DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elm and CHP1

DIOPT Version :9

Sequence 1:	NP_001262295.1	Gene:	elm / 40695	FlyBaseID:	FBgn0037358	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_009167.1	Gene:	CHP1 / 11261	HGNCID:	17433	Length:	195	Species:	Homo sapiens

Alignment Length:	196	Identity:	119/196 - (60%)
Similarity:	150/196 - (76%)	Gaps:	8/196 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKSSLFLRNEEIAQIQEETGFTPNQIERLYSRFTSLDRNDCGTLSREDLMRIPELAINPLCER 65
            ||:::|..||:||:.:|::||||:.:||.||||||||||:.:.|||||||..||||||||||.:|
Human     1 MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDR 65

  Fly    66 IVHSFFAESNDDRVNFRQFMNVLAHFRPLRDNKQSK-------LNSREEKLKFAFKMYDLDDDGV 123
            |:::||.| .:|:||||.||..||||||:.||::||       ||||..||.|||::||||.|..
Human    66 IINAFFPE-GEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEK 129

  Fly   124 ISRDELLSILHMMVGANISQDQLVSIAERTILEADLCCQGKISFEDFCKALDRTDVDQKMSIRFL 188
            |||||||.:|.||||.|||.:||.|||:|||.|||......|||.:|.|.|::.||:||||||||
Human   130 ISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFL 194

  Fly   189 N 189
            :
Human   195 H 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elm	NP_001262295.1	FRQ1	23..173	CDD:227455	96/156 (62%)
CHP1	NP_009167.1	FRQ1	1..182	CDD:227455	109/181 (60%)
		Necessary for association with microtubule and interaction with GAPDH. /evidence=ECO:0000250	2..6		1/3 (33%)
		Nuclear export signal 1. /evidence=ECO:0000250	138..147		5/8 (63%)
		Necessary for nuclear export signal	143..185		22/41 (54%)
		Nuclear export signal 2. /evidence=ECO:0000250	176..185		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156546
Domainoid	1	1.000	131	1.000	Domainoid score	I5167
eggNOG	1	0.900	-	-		E2759_KOG0034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5235
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3486
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	1	1.000	-	-		FOG0000640
OrthoInspector	1	1.000	-	-		otm42221
orthoMCL	1	0.900	-	-		OOG6_105864
Panther	1	1.100	-	-	LDO	PTHR46002
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3958
SonicParanoid	1	1.000	-	-		X2469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800