Protein Alignment Sec23 and NEL1

DIOPT Version :10

• Sequence 1: NP_001246932.1
• Gene: Sec23 / 40694
• FlyBaseID: FBgn0262125
• Length: 781
• Species: Drosophila melanogaster
• Sequence 2: NP_011900.1
• Gene: NEL1 / 856430
• SGDID: S000001077
• Length: 630
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 169/735 - (22%)
• Similarity: 278/735 - (37%)
• Gaps: 177/735 - (24%)

  Fly    37 PLACLYQPLKERPDLPPIQYEPVL-CTRSNCRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAA 100
            |...||:|...  |.....|:..| ||:  |.|..:..|.: ....:|.|.||.|.|
Yeast     4 PTNFLYEPFSS--DAVTQNYDQNLKCTK--CGAYYSMACSL-REQNVWTCLFCNQSN-------- 55

  Fly   101 ISEQHQPAELIPGFSTIEYTITRA--PTMPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNAL 163
             |....|  |:|..:   ||:|.|  ..:....|.::|...|..||:.|       :|:|..|.:
Yeast    56 -SNAELP--LVPSNT---YTLTSAKKEILSRRTIMIIDAICDPHELNYL-------VSILCNNYI 107

  Fly   164 ------VGLITFGKMIQVHELGAEGCSKSYVFRGTKDLTAKQVQDMLGIGRGAAPGPQQQQHLPG 222
                  :.:||..:...|....|....:..|| ...:...|...|.|.
Yeast   108 TRQQEPLSIITIQQSGHVILHNAVNHRRDAVF-SINEFMTKYNLDKLN----------------- 154

  Fly   223 QPAGAAAPVPPAHRFLQPIGQCD-----------AALGDLLSELQRDPWPVP-QGKRYLRSTGAA 275
                       |..|.:.|.:.:           .:|..||.|:.:....|. ..||..|.||.|
Yeast   155 -----------ASYFEKKISEINQESYWFDKSTQGSLRKLLREICKIANKVNISSKRDKRCTGLA 208

  Fly   276 LSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHH--DIHKDNVRFMKKAIKH 338
            |.::..|......:....|::|:.|||::|.|:|:..|....:|.:|  :.....::..|...|.
Yeast   209 LFVSSVLASQCSLSAYCHIVSFLNGPCTKGGGKVMSRERGESMRQNHHFESKSSQLQLSKSPTKF 273

  Fly   339 YDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMG--DSFNSSLFKQTFQRVFARD 401
            |..:..:.|......:.:..:|||.|:|||..|..|:   |.:.  ||||...|..:||:..
Yeast   274 YKKMLEKFANQSLIYEFFIASLDQIGILEMSPLITSS---MAVSQFDSFNDERFAMSFQKYL--- 332

  Fly   402 GRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWKLCTLNPSSTVA 466
            ...|....:|...::..::...:...... .|||.|:.|: .:||.:|:
Yeast   333 NLRDHNAIYNCHSKIMTAKNAIVVKDFPK-YSLNPKNLSL-PLEISLGH---------------- 379

  Fly   467 YFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLA-----RNWADATSNVHHI----- 521
                  |...||        |||.|.:::.: ::.||:.||.     |::......|..:
Yeast   380 ------NSAEAP--------IQFQTTFENQT-EKYIRIETLLLPKANRSFGAQNEIVFSMKKIAS 429

  Fly   522 ----SAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNF 582
                |..:..:....||.::.:.       |:.:|..|..::.|.
Yeast   430 RIIDSFAYSSKHTKELMKQLFLL-------PNQIRGKDVDMVNLI-------------------- 467

  Fly   583 SLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLDT 647
                |:.||:.||..|.|.|.||||...:.|.::.......|.:.:|.::||| :...:.::||.
Yeast   468 ----QWCYHIYRSPILSVRNTSPDERYLFLHRIINASKDTCLSLCKPFIWSYS-DLKHDWIVLDV 527

  Fly   648 ASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPR 712
            ...:|.  :|.|....|.:..|    .:..|:...:.|.|. ::|....::|.|     |||.|.
Yeast   528 PLTRAQ--ILQDDKTTICVDGG----SYLVLRRGKLLEKEG-RELCCKLLNDLQ-----RFPQPL 580

  Fly   713 YIDTEHGGSQARFLLSKVNP 732
            |::|:.||||.|||.||:.|
Yeast   581 YVETKTGGSQDRFLKSKIIP 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	169/735 (23%)
NEL1	NP_011900.1	SEC23	1..630	CDD:227380	169/735 (23%)