DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elm and PPP3R1

DIOPT Version :9

Sequence 1:	NP_001262295.1	Gene:	elm / 40695	FlyBaseID:	FBgn0037358	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_000936.1	Gene:	PPP3R1 / 5534	HGNCID:	9317	Length:	170	Species:	Homo sapiens

Alignment Length:	185	Identity:	69/185 - (37%)
Similarity:	110/185 - (59%)	Gaps:	17/185 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKSSLFLRNEEIAQIQEETGFTPNQIERLYSRFTSLDRNDCGTLSREDLMRIPELAINPLCER 65
            |||::|.        .::..:.|..::|:||..||..||.::.|:||.|:.|.:|||..|||.:|
Human     1 MGNEASY--------PLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQR 57

  Fly    66 IVHSFFAESNDDRVNFRQFMNVLAHFRPLRDNKQSKLNSREEKLKFAFKMYDLDDDGVISRDELL 130
            ::..|..:.|.: |:|::|:..::.|        |....:|:||:|||::||:|.||.||..||.
Human    58 VIDIFDTDGNGE-VDFKEFIEGVSQF--------SVKGDKEQKLRFAFRIYDMDKDGYISNGELF 113

  Fly   131 SILHMMVGANISQDQLVSIAERTILEADLCCQGKISFEDFCKALDRTDVDQKMSI 185
            .:|.||||.|:...||..|.::||:.||....|:||||:||..:...|:.:||.:
Human   114 QVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVV 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elm	NP_001262295.1	FRQ1	23..173	CDD:227455	62/149 (42%)
PPP3R1	NP_000936.1	FRQ1	13..157	CDD:227455	62/152 (41%)
PPP3R1	NP_000936.1	Calcineurin A binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26794871, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	131..136		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	1	1.000	-	-		FOG0000640
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830