DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTA1-like and rerea

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_005162258.1	Gene:	rerea / 569081	ZFINID:	ZDB-GENE-060718-1	Length:	1531	Species:	Danio rerio

Alignment Length:	1024	Identity:	221/1024 - (21%)
Similarity:	355/1024 - (34%)	Gaps:	332/1024 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MYRVGDYVYVET-TPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAE 68
            :||.||.||:|: .||:||.|..|::...::..::...|..:||:.::|:.:.|    |
Zfish   103 VYRPGDCVYIESRRPNTPYFICSIQDFKLSKRDHLLMNVKWYYRQSEVPDSVYQ----H------ 157

  Fly    69 DSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNN 133
                                             |.::|                        :|.
Zfish   158 ---------------------------------LVQDR------------------------NNE 165

  Fly   134 NSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNE 198
            |.|...:                  .:|..   .:|.||||:|..|::..|..:||||:::..::
Zfish   166 NDSGREL------------------VITDP---VVKSRELFISDYVDTYHAAALRGKCNISHFSD 209

  Fly   199 TESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELESLV 263
            ..:.:.:..:.|:|||.|.::|..:.|.:.:||||||..:|..:|......:...:.:.|.|.||
Zfish   210 IFAAREFKARIDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPELQPFPSPGGQTVTENEELV 274

  Fly   264 WTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHKHEY 328
            |.|  .:.|..:..:|..:||:..||...|..|:      .....|||||.|..:|:|.||:..|
Zfish   275 WMP--GVNDCDLLMYLRAARSMAAFAGMCDGGST------EDGCLAASRDDTTLNALNTLHESSY 331

  Fly   329 SIEESMSSLVPSTGPVLCRDEIED-WSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIEYY 392
            ...:::..||....|.|    ||. ||..|...|.:.|.:|||:|..||::.||.|...::|.:|
Zfish   332 DAGKALQRLVKKPVPKL----IEKCWSEDEVKRFIKGLRQYGKNFFRIRKELLPNKETGELITFY 392

  Fly   393 YMWKTTD-----RYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDL 452
            |.||.|.     |..::.|.:.|...:|.:....|.       |..|........:.::....|.
Zfish   393 YYWKKTPEAASCRAHRRHRRQPVFRRIKTRTASTPV-------NTPSRPPSSEFLDLSSASEDDF 450

  Fly   453 SS-------NGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSM-------------- 496
            .|       .|..|..|.||.|..|:  ..|.....||..|..::::||.:
Zfish   451 DSEDSEQELKGYACRHCFTTTSKDWH--HGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMF 513

  Fly   497 ---KSATKGDAGEGDAK-KKSSSAAST-------PTATLAGLATTPTAVVDLNDDEKISDLTNRQ 550
               |....|.:|:...: :::..:.||       .||:..|.| :||     |:|.:.|..|:..
Zfish   514 KPVKEEDDGLSGKHSMRTRRNRGSMSTLRSGRKKQTASPDGRA-SPT-----NEDLRSSGRTSPS 572

  Fly   551 LHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIV 615
            ....|..: .|...:|                    :|..||:..   ..:||....|...:...
Zfish   573 AASTSSTD-SKTDSMK--------------------KPSKKTKEE---APSPMKSAKRQREKGAS 613

  Fly   616 KPKKAARQSAYAINAMLVKQEFTNRIS---------GKSQAE------IKKLLLLKPKDRGSVTK 665
            ..:::.|.||        |:..|..||         |:.:.|      :.......|||...
Zfish   614 DTEESERASA--------KKSKTQEISVPNSPSECEGEGEGESSDGRSVNDEGSSDPKDIDQ--- 667

  Fly   666 IANRLGAPG--------------------SGPHEWLV------LTPKDKMPLPAVVSFPKP---- 700
             .||..:|.                    .|.|..::      |.|   .|.||..:...|
Zfish   668 -DNRSSSPSIPSPRDNESDSDSSAQQQILQGQHPPVIQCQTGTLPP---APPPAAAASTTPTSGA 728

  Fly   701 --------PKAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTI 757
                    |..|..|:...::|...|          |::|    .|.:::.......|.|
Zfish   729 PSLSSQPSPSIPPTSMPPQQIPPAGP----------LSLI----QSGVQRLPSPHSPLQG----- 774

  Fly   758 VPSGPPAKR--------PNKDPM----------PSHCPSPEQFAAM---MAASGQPLSRHHLNGK 801
            :|..||..:        |...||          |||.|.|......   ||.|..|.|  .|:|:
Zfish   775 MPQPPPPSQTCPQALQPPLHGPMPPMGHPLQAGPSHMPHPHALPTQPFPMAQSQVPPS--PLSGQ 837

  Fly   802 QKIAQMARGGNGRKQVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIKPA-AP 865
            .:.|.           :|....|          |....:..|:   .::..:|.|..|:.|| .|
Zfish   838 AQAAS-----------LSQQQRP----------HTPPSQSQSS---SQSGSQPPREQPLPPAPLP 878

  Fly   866 EPSSRPIESQIVILDXPSPASTLTASAASATKLLSSSASRFEQQHPPFP 914
            .|..:|..:      .|.|.             :.::.|.....|||||
Zfish   879 MPHIKPPPT------TPIPQ-------------MPNAQSHKHPSHPPFP 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	52/248 (21%)
		ELM2	232..284	CDD:279754	14/51 (27%)
		SANT_MTA3_like	352..397	CDD:212559	18/45 (40%)
		SANT	353..398	CDD:197842	19/44 (43%)
		ZnF_GATA	458..508	CDD:238123	15/66 (23%)
rerea	XP_005162258.1	BAH_MTA	101..264	CDD:240060	52/248 (21%)
		ELM2	243..293	CDD:307553	14/51 (27%)
		SANT_MTA3_like	352..397	CDD:212559	18/44 (41%)
		ZnF_GATA	460..509	CDD:214648	13/50 (26%)
		Atrophin-1	525..1530	CDD:331285	94/493 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910