Protein Alignment MTA1-like and MTA2

DIOPT Version :10

• Sequence 1: NP_001262293.1
• Gene: MTA1-like / 40693
• FlyBaseID: FBgn0027951
• Length: 922
• Species: Drosophila melanogaster
• Sequence 2: NP_004730.2
• Gene: MTA2 / 9219
• HGNCID: 7411
• Length: 668
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 353/911 - (38%)
• Similarity: 462/911 - (50%)
• Gaps: 275/911 - (30%)

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::|||:||||||||...|||||||:|.:||||:.:.|..|||.:...
Human     1 MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNARE 65

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
            ..|:|
Human    66 FEEES------------------------------------------------------------ 70

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                     |...::.:||:|:||||||||||.||:|||.|||||||||
Human    71 -------------------------KQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTL 110

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            ||||:.|..||.|:|.|||.|||||.|||||||:||||||.:||.:||.:|.:..:|:|..:::|
Human   111 LNETDILSQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKME 175

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|::.||||:|||||||:|::||||||||||||::|||||||||||||||||||||:.|.:
Human   176 MKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQR 240

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            :.|.:.::||:|||..||||||||:|:||||||.||||||||||||||||||||||||:|..|::
Human   241 NGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQ 305

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQY---NNN-----GKGNGTSTKAGGGIYNGTTN 447
            :||||||||||:||||:||.||:.||||||||.|   |.|     |...|.:   |.|...|.|
Human   306 FYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMN---GAGFQKGLT- 366

  Fly   448 GSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKK 512
                       ||||.||:|:||.:....:...|||.|||.||::||.:|
Human   367 -----------CESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLK--------------- 405

  Fly   513 SSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQA- 576
                  ||| .|.| ||..|.                            |...:.||:|..||:
Human   406 ------TPT-QLEG-ATRGTT----------------------------EPHSRGHLSRPEAQSL 434

  Fly   577 HGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRI 641
            .....|:...:.:.|.|..|.|.|..:||:||.:||.:::|::|||:....|||..:|.|.:.|:
Human   435 SPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRL 499

  Fly   642 SGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVV-----SFPKPP 701
            ...::..:|                                :.|..::||..:|     ..|..|
Human   500 PKAAKTPLK--------------------------------IHPLVRLPLATIVKDLVAQAPLKP 532

  Fly   702 KAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIR-------KRAHEDQQLNGTEVTIVP 759
            |.|.|:        |:|             |.....|..|       |||:|         |:..
Human   533 KTPRGT--------KTP-------------INRNQLSQNRGLGGIMVKRAYE---------TMAG 567

  Fly   760 SGPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAP 824
            :|.|                      .:|:|:||:    :|.:..:|.|    .::|.::..|||
Human   568 AGVP----------------------FSANGRPLA----SGIRSSSQPA----AKRQKLNPADAP 602

  Fly   825 DDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPA--APEPSSRPIESQIVILDXPS-PAS 886
            :.|.|.|....:..||.|:.:::|||||:|...|.:||.  |..|.        |.|. || |||
Human   603 NPVVFVATKDTRALRKALTHLEMRRAARRPNLPLKVKPTLIAVRPP--------VPLPAPSHPAS 659

  Fly   887 T 887
            |
Human   660 T 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	103/249 (41%)
		ELM2	232..284	CDD:460214	26/51 (51%)
		SANT_MTA3_like	352..397	CDD:212559	36/44 (82%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
		MTA_R1	589..670	CDD:465388	22/80 (28%)
MTA2	NP_004730.2	BAH_MTA	3..168	CDD:240060	103/249 (41%)
		ELM2	147..198	CDD:460214	26/50 (52%)
		SANT_MTA3_like	267..312	CDD:212559	36/44 (82%)
		ZnF_GATA	363..414	CDD:214648	27/85 (32%)
		PHA03247	<405..664	CDD:223021	95/407 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..437		11/56 (20%)
		MTA_R1	449..524	CDD:465388	26/106 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	580..599		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	647..668		9/22 (41%)