DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and sec23a

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_998630.1	Gene:	sec23a / 406774	ZFINID:	ZDB-GENE-040426-2823	Length:	765	Species:	Danio rerio

Alignment Length:	783	Identity:	573/783 - (73%)
Similarity:	661/783 - (84%)	Gaps:	24/783 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSN 65
            |.|::|||||||||||||.:||||||||:||:|:|||:|.|:.||||||||||||||||||:|:.
Zfish     1 MATFQEFIQQNEDRDGVRFSWNVWPSSRLEATRMVVPVASLFTPLKERPDLPPIQYEPVLCSRAT 65

  Fly    66 CRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPV 130
            |||:||||||||||||||.||||:|||.|||.||.|||.:|||||:|.||||||.:.|.|.||..
Zfish    66 CRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISEVNQPAELLPQFSTIEYVVQRGPQMPLN 130

  Fly   131 FIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDL 195
            |:::|||||::::|.|||:||||||||||..|||||||||:|:||||||.||.||||||||||||
Zfish   131 FLYVVDTCMEDDDLQALKESLQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDL 195

  Fly   196 TAKQVQDMLGIGRGAAP----GPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQ 256
            .|||:|:|||:.:.||.    ||||.|            |||::|||||:.:.|..|.|||.|||
Zfish   196 NAKQLQEMLGLTKPAAAQAGRGPQQPQ------------VPPSNRFLQPVQKIDMNLTDLLGELQ 248

  Fly   257 RDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSH 321
            ||||||.||||.|||.|.||||||||||||:||||.|||.|:|||.:||||.||.||||.||||.
Zfish   249 RDPWPVTQGKRPLRSLGVALSIAVGLLECTFPNTGARIMAFIGGPATQGPGMVVGDELKTPIRSW 313

  Fly   322 HDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFN 386
            |||.|||.:|||||.|||:|||.|||.|||.:|||:||||||||||||...|.|||:|||.||||
Zfish   314 HDIEKDNAKFMKKATKHYEALANRAAANGHIIDIYACALDQTGLLEMKCCTNYTGGYMVMADSFN 378

  Fly   387 SSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNT 451
            :|||||||||||.:|.:...|||...|||:|.|||:||||.||.|||||.|.|.||:.|:|.|.|
Zfish   379 TSLFKQTFQRVFTKDVQGCFKMALAGTLEIKTSREIKISGAIGPCVSLNAKGPCVSENEMGTGGT 443

  Fly   452 VQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATS 516
            .|||:|.|:|::|:.::|||||||.|||||||||.||::|||||.||||||||||:|||||||.|
Zfish   444 SQWKICGLDPNTTLGFYFEVVNQHNAPIPQGGRGAIQYVTQYQHSSGQRRIRVTTIARNWADAQS 508

  Fly   517 NVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQN 581
            .:..|:|.|||||||:||||:.||:|||:||||:|||:||||||||||||:|.|:||||||.|:.
Zfish   509 QIQSIAASFDQEAAAILMARLAVYKAETEEGPDVLRWLDRQLIRLCQKFGDYHKEDPNSFRFSET 573

  Fly   582 FSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLD 646
            |||:||||:|||||.|||||||||||:|:|||..||:||||||||:|||||:|||||||||||||
Zfish   574 FSLYPQFMFHLRRSPFLQVFNNSPDESTYYRHQFMRQDLTQSLIMVQPILYAYSFNGPPEPVLLD 638

  Fly   647 TASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMP 711
            ::||..|||||||||||||||||||::|||...||||||||||:.|||||||||||:|.||||||
Zfish   639 SSSILPDRILLMDTFFQILIYHGETVSQWRKAGYQDMPEYENFRHLLQAPVDDAQELLHTRFPMP 703

  Fly   712 RYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLKKLA 776
            ||||||||||||||||||||||||||||||:||        :.|||:||||||||:||:||||||
Zfish   704 RYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQ--------ESGAPILTDDVSLQVFMDHLKKLA 760

  Fly   777 VST 779
            ||:
Zfish   761 VSS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	564/770 (73%)
		zf-Sec23_Sec24	58..97	CDD:282641	31/38 (82%)
		Sec23-like	126..396	CDD:238755	189/273 (69%)
		Sec23_BS	409..512	CDD:285301	70/102 (69%)
		Sec23_helical	530..623	CDD:282646	71/92 (77%)
		Sec23_C	618..738	CDD:200443	103/119 (87%)
sec23a	NP_998630.1	PLN00162	12..763	CDD:215083	564/770 (73%)
		zf-Sec23_Sec24	58..96	CDD:282641	30/37 (81%)
		Sec23-like	126..388	CDD:238755	189/273 (69%)
		Sec23_BS	401..504	CDD:285301	70/102 (69%)
		Sec23_helical	522..615	CDD:282646	71/92 (77%)
		Sec23_C	610..730	CDD:200443	103/119 (87%)
		Gelsolin-like. /evidence=ECO:0000255	632..718		72/85 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586691
Domainoid	1	1.000	379	1.000	Domainoid score	I806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4642
Inparanoid	1	1.050	1189	1.000	Inparanoid score	I189
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm26458
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	LDO	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940