DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and MTA3

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_001317371.1	Gene:	MTA3 / 57504	HGNCID:	23784	Length:	594	Species:	Homo sapiens

Alignment Length:	763	Identity:	327/763 - (42%)
Similarity:	426/763 - (55%)	Gaps:	186/763 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::||||||||||||..:|||||||:|||||||:.|.|:.|||||...
Human     1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKE 65

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
            ..|:|           .|.|..:
Human    66 IEEES-----------ETTVEAD------------------------------------------ 77

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                         ||.||::|:||||||||||.||:|||.|||||||.|
Human    78 -----------------------------LTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVAL 113

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            ||||||:.|||:|:|||||.||:||:.|||||||||||||.|||.|||..|.:..:|:|:..:||
Human   114 LNETESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSKLE 178

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|...||||:|||||||:|::|||||||||||||:|||||||||||||||||||||:.|::
Human   179 VKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYR 243

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            |.|.:..::|.|||..||||||||:|:||||||:||||||||||||||||||||||||:|..|||
Human   244 HSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIE 308

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSN 455
            ||||||||||||||||:||.|||.||||||||.|:.......:::....|..||.. |:|....|
Human   309 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAV-GTTFQPQN 372

  Fly   456 ---GKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAA 517
               |:.||||..|:|.||.|....:...|||..||.||::||.:|..|:.:..:
Human   373 PLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEK----------- 426

  Fly   518 STPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAI- 581
                     |:.:||     .:|.::                      ::|::|...|  |:.:
Human   427 ---------LSPSPT-----TEDPRV----------------------RSHVSRQAMQ--GMPVR 453

  Fly   582 SSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQ 646
            ::|||:..:|||.||:|||...|:.||.:|::.::.::|||:...|||...::.|:.:|     .
Human   454 NTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADR-----H 513

  Fly   647 AEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPK--PPKAPDGSLV 709
            ||:.                    |:|        :.:...:.||..::.:.:  |.|.|:
Human   514 AELS--------------------GSP--------LKSKSTRKPLACIIGYLEIHPAKKPN---- 546

  Fly   710 YDRVPNKSPDVVAVPADKELTIIPTQATSTI---RKRAHEDQQLNGTE 754
               |...:|. :..|..|.:...|...:.:|   |..:|.    ||.:
Human   547 ---VIRSTPS-LQTPTTKRMLTTPNHTSLSILGKRNYSHH----NGLD 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	115/249 (46%)
		ELM2	232..284	CDD:279754	29/51 (57%)
		SANT_MTA3_like	352..397	CDD:212559	39/44 (89%)
		SANT	353..398	CDD:197842	40/44 (91%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
MTA3	NP_001317371.1	BAH_MTA	3..170	CDD:240060	115/248 (46%)
		ELM2	150..201	CDD:396160	29/50 (58%)
		SANT_MTA3_like	270..315	CDD:212559	39/44 (89%)
		ZnF_GATA	376..425	CDD:214648	21/48 (44%)
		MTA_R1	461..537	CDD:407344	26/108 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147985
Domainoid	1	1.000	110	1.000	Domainoid score	I6301
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	633	1.000	Inparanoid score	I843
Isobase	1	0.950	-	0	Normalized mean entropy	S4979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm41058
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	O	PTHR10865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3578
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740