DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and MTA1

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_016877241.1	Gene:	MTA1 / 9112	HGNCID:	7410	Length:	799	Species:	Homo sapiens

Alignment Length:	928	Identity:	380/928 - (40%)
Similarity:	488/928 - (52%)	Gaps:	252/928 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAEDSPLAT 74
            ||||.|.:.::||||||||||||...|||||||:|||||||:.:.|:.|||||
Human    66 DYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSTLIALADKH------------ 118

  Fly    75 KLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNNSSSTA 139
                                     |.|                                  |..
Human   119 -------------------------ATL----------------------------------SVC 124

  Fly   140 IGGGAGGSGGAGGDAEKGEA------LTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNE 198
            ...|.|...|..|:.|:...      |..|.::|::|||||||||:||:|||.||||||||||||
Human   125 YKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNE 189

  Fly   199 TESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLV 263
            ||||:|||.::|.|||.||:||.||||||||||||||:|||.||...||:...|.|....||:.|
Human   190 TESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQV 254

  Fly   264 WTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEY 328
            |...:.|||::|||||||:||:|||||||||||||:|||||||||||||||||||||:.|||:.|
Human   255 WEAHNPLTDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIY 319

  Fly   329 SIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYYY 393
            .|.:::|:|||..||||||||:|:||||||||||||||||||||.||:|||||||:|..||||||
Human   320 DISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYY 384

  Fly   394 MWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSN-GK 457
            |||||||||||||:||.|||.||||||||.||.......:......|:.|||  |:...|.. |:
Human   385 MWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGT--GAPGQSPGAGR 447

  Fly   458 PCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAASTPTA 522
            .||||.||:|.||.|....:...|||.|||.||::||.:|..|:.| ||.....:|:.:
Human   448 ACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLD-GERPGPNRSNMS------ 505

  Fly   523 TLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGI-AISSGSP 586
                                                                 .||: |.|||||
Human   506 -----------------------------------------------------PHGLPARSSGSP 517

  Fly   587 RPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAEIKK 651
            :..||||.||||||..:||:||.:||.|::|..|||.....||:..:|.|.|.|:...||:.
Human   518 KFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKAECTARLPEASQSP--- 579

  Fly   652 LLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSF----PKPPKAPDGSLVYDR 712
                                         |||....:.||.||:.:    |:||| ||
Human   580 -----------------------------LVLKQAVRKPLEAVLRYLETHPRPPK-PD------- 607

  Fly   713 VPNKSPDVV---AVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIVPSGPPAKRPNKDPMPS 774
             |.||...|   ..|| |...:|...:.:.:.||::|  |.||.:      |...||.   .|||
Human   608 -PVKSVSSVLSSLTPA-KVAPVINNGSPTILGKRSYE--QHNGVD------GNMKKRL---LMPS 659

  Fly   775 HCPSPEQFAAMMAASGQPLSRHH-------LNGKQ---KIAQMARGGN---GRKQVISWMDAPDD 826
            .       ...:..:....:||.       ||||.   |: ::.|||:   .:::.::|:|||||
Human   660 R-------GTYLGLANHGQARHMGPSRNLLLNGKSYPTKV-RLIRGGSLPPVKRRRMNWIDAPDD 716

  Fly   827 VYFRAND------------------------THKKTRKILSAVDLRRAARKPWRTLPIK-----P 862
            |::.|.:                        .|:|.||:||:.:.:||||:|::.:.::     |
Human   717 VFYMATEETRWGLPRAGGRAPHSVPALTTTSAHRKIRKLLSSSETKRAARRPYKPIALRQSQALP 781

  Fly   863 AAPEPSSRPIESQIVILD 880
            ..|.|.: |:..:.::::
Human   782 PRPPPPA-PVNDEPIVIE 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	110/248 (44%)
		ELM2	232..284	CDD:279754	27/51 (53%)
		SANT_MTA3_like	352..397	CDD:212559	38/44 (86%)
		SANT	353..398	CDD:197842	39/44 (89%)
		ZnF_GATA	458..508	CDD:238123	25/49 (51%)
MTA1	XP_016877241.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147984
Domainoid	1	1.000	110	1.000	Domainoid score	I6301
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3442
Inparanoid	1	1.050	633	1.000	Inparanoid score	I843
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm41058
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	LDO	PTHR10865
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.760