DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and sec231

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_587900.1	Gene:	sec231 / 2538699	PomBaseID:	SPCC31H12.07	Length:	759	Species:	Schizosaccharomyces pombe

Alignment Length:	779	Identity:	447/779 - (57%)
Similarity:	563/779 - (72%)	Gaps:	24/779 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSNCRA 68
            :||.    |:|||||.||||:||:|||:||.:||:|.:|:||.|||||||:.||||.| ::.|:|
pombe     3 FEEI----EERDGVRFTWNVFPSTRIESSRTIVPIASIYKPLNERPDLPPVLYEPVTC-KAPCKA 62

  Fly    69 ILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPVFIF 133
            :|||.|.:|.|||.|:|.||.|||..||||..||....|.||:|.:||||||:.|.|.:.|||:|
pombe    63 VLNPYCHIDTRAKFWICPFCLQRNMLPPQYKDISNTSLPIELLPEYSTIEYTLPRPPQLTPVFLF 127

  Fly   134 LVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDLTAK 198
            :||.|.|||.|.||||||.:||||||...||||:|||.|:.|:|||...|||||||||:||.|:|
pombe   128 VVDVCQDEENLQALKDSLIISLSLLPPECLVGLVTFGTMVDVYELGYTECSKSYVFRGSKDYTSK 192

  Fly   199 QVQDMLGIGRGAAPGPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQRDPWPVP 263
            |:|:|||:..........||....|  |:|||    .|||.||.||:..|.::|.:||.|.|||.
pombe   193 QIQEMLGLPTSNVSPVALQQARSFQ--GSAAP----SRFLLPIQQCEFQLTNILEQLQPDSWPVA 251

  Fly   264 QGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHHDIHKDN 328
            ..:|..|.||.||:|:|.::|...||:||.||.|.|||.:.|||.||..||:.||||||||.:|.
pombe   252 NDRRPQRCTGTALNISVSMMESVCPNSGGHIMLFAGGPSTVGPGTVVSTELREPIRSHHDIERDQ 316

  Fly   329 VRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLFKQT 393
            .:.:|||::.|:.|..|.:.|||:|||.:..|||.|::|||.|.:||||::|:.|||.:|:|||:
pombe   317 AKHVKKALRFYEGLTKRVSANGHAVDILAGCLDQIGIMEMKSLASSTGGYLVLSDSFTTSIFKQS 381

  Fly   394 FQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWKLCT 458
            |||:|.||..|::.:.||||:||..::||||||.||..||||.||.:|.|:|||:|||..||:|.
pombe   382 FQRIFGRDSLNNMLLGFNATMEVLTTKELKISGLIGHAVSLNKKSQNVGDIEIGLGNTNSWKMCG 446

  Fly   459 LNPSSTVAYFFEVVNQHAAPIPQG-GRGCIQFITQYQHPSGQRRIRVTTLARNWADATSNVHHIS 522
            ::|.||.|.:|||..| :|..||| .||.:|::|.|||.|...|:||||:||.:||..|.:  |.
pombe   447 ISPKSTYAIYFEVATQ-SASAPQGDSRGLVQYLTLYQHSSNTFRLRVTTVARAFADGGSPL--IV 508

  Fly   523 AGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNFSLFPQ 587
            ..||||||||.|||:..::||.|:|||:|||.||.||:|||||.||.||||:|||||..|:|:||
pombe   509 NSFDQEAAAVAMARIAAFKAEVDDGPDVLRWTDRMLIKLCQKFAEYRKDDPSSFRLSSQFTLYPQ 573

  Fly   588 FMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGP-PEPVLLDTASIQ 651
            |||:||||.||||||||||||.||||||..||:..|||||||.|.|:||..| ..|||||..|::
pombe   574 FMYYLRRSPFLQVFNNSPDETAFYRHMLNHEDVNNSLIMIQPTLQSFSFEHPGGVPVLLDAVSVK 638

  Fly   652 ADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPRYIDT 716
            .|.|||:||||.|||:||:||||||...||:.|||:|.|:||:||..:|.|:|..|||:||:|..
pombe   639 PDVILLLDTFFHILIFHGDTIAQWRNAGYQNQPEYQNLKELLEAPRVEAAELLIDRFPIPRFIVC 703

  Fly   717 EHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLKKLAVSTT 780
            :.||||||||||::|||:|||....||..|        ...:||||||||.||.|||||||:.:
pombe   704 DQGGSQARFLLSRLNPSETHNTTSMYGAPP--------AHAILTDDVSLQTFMSHLKKLAVAVS 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	445/768 (58%)
		zf-Sec23_Sec24	58..97	CDD:282641	21/38 (55%)
		Sec23-like	126..396	CDD:238755	143/269 (53%)
		Sec23_BS	409..512	CDD:285301	58/103 (56%)
		Sec23_helical	530..623	CDD:282646	66/92 (72%)
		Sec23_C	618..738	CDD:200443	74/120 (62%)
sec231	NP_587900.1	SEC23	1..759	CDD:227380	447/777 (58%)
		zf-Sec23_Sec24	53..91	CDD:282641	21/38 (55%)
		Sec23-like	120..384	CDD:238755	143/269 (53%)
		Sec23_BS	397..500	CDD:285301	58/103 (56%)
		Sec23_helical	526..609	CDD:282646	60/82 (73%)
		Sec23_C	604..725	CDD:200443	74/120 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	290	1.000	Domainoid score	I282
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4642
Inparanoid	1	1.050	886	1.000	Inparanoid score	I49
OMA	1	1.010	-	-		QHG53648
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm47255
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	LDO	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
TreeFam	1	0.960	-	-
	14	13.860