DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and sec-23

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_507877.1	Gene:	sec-23 / 180317	WormBaseID:	WBGene00004754	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	835	Identity:	486/835 - (58%)
Similarity:	611/835 - (73%)	Gaps:	68/835 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDL----PPIQYEPVLC 61
            |.|:||::...:..|||:.|||:||.||:::.:|||||.|.:.||||||..    ||::|:||||
Worm     1 MATWEEYLGAQQANDGVQFTWNMWPHSRVDSQKLVVPLTCFFTPLKERPSTEVAQPPLEYDPVLC 65

  Fly    62 TRSNCRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPT 126
            .:::|:|||||||.||||||:|:|.||..|||||..||||:|.::|.||.|.|:|||||:.:|.|
Worm    66 QKASCKAILNPLCAVDYRAKIWMCPFCNNRNPFPAHYAAIAEDNRPPELYPQFTTIEYTLRKATT 130

  Fly   127 MPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRG 191
            |||:|:|:|||||..|||.:||:.||.:|||||.:|||||||:|:|:|:|||..:|.|:||||:|
Worm   131 MPPIFVFVVDTCMTAEELKSLKECLQTALSLLPADALVGLITYGRMVQLHELNTQGISRSYVFKG 195

  Fly   192 TKDLTAKQVQDM-------------------------LGIGRGAAP-----------------GP 214
            ||::||||::|:                         :.:|.||||                 ||
Worm   196 TKEVTAKQIKDVMAGGGLSQRPAAGAPGAPAGAPGAPMAMGSGAAPLGQLPGSGLPGGLPRGGGP 260

  Fly   215 QQQQHLPGQ-----PAGAAAPVP--PAHRFLQPIGQCDAALGDLLSELQRDPWPVPQGKRYLRST 272
            .    |||.     ..|..||||  ||::|||||.:||.::.||:.::..|.||||||.|.||:|
Worm   261 P----LPGAAQGIVAPGGGAPVPHAPANKFLQPISECDESINDLIDQISIDRWPVPQGHRPLRAT 321

  Fly   273 GAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHHDIHKDNVRFMKKAIK 337
            ||||::||.|||..:|:||.|||:|:||.|:.|||.||.:|||:||||.:.|.:|...:||||||
Worm   322 GAALAVAVTLLESCFPSTGARIMSFIGGACTHGPGAVVGEELKNPIRSWNSIKEDAAPYMKKAIK 386

  Fly   338 HYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLFKQTFQRVFARDG 402
            .||.||.|...|||:||:||||||||||||||.:.||:|||:||||||||||||||:||.|.:|.
Worm   387 FYDGLAARIVKNGHAVDVYSCALDQTGLLEMKNMFNSSGGHVVMGDSFNSSLFKQTYQRSFDKDS 451

  Fly   403 RNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWKLCTLNPSSTVAY 467
            ..:|||.||||:|||....|||.|.:|.|.|.||::.:|||.|:|:|.|.|||...::|.:|:..
Worm   452 AGNLKMGFNATMEVKVGAGLKIEGVLGCCASGNVRNANVSDQEMGIGGTCQWKFGAISPRTTIGV 516

  Fly   468 FFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATSNVHHISAGFDQEAAAV 532
            .||:..||.:.|||||||.:||:|||||..|::||||||..|.|||..:...:|:.|||||||||
Worm   517 VFEIAAQHGSAIPQGGRGMVQFVTQYQHADGRKRIRVTTTCRTWADMATQQPNIAYGFDQEAAAV 581

  Fly   533 LMARMVVYRAETD-EGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNFSLFPQFMYHLRRSQ 596
            .:||:..:||..: :.|:.|||:||.||||||||||||||||||||||..||||||||:||||||
Worm   582 AIARLASFRASNENDTPEALRWLDRSLIRLCQKFGEYSKDDPNSFRLSDKFSLFPQFMFHLRRSQ 646

  Fly   597 FLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLDTASIQADRILLMDTF 661
            ||||||||||||.:|||:|..|::.:|..||||:|:|||||||||||||||:||.||||||||.:
Worm   647 FLQVFNNSPDETAYYRHILFSENVLESTTMIQPVLFSYSFNGPPEPVLLDTSSILADRILLMDDY 711

  Fly   662 FQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPRYIDTEHGGSQARFL 726
            |.:|||||:||||||...:.:.|:|..|||||:|||.||..|||.||||||||.|||.|||||||
Worm   712 FHVLIYHGQTIAQWRKQNFHENPQYATFKQLLEAPVADATSILQERFPMPRYIVTEHEGSQARFL 776

  Fly   727 LSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLKKLAVSTTT 781
            |||||||.||||.||.          :.|:.|.|||||||:||||||||:.|::|
Worm   777 LSKVNPSLTHNNPYAN----------EAGSAVFTDDVSLQVFMEHLKKLSSSSST 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	480/820 (59%)
		zf-Sec23_Sec24	58..97	CDD:282641	27/38 (71%)
		Sec23-like	126..396	CDD:238755	169/318 (53%)
		Sec23_BS	409..512	CDD:285301	54/102 (53%)
		Sec23_helical	530..623	CDD:282646	66/93 (71%)
		Sec23_C	618..738	CDD:200443	86/119 (72%)
sec-23	NP_507877.1	PLN00162	12..811	CDD:215083	474/812 (58%)
		zf-Sec23_Sec24	62..101	CDD:282641	27/38 (71%)
		Sec23-like	130..445	CDD:238755	169/318 (53%)
		Sec23_BS	458..561	CDD:285301	54/102 (53%)
		Sec23_helical	590..673	CDD:282646	61/82 (74%)
		Sec23_C	668..788	CDD:200443	86/119 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162419
Domainoid	1	1.000	329	1.000	Domainoid score	I620
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4642
Inparanoid	1	1.050	985	1.000	Inparanoid score	I148
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		oto19452
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	LDO	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840