DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and Mta2

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_035972.3	Gene:	Mta2 / 23942	MGIID:	1346340	Length:	668	Species:	Mus musculus

Alignment Length:	912	Identity:	349/912 - (38%)
Similarity:	464/912 - (50%)	Gaps:	276/912 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::|||:||||||||...|||||||:|.:||||:.:.|..|||.:...
Mouse     1 MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNARE 65

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
            ..|:|
Mouse    66 FEEES------------------------------------------------------------ 70

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                     |...::.:||:|:||||||||||.||:|||.|||||||||
Mouse    71 -------------------------KQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTL 110

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            ||||:.|..||:|:|.|||.|||||.|||||||:||||||.::|.:||.:|.:..:|:|..:::|
Mouse   111 LNETDILNQYLDKEDCFFYSLVFDPVQKTLLADQGEIRVGCKFQAEIPDRLAEGESDNRNQQKME 175

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|::.||||:|||||||:|::||||||||||||::|||||||||||||||||||||:.|.:
Mouse   176 MKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQR 240

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            :.|.:.::||:|||..||||||||:|:||||||.||||||||||||||||||||||||:|..|::
Mouse   241 NGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQ 305

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQY---NNN-----GKGNGTSTKAGGGIYNGTTN 447
            :||||||||||:||||:||.||:.||||||||.|   |.|     |...|.:   |.|...|.|
Mouse   306 FYYMWKTTDRYIQQKRLKAAEADSKLKQVYIPTYTKPNPNQIISVGSKPGMN---GAGFQKGLT- 366

  Fly   448 GSTDLSSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKK 512
                       ||||.||:|:||.:....:...|||.|||.||::||.:|
Mouse   367 -----------CESCHTTQSAQWYAWGPPNMQCRLCASCWIYWKKYGGLK--------------- 405

  Fly   513 SSSAASTPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQA- 576
                  ||| .|.|.|...|                             |...:.||:|..||:
Mouse   406 ------TPT-QLEGAARGTT-----------------------------EPHSRGHLSRPEAQSL 434

  Fly   577 HGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRI 641
            .....|:...:.:.|.|..|.|.|..:||:||.:||.:::|::|||:....|||..:|.|.:.|:
Mouse   435 SPYTTSANRAKLLAKNRQTFLLQTTKLTRLARRMCRDLLQPRRAARRPYAPINANAIKAECSIRL 499

  Fly   642 SGKSQAEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVV-----SFPKPP 701
            ...::..:|                                :.|..::||..:|     ..|..|
Mouse   500 PKAAKTPLK--------------------------------IHPLVRLPLATIVKDLVAQAPLKP 532

  Fly   702 KAPDGSLVYDRVPNKSPDVVAVPADKELTIIPTQATST------IRKRAHEDQQLNGTEVTIVPS 760
            |.|.|:        |:|            |...|.|..      :.||::|         |:..:
Mouse   533 KTPRGT--------KTP------------INRNQLTQNRGLGGIMVKRSYE---------TMAGA 568

  Fly   761 GPPAKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHHLNGKQKIAQMARGGNGRKQVISWMDAPD 825
            |.|                      .:|:|:||:    :|.:..:|.|    .::|.::..|||:
Mouse   569 GVP----------------------FSANGRPLA----SGIRSSSQPA----AKRQKLNPADAPN 603

  Fly   826 DVYFRANDTHKKTRKILSAVDLRRAARKPWRTLPIK---------PAAPEP-SSRPIESQ--IVI 878
            .|.|.|....:..||.|:.:::|||||:|  .||:|         |..|.| ||.|..:.  ||:
Mouse   604 PVVFVATKDTRALRKALTHLEMRRAARRP--NLPLKVKPTLMTVRPPVPLPASSHPASTNEPIVL 666

  Fly   879 LD 880
            .|
Mouse   667 ED 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	102/249 (41%)
		ELM2	232..284	CDD:279754	25/51 (49%)
		SANT_MTA3_like	352..397	CDD:212559	36/44 (82%)
		SANT	353..398	CDD:197842	37/44 (84%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
Mta2	NP_035972.3	BAH_MTA	3..168	CDD:240060	102/249 (41%)
		ELM2	147..198	CDD:279754	25/50 (50%)
		SANT	266..313	CDD:197842	38/46 (83%)
		SANT_MTA3_like	267..312	CDD:212559	36/44 (82%)
		ZnF_GATA	363..413	CDD:214648	26/83 (31%)
		ZnF_GATA	366..421	CDD:238123	29/117 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..437		9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..599		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..668		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838074
Domainoid	1	1.000	61	1.000	Domainoid score	I10395
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I957
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm43128
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	O	PTHR10865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3578
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790