DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and SEC23A

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_005267319.1	Gene:	SEC23A / 10484	HGNCID:	10701	Length:	789	Species:	Homo sapiens

Alignment Length:	807	Identity:	574/807 - (71%)
Similarity:	664/807 - (82%)	Gaps:	48/807 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSN 65
            ||||.|||||||:|||||.:||||||||:||:|:|||:|.|:.||||||||||||||||||:|:.
Human     1 MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTT 65

  Fly    66 CRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPV 130
            |||:||||||||||||||.||||:|||.|||.||.|||.:|||||:|.||:|||.:.|.|.||.:
Human    66 CRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGISELNQPAELLPQFSSIEYVVLRGPQMPLI 130

  Fly   131 FIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDL 195
            |:::|||||::|:|.|||:|:||||||||..|||||||||:|:||||||.||.||||||||||||
Human   131 FLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDL 195

  Fly   196 TAKQVQDMLGIGR----GAAPGPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQ 256
            :|||:|:|||:.:    .|..|||.||            .||::|||||:.:.|..|.|||.|||
Human   196 SAKQLQEMLGLSKVPLTQATRGPQVQQ------------PPPSNRFLQPVQKIDMNLTDLLGELQ 248

  Fly   257 RDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSH 321
            |||||||||||.|||:|.||||||||||||:||||.|||.|:|||.:||||.||.||||.||||.
Human   249 RDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSW 313

  Fly   322 HDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFN 386
            |||.|||.:::||..||::|||.||||.||.:|||:||||||||||||...|.|||:||||||||
Human   314 HDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFN 378

  Fly   387 SSLFKQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNT 451
            :|||||||||||.:|.....||.|..|||:|.|||:||||.||.|||||.|.|.||:.|||.|.|
Human   379 TSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGT 443

  Fly   452 VQWKLCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATS 516
            .|||:|.|:|::|:|.:|||||||.|||||||||.|||:|||||.||||||||||:|||||||.:
Human   444 CQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQT 508

  Fly   517 NVHHISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQN 581
            .:.:|:|.|||||||:||||:.:|||||:||||:|||:||||||||||||||.||||:|||.|:.
Human   509 QIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSET 573

  Fly   582 FSLFPQ------------------------FMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQ 622
            |||:||                        ||:|||||.|||||||||||:::|||..||:||||
Human   574 FSLYPQRRDFPKTSGEILENQEKARSACLKFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQ 638

  Fly   623 SLIMIQPILYSYSFNGPPEPVLLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYE 687
            ||||||||||:|||:|||||||||::||.|||||||||||||||||||||||||...||||||||
Human   639 SLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYE 703

  Fly   688 NFKQLLQAPVDDAQEILQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTV 752
            ||:.|||||||||||||.:|||||||||||||||||||||||||||||||||||:||
Human   704 NFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQ-------- 760

  Fly   753 DGGAPVLTDDVSLQLFMEHLKKLAVST 779
            :.|||:||||||||:||:||||||||:
Human   761 ESGAPILTDDVSLQVFMDHLKKLAVSS 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	563/794 (71%)
		zf-Sec23_Sec24	58..97	CDD:282641	31/38 (82%)
		Sec23-like	126..396	CDD:238755	185/273 (68%)
		Sec23_BS	409..512	CDD:285301	73/102 (72%)
		Sec23_helical	530..623	CDD:282646	71/116 (61%)
		Sec23_C	618..738	CDD:200443	106/119 (89%)
SEC23A	XP_005267319.1	PLN00162	12..787	CDD:215083	563/794 (71%)
		zf-Sec23_Sec24	58..97	CDD:282641	31/38 (82%)
		Sec23-like	126..388	CDD:238755	185/273 (68%)
		Sec23_BS	401..504	CDD:285301	73/102 (72%)
		Sec23_helical	522..639	CDD:282646	71/116 (61%)
		Sec23_C	634..754	CDD:200443	106/119 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152224
Domainoid	1	1.000	377	1.000	Domainoid score	I865
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4642
Inparanoid	1	1.050	1188	1.000	Inparanoid score	I194
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm41343
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	LDO	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800