity:	151/196 - (77%)	Gaps:	8/196 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKSSLFLRNEEIAQIQEETGFTPNQIERLYSRFTSLDRNDCGTLSREDLMRIPELAINPLCER 65
            ||:::|..||:||:.:|::||||:.:||.||||||||||:.:.|||||||..||||||||||.:|
Mouse     1 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDR 65

  Fly    66 IVHSFFAESNDDRVNFRQFMNVLAHFRPLRDNKQSK-------LNSREEKLKFAFKMYDLDDDGV 123
            |:::||:| .:|:||||.||..||||||:.||::||       ||||..||.|||::||||.|..
Mouse    66 IINAFFSE-GEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDDK 129

  Fly   124 ISRDELLSILHMMVGANISQDQLVSIAERTILEADLCCQGKISFEDFCKALDRTDVDQKMSIRFL 188
            |||||||.:|.||||.|||.:||.|||:|||.|||......|||.:|.|.|::.||:||||||||
Mouse   130 ISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFL 194

  Fly   189 N 189
            :
Mouse   195 H 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elm	NP_001262295.1	FRQ1	23..173	CDD:227455	96/156 (62%)
Chp1	NP_062743.1	Nuclear export signal 2. /evidence=ECO:0000250	176..185		3/8 (38%)
		FRQ1	1..182	CDD:227455	109/181 (60%)
		Necessary for association with microtubule and interaction with GAPDH. /evidence=ECO:0000250	2..6		1/3 (33%)
		Nuclear export signal 1. /evidence=ECO:0000250	138..147		5/8 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846959
Domainoid	1	1.000	132	1.000	Domainoid score	I5092
eggNOG	1	0.900	-	-		E2759_KOG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5235
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3452
Isobase	1	0.950	-	0	Normalized mean entropy	S676
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	1	1.000	-	-		FOG0000640
OrthoInspector	1	1.000	-	-		otm44276
orthoMCL	1	0.900	-	-		OOG6_105864
Panther	1	1.100	-	-	LDO	PTHR46002
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3958
SonicParanoid	1	1.000	-	-		X2469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750