DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec23 and AT1G05520

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_563741.1	Gene:	AT1G05520 / 837054	AraportID:	AT1G05520	Length:	783	Species:	Arabidopsis thaliana

Alignment Length:	794	Identity:	379/794 - (47%)
Similarity:	511/794 - (64%)	Gaps:	46/794 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSNCRAILNPLCQV 76
            |..||||:||||||.:::|||:.|:|:|....|::...|:|.::|.|:.|  ..|.|.|||..:|
plant    10 EGIDGVRMTWNVWPRTKVEASKCVIPVAACISPIRYHRDIPSVEYAPLRC--RICTAALNPFARV 72

  Fly    77 DYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITR--APT------------- 126
            |:.||:|:|..|||||.|||.|..:||.:.|.||.|.::|:|||:..  .||
plant    73 DFLAKIWICPICFQRNHFPPHYHVMSETNVPCELYPQYTTVEYTLPNPSQPTGVGNFDQTGAVSG 137

  Fly   127 --MPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVF 189
              .|.||:|::||||.|||....|.:|:.::.|||.|||||.::||....|||||....:|.|||
plant   138 QPSPSVFVFVLDTCMIEEEFGYAKSALKQAIGLLPENALVGFVSFGTQAHVHELGFSDLTKVYVF 202

  Fly   190 RGTKDLTAKQVQDMLGIGRGAAPGPQQQQHLPGQPAG----AAAPVPPAHRFLQPIGQCDAALGD 250
            ||.|:::..||.:.||:|......|     :.|.|.|    |.......:|||.|...|:..:..
plant   203 RGDKEISKDQVLEQLGLGASGRRNP-----VGGFPMGRDNSANFGYSGVNRFLLPASDCEFTIDL 262

  Fly   251 LLSELQRDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELK 315
            ||.|||.|.|||..|:|..|.||.|:|:|.|||...:|.||.||:..:|||||:|||.:|..:|.
plant   263 LLEELQTDQWPVQAGRRQSRCTGVAISVATGLLGACFPGTGARIVALIGGPCSEGPGTIVSKDLS 327

  Fly   316 HPIRSHHDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMV 380
            .|:|||.|:.||...|.|||.|.|||||.:....||.:|:::.||||.|:.|||.....|||.:|
plant   328 EPLRSHKDLDKDAAPFYKKAEKFYDALANQLVNQGHVLDLFASALDQVGVAEMKAAVERTGGLVV 392

  Fly   381 MGDSFNSSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVE 445
            :.:||..|:||.:|:||| .||...|.:.||.|||:.||:::||.|.||.|.||..|.|||:|..
plant   393 LSESFGHSVFKDSFKRVF-EDGEESLGLCFNGTLEICCSKDIKIQGIIGPCASLQKKGPSVADTV 456

  Fly   446 IGMGNTVQWKLCTLNPSSTVAYFFEV--VNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLA 508
            ||.|||.|||:|.|:..:.:..||::  .:|.:||.....:..:||:|.||:..|:...||||:.
plant   457 IGEGNTTQWKMCGLDKRTCLTVFFDLSSSDQSSAPGGVNNQLYLQFMTSYQNSKGKTLQRVTTVT 521

  Fly   509 RNWADATSNVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDP 573
            |.|.|...:...:..|||||.|||::||:...:.||:||.|..||:||.|||||.|||:|.||||
plant   522 RQWVDTGLSTEELVQGFDQETAAVVVARLASLKMETEEGFDATRWLDRNLIRLCSKFGDYRKDDP 586

  Fly   574 NSFRLSQNFSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNG 638
            .||.|:.||||||||.::||||||:||||||||||.:.|.:|.||:::.:.:||||.|.:||||.
plant   587 ASFTLNPNFSLFPQFTFNLRRSQFVQVFNNSPDETAYNRMLLNRENISNAAVMIQPSLTTYSFNS 651

  Fly   639 PPEPVLLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEI 703
            .|:|.|||.|||.||||||:|::..::::||.||||||.|.||:.||::.|.|||:||.:|||.|
plant   652 LPQPALLDVASIGADRILLLDSYISVVVFHGMTIAQWRNLGYQNQPEHQAFAQLLEAPQEDAQMI 716

  Fly   704 LQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNN---MYAYGQAPIGQVTVDGGAPVLTDDVSL 765
            ::.|||:||.:..:..||||||||:|:|||.|:||   |.|            |...:.||||||
plant   717 IRDRFPVPRLVVCDQHGSQARFLLAKLNPSATYNNASEMNA------------GSDIIFTDDVSL 769

  Fly   766 QLFMEHLKKLAVST 779
            |:|.:||:||||.:
plant   770 QVFFQHLQKLAVQS 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	379/792 (48%)
		zf-Sec23_Sec24	58..97	CDD:282641	20/38 (53%)
		Sec23-like	126..396	CDD:238755	124/288 (43%)
		Sec23_BS	409..512	CDD:285301	46/104 (44%)
		Sec23_helical	530..623	CDD:282646	58/92 (63%)
		Sec23_C	618..738	CDD:200443	66/119 (55%)
AT1G05520	NP_563741.1	PLN00162	4..783	CDD:215083	379/792 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	259	1.000	Domainoid score	I490
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	742	1.000	Inparanoid score	I111
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D270617at2759
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm2812
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	O	PTHR11141
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840