DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and sec23b

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001016850.1	Gene:	sec23b / 549604	XenbaseID:	XB-GENE-974663	Length:	767	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	573/788 - (72%)
Similarity:	655/788 - (83%)	Gaps:	28/788 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSN 65
            |.||.|||||||:|||||.:||||||||:||:|:||||.||:.||||||||||:|||||||||..
Frog     1 MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLGCLFTPLKERPDLPPVQYEPVLCTRPT 65

  Fly    66 CRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPV 130
            |:|:||||||||||||||.||||||||.|||.||.|||.:|||||:|.||||||.:.|.|..|.|
Frog    66 CKAVLNPLCQVDYRAKLWACNFCFQRNQFPPTYAGISEVNQPAELMPQFSTIEYIVQRGPQTPLV 130

  Fly   131 FIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDL 195
            |:::||||::||:|.|||:||||||||||.:|||||||||:|:|||||..:|.||||||||||||
Frog   131 FLYVVDTCLEEEDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCDGISKSYVFRGTKDL 195

  Fly   196 TAKQVQDMLGIGRGAAPG-------PQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLS 253
            ||||:|||||:.:.|||.       ||:|..|             :.|||||:.:.|..|.|||.
Frog   196 TAKQIQDMLGLSKAAAPAQQGRPLQPQEQPFL-------------SSRFLQPVHKIDMNLTDLLG 247

  Fly   254 ELQRDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPI 318
            ||||||||||||||.|||||.||||||||||.|.||||.|||.|.|||.:||||.||.||||.||
Frog   248 ELQRDPWPVPQGKRPLRSTGVALSIAVGLLEGTLPNTGARIMLFTGGPPTQGPGMVVGDELKTPI 312

  Fly   319 RSHHDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGD 383
            ||.|||.|||.||||||.|||:|||.|.|.|||.:|||:||||||||||||...|.|||.:|:||
Frog   313 RSWHDIEKDNARFMKKATKHYEALANRTAANGHCIDIYACALDQTGLLEMKCCSNLTGGEIVIGD 377

  Fly   384 SFNSSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGM 448
            |||:|||||||||||.:|.....||||.|.|:||.|||||:||.||.||||||..|.||:.|:|:
Frog   378 SFNTSLFKQTFQRVFTKDPNGSFKMAFGANLDVKTSRELKVSGTIGPCVSLNVNGPCVSENELGV 442

  Fly   449 GNTVQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWAD 513
            |.|.|||:|.|:|::|:..:|||||||.|||||||||.:||:|||||.:.|:||||||:||||||
Frog   443 GGTSQWKICALDPTTTLGIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSTTQKRIRVTTVARNWAD 507

  Fly   514 ATSNVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRL 578
            |.|.:.||.|.||||||||||||:.||||||:||||:|||:||||||||||||:|:||||:||||
Frog   508 AQSQIQHIEAAFDQEAAAVLMARLGVYRAETEEGPDVLRWLDRQLIRLCQKFGQYNKDDPSSFRL 572

  Fly   579 SQNFSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPV 643
            |.:|||:||||:|||||.|||||||||||:::|||...|:||||||||||||||||||.||||||
Frog   573 SDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPILYSYSFYGPPEPV 637

  Fly   644 LLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRF 708
            |||::||.|||||||||||||:||.||||||||...|.|||||||||||||||:||||||||:||
Frog   638 LLDSSSILADRILLMDTFFQIVIYLGETIAQWRNAGYHDMPEYENFKQLLQAPLDDAQEILQSRF 702

  Fly   709 PMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLK 773
            ||||||:|||||||||||||||||||||||:|.:||        :.|||:||||||||:||:|||
Frog   703 PMPRYINTEHGGSQARFLLSKVNPSQTHNNLYNWGQ--------ESGAPILTDDVSLQVFMDHLK 759

  Fly   774 KLAVSTTT 781
            ||||||.:
Frog   760 KLAVSTAS 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	562/773 (73%)
		zf-Sec23_Sec24	58..97	CDD:282641	32/38 (84%)
		Sec23-like	126..396	CDD:238755	187/276 (68%)
		Sec23_BS	409..512	CDD:285301	68/102 (67%)
		Sec23_helical	530..623	CDD:282646	72/92 (78%)
		Sec23_C	618..738	CDD:200443	105/119 (88%)
sec23b	NP_001016850.1	PLN00162	12..765	CDD:215083	562/773 (73%)
		zf-Sec23_Sec24	58..96	CDD:282641	31/37 (84%)
		Sec23-like	126..390	CDD:238755	187/276 (68%)
		Sec23_BS	403..506	CDD:285301	68/102 (67%)
		Sec23_helical	524..617	CDD:282646	72/92 (78%)
		Sec23_C	612..732	CDD:200443	105/119 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	376	1.000	Domainoid score	I859
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1182	1.000	Inparanoid score	I200
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm48546
Panther	1	1.100	-	-	O	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110