DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec23 and SEC23B

DIOPT Version :9

Sequence 1:	NP_001246932.1	Gene:	Sec23 / 40694	FlyBaseID:	FBgn0262125	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001166216.1	Gene:	SEC23B / 10483	HGNCID:	10702	Length:	767	Species:	Homo sapiens

Alignment Length:	779	Identity:	571/779 - (73%)
Similarity:	652/779 - (83%)	Gaps:	14/779 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTYEEFIQQNEDRDGVRLTWNVWPSSRIEASRLVVPLACLYQPLKERPDLPPIQYEPVLCTRSN 65
            |.||.|||||||:|||||.:||||||||:||:|:|||||||..||||||||||:|||||||:|..
Human     1 MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPT 65

  Fly    66 CRAILNPLCQVDYRAKLWVCNFCFQRNPFPPQYAAISEQHQPAELIPGFSTIEYTITRAPTMPPV 130
            |:|:||||||||||||||.||||||||.|||.|..|||.:|||||:|.||||||.|.|....|.:
Human    66 CKAVLNPLCQVDYRAKLWACNFCFQRNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLI 130

  Fly   131 FIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDL 195
            |:::||||::|::|.|||:||||||||||.:|||||||||:|:|||||..||.||||||||||||
Human   131 FLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDL 195

  Fly   196 TAKQVQDMLGIGRGAAPGPQQQQHLPGQPAGAAAPVPPAHRFLQPIGQCDAALGDLLSELQRDPW 260
            ||||:|||||:.:.|.|   .||..|.||  ...|. .:.|||||:.:.|..|.|||.|||||||
Human   196 TAKQIQDMLGLTKPAMP---MQQARPAQP--QEHPF-ASSRFLQPVHKIDMNLTDLLGELQRDPW 254

  Fly   261 PVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRSHHDIH 325
            ||.||||.|||||.||||||||||.|:||||.|||.|.|||.:||||.||.||||.||||.|||.
Human   255 PVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIE 319

  Fly   326 KDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLF 390
            |||.||||||.|||:.||.|.|.|||.:|||:||||||||||||...|.|||:||||||||:|||
Human   320 KDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLTGGYMVMGDSFNTSLF 384

  Fly   391 KQTFQRVFARDGRNDLKMAFNATLEVKCSRELKISGGIGSCVSLNVKSPSVSDVEIGMGNTVQWK 455
            ||||||:|.:|...|.:|||.|||:||.||||||:|.||.|||||||.|.||:.|:|:|.|.|||
Human   385 KQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWK 449

  Fly   456 LCTLNPSSTVAYFFEVVNQHAAPIPQGGRGCIQFITQYQHPSGQRRIRVTTLARNWADATSNVHH 520
            :|.|:|:||:..:|||||||..||||||||.|||:|.|||.|.||||||||:||||||..|.:.|
Human   450 ICGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQFVTHYQHSSTQRRIRVTTIARNWADVQSQLRH 514

  Fly   521 ISAGFDQEAAAVLMARMVVYRAETDEGPDILRWVDRQLIRLCQKFGEYSKDDPNSFRLSQNFSLF 585
            |.|.||||||||||||:.|:|||::||||:|||:||||||||||||:|:|:||.|||||.:|||:
Human   515 IEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLY 579

  Fly   586 PQFMYHLRRSQFLQVFNNSPDETTFYRHMLMREDLTQSLIMIQPILYSYSFNGPPEPVLLDTASI 650
            ||||:|||||.|||||||||||:::|||...|:||||||||||||||||||:|||||||||::||
Human   580 PQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSI 644

  Fly   651 QADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAPVDDAQEILQTRFPMPRYID 715
            .|||||||||||||:||.||||||||...|||||||||||.|||||:||||||||.||||||||:
Human   645 LADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFPMPRYIN 709

  Fly   716 TEHGGSQARFLLSKVNPSQTHNNMYAYGQAPIGQVTVDGGAPVLTDDVSLQLFMEHLKKLAVST 779
            |||||||||||||||||||||||:||:||        :.|||:||||||||:||:||||||||:
Human   710 TEHGGSQARFLLSKVNPSQTHNNLYAWGQ--------ETGAPILTDDVSLQVFMDHLKKLAVSS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec23	NP_001246932.1	PLN00162	12..779	CDD:215083	561/766 (73%)
		zf-Sec23_Sec24	58..97	CDD:282641	31/38 (82%)
		Sec23-like	126..396	CDD:238755	187/269 (70%)
		Sec23_BS	409..512	CDD:285301	72/102 (71%)
		Sec23_helical	530..623	CDD:282646	69/92 (75%)
		Sec23_C	618..738	CDD:200443	105/119 (88%)
SEC23B	NP_001166216.1	PLN00162	12..765	CDD:215083	561/766 (73%)
SEC23B	NP_001166216.1	Gelsolin-like. /evidence=ECO:0000255	634..720		73/85 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152225
Domainoid	1	1.000	377	1.000	Domainoid score	I865
eggNOG	1	0.900	-	-		E1_COG5047
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1188	1.000	Inparanoid score	I194
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53648
OrthoDB	1	1.010	-	-		D155701at33208
OrthoFinder	1	1.000	-	-		FOG0001309
OrthoInspector	1	1.000	-	-		otm41343
orthoMCL	1	0.900	-	-		OOG6_100992
Panther	1	1.100	-	-	O	PTHR11141
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1288
SonicParanoid	1	1.000	-	-		X910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800