DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and mta1

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_005158917.1	Gene:	mta1 / 794477	ZFINID:	ZDB-GENE-131121-353	Length:	617	Species:	Danio rerio

Alignment Length:	809	Identity:	330/809 - (40%)
Similarity:	425/809 - (52%)	Gaps:	223/809 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::|.||||||||||...|||||||:|||||||:...|:.|||||
Zfish     1 MAANMYRVGDYVYFENSSSNPLLIRRIEELNKTANGNVEAKVVCFYRRRDISATLIALADKH--- 62

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
                                             ...::||..:|....
Zfish    63 ---------------------------------AREMEEEMENPEMVD----------------- 77

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                         |..||::|::|||||||||:||:|||.|||||.|||
Zfish    78 -----------------------------LPEKQKHQLRHRELFLSRQLESLPATHIRGKCCVTL 113

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            |||||:|:|||:::|.|||.||:||.||||||||||||||::||.||...||:...|||:||:||
Zfish   114 LNETEALKSYLDREDAFFYSLVYDPQQKTLLADKGEIRVGNKYQADITDLLKEGEEDDRELEKLE 178

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|.:.||:::|||||||:||:|||||||||||||:|||||||||||||||||||||:.|||
Zfish   179 EKVWDPSNPLTEKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHK 243

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            :.|.:..::::|||..||||||||:|:||||||||||||||||||||.||:|||||||:|..|||
Zfish   244 NGYDMTRAIAALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIE 308

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYN--NNGKGNGTSTKA----GGGIYNGTTNGS 449
            ||||||||||||||||:||.|||.||||||||.||  |..:.:..|.|.    |.|...|.....
Zfish   309 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQLSVNSVKPGLVNGAGALPGAPGQP 373

  Fly   450 TDLSSNGKPCESC--GTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKK 512
            ..|   |:.||||  .:|.|.||.|....:...|||.|||.||::||.:|..|:.| ||.....:
Zfish   374 VGL---GRACESCYSESTSSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLD-GERPGPNR 434

  Fly   513 SSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAH 577
            ::.:                                                           .|
Zfish   435 NNMS-----------------------------------------------------------PH 440

  Fly   578 GIAI-SSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRI 641
            |:.: .||||:..:|||.||||||:.||:.||.:|:.:::.|..||.....:|.:.:|.|...|:
Zfish   441 GLPVRHSGSPKFAVKTRQAFYLHTSQMTKAARRVCQDLLRSKYLARHPYTPVNTIAIKAECAVRL 505

  Fly   642 --SGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSF----PKP 700
              ..|..|.:|:.:                                  :.||.:||.:    |.|
Zfish   506 PDMSKKPASLKQTV----------------------------------RKPLESVVRYLEAHPLP 536

  Fly   701 PKA--PDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQ-LNGTEVTIVPSGP 762
            |||  |.|..:         ...::...|...|:...:.:.:.||.:|... |:|::..::
Zfish   537 PKADPPRGVTI---------STGSLTPIKSTPILNNGSPTILGKRNYEQHNGLDGSKPKVL---- 588

  Fly   763 PAKRPNKDPMPSHCPSPEQFAAMMAASGQ 791
                         .|..|..|..|:.:|:
Zfish   589 -------------APQWEIMAKRMSEAGR 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	108/249 (43%)
		ELM2	232..284	CDD:279754	29/51 (57%)
		SANT_MTA3_like	352..397	CDD:212559	38/44 (86%)
		SANT	353..398	CDD:197842	39/44 (89%)
		ZnF_GATA	458..508	CDD:238123	24/51 (47%)
mta1	XP_005158917.1	BAH_MTA	3..171	CDD:240060	108/249 (43%)
		ELM2	150..202	CDD:279754	29/51 (57%)
		SANT	269..316	CDD:197842	40/46 (87%)
		SANT_MTA3_like	270..315	CDD:212559	38/44 (86%)
		ZnF_GATA	375..430	CDD:214648	26/58 (45%)
		ZnF_GATA	379..437	CDD:238123	24/58 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581883
Domainoid	1	1.000	110	1.000	Domainoid score	I6257
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3442
Inparanoid	1	1.050	617	1.000	Inparanoid score	I863
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm26314
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	LDO	PTHR10865
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.760