DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and Sec23a

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001348885.1	Gene:	Sec23a / 20334	MGIID:	1349635	Length:	765	Species:	Mus musculus

Alignment Length:	783	Identity:	573/783 - (73%)
Similarity:	664/783 - (84%)	Gaps:	24/783 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSN 65
            ||||.|||||||:|||||.:||||||||:||:|:|||:|.|:.||||||||||||||||||:|:.
Mouse     1 MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTT 65

  Fly    66 CRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPV 130
            |||:||||||||||||||.||||:|||.|||.||.|||.:|||||:|.||:|||.:.|.|.||.:
Mouse    66 CRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISELNQPAELLPQFSSIEYVVLRGPQMPLI 130

  Fly   131 FIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDL 195
            |:::||||:::|:|.|||:|:||||||||..|||||||||:|:||||||.||.||||||||||||
Mouse   131 FLYVVDTCIEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDL 195

  Fly   196 TAKQVQDMLGIGR----GAAPGPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQ 256
            :|||:|:|||:.:    .|..|||.||            .||::|||||:.:.|..|.|||.|||
Mouse   196 SAKQLQEMLGLSKVPVTQATRGPQVQQ------------PPPSNRFLQPVQKIDMNLTDLLGELQ 248

  Fly   257 RDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSH 321
            |||||||||||.|||:|.||||||||||||:||||.|||.|:|||.:||||.||.||||.||||.
Mouse   249 RDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSW 313

  Fly   322 HDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFN 386
            |||.|||.:::||..||::|||.||||.||.:|||:||||||||||||...|.|||:||||||||
Mouse   314 HDIEKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFN 378

  Fly   387 SSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNT 451
            :|||||||||||.:|.....||.|..|||:|.|||:||||.||.|||||.|.|.||:.|||.|.|
Mouse   379 TSLFKQTFQRVFTKDIHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGT 443

  Fly   452 VQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATS 516
            .|||:|.|:|::|:|.:|||||||.|||||||||.:||:|||||.||||||||||:|||||||.:
Mouse   444 CQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSSGQRRIRVTTIARNWADAQT 508

  Fly   517 NVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQN 581
            .:.:|:|.|||||||:||||:.:|||||:||||:|||:||||||||||||||.||||||||.|:.
Mouse   509 QIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPNSFRFSET 573

  Fly   582 FSLFPQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLD 646
            |||:||||:|||||.|||||||||||:::|||..||:||||||||||||||:|||:|||||||||
Mouse   574 FSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLD 638

  Fly   647 TASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMP 711
            ::||.|||||||||||||||||||||||||...||||||||||:.|||||||||||||.:|||||
Mouse   639 SSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMP 703

  Fly   712 RYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLKKLA 776
            ||||||||||||||||||||||||||||||:||        :.|||:||||||||:||:||||||
Mouse   704 RYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQ--------ESGAPILTDDVSLQVFMDHLKKLA 760

  Fly   777 VST 779
            ||:
Mouse   761 VSS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	562/770 (73%)
		zf-Sec23_Sec24	58..97	CDD:282641	31/38 (82%)
		Sec23-like	126..396	CDD:238755	184/273 (67%)
		Sec23_BS	409..512	CDD:285301	72/102 (71%)
		Sec23_helical	530..623	CDD:282646	72/92 (78%)
		Sec23_C	618..738	CDD:200443	106/119 (89%)
Sec23a	NP_001348885.1	PLN00162	12..763	CDD:215083	562/770 (73%)
Sec23a	NP_001348885.1	Gelsolin-like. /evidence=ECO:0000255	632..718		75/85 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842293
Domainoid	1	1.000	376	1.000	Domainoid score	I860
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4642
Inparanoid	1	1.050	1189	1.000	Inparanoid score	I193
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm43401
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	LDO	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800