DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and egl-27

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_741012.1	Gene:	egl-27 / 174121	WormBaseID:	WBGene00001194	Length:	1129	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	149/826 - (18%)
Similarity:	287/826 - (34%)	Gaps:	266/826 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLATAED 69
            :||:.|.|:||.:.|.||:|..|......:..:|..|:..::|..|:|.
Worm    88 LYRLRDSVFVEVSQNEPYVIAAICGFKYTKRDHVVVKLTRYFRADDIPE---------------- 136

  Fly    70 SPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGTSNNN 134
              ::..|.|         ::.|:..::|.:..
Worm   137 --ISLNLMK---------QERAELEINPHLCP--------------------------------- 157

  Fly   135 SSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTLLNE- 198
                                            |..:||||.|....:.|.:.:||||.|..:.:
Worm   158 --------------------------------QSLNRELFNSELQITQPVSCLRGKCIVEYVKDV 190

  Fly   199 --TESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELES 261
              ..::..:...:||||:||.::.:...|.:....||||:.:|..:|...:.:..||...:|
Worm   191 RHARTVADFSLDNDTFFFCLHYNQDSTKLASTHYAIRVGTSFQATLPPMAECSVGDDSDRDE--- 252

  Fly   262 LVWTPEHSLTDRKIDQFLVVSRSIGTFA----RALDCSSSVKQPSLHMSAAAASRDITLFHAMNI 322
            |::.| :|:...:.:.::.::|...|:.    ..||...:.:  ||.:|      |:.:..|:..
Worm   253 LLYRP-NSIESGEEEDYIKLARCYRTYTLSGNHMLDSQKNAR--SLQVS------DLLMDEAIIQ 308

  Fly   323 LHKHEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQ 387
            ||:..|.|::::|.|  :...::...::::.:..:|..|.:.:::.||:|:.|.::.||..:.:|
Worm   309 LHRSGYKIDDALSEL--NANDIILTTDVDNMTQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQ 371

  Fly   388 IIEYYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGS-TD 451
            ::.|||:||.|....:.|:.........:|:   |..........|||:     |....:.| :|
Worm   372 LVSYYYLWKKTPEATKPKQAARRVNPTSIKR---PTKEKVKASRPTSTE-----YLDFDSASESD 428

  Fly   452 LSSN---GKPCESCGTTKSSQWNSVSSGHSTS-RLCLSCWEYWRRYGSMK--------------- 497
            :.:|   |:.|..|...:|..|:     |:.. .||..|..::::||.::
Worm   429 VENNGPSGRACHHCYGAESKDWH-----HANGLLLCTDCRLHYKKYGQLRQIANRPSQVPACLFK 488

  Fly   498 --------SATKGDAGEGDAKKKSSSAAS------TPTATLAG---LATTPTAVVDLNDDEKISD 545
                    |..:..||:.:.::::.|:.|      :|:....|   |....|....||...|.:
Worm   489 RSNSDEEESGVRTRAGKKEQRRRTPSSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSVKRA- 552

  Fly   546 LTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAISSGSPRPIMKTRTAFYLHTNPMTRVARAI 610
             ..|.||...|.|..|                    |:.|..|...|       |.|.|
Worm   553 -PKRPLHNGVINNVEK--------------------SNSSEEPASPT-------TPPPT------ 583

  Fly   611 CRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQAE--------IKKLLLLKP-------KDR 660
                                      .||.::.....|        |.|.:.::|       ::.
Worm   584 --------------------------LTNGLTNGHGPESSTPNGETISKRMKVEPSYDDDDDEEE 622

  Fly   661 GSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPKPPKAPD------GSLVYDRVPNKSPD 719
            |.:|                  :...|..|:|.:..|.|.....:      |::..:......|.
Worm   623 GKMT------------------IDEGDDDPMPVLNGFKKEESVEEIKLELNGTIKKENGVETDPT 669

  Fly   720 VVAVPADKELTIIPTQATSTIRKRAHEDQQLNG---TEVTIVPSGP 762
            ......:.|..:..|.|..::..|...:.:.|.   .:..:.|..|
Worm   670 TPTCSMEAENEVCETPAVVSVEIRDETNGETNSDLKDDENVEPDSP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	45/250 (18%)
		ELM2	232..284	CDD:279754	12/51 (24%)
		SANT_MTA3_like	352..397	CDD:212559	13/44 (30%)
		SANT	353..398	CDD:197842	14/44 (32%)
		ZnF_GATA	458..508	CDD:238123	13/73 (18%)
egl-27	NP_741012.1	BAH_MTA	86..247	CDD:240060	45/250 (18%)
		ELM2	226..274	CDD:279754	12/51 (24%)
		SANT	335..382	CDD:197842	14/46 (30%)
		SANT_MTA3_like	336..381	CDD:212559	13/44 (30%)
		ZnF_GATA	434..483	CDD:214648	11/53 (21%)
		ZnF_GATA	438..488	CDD:238123	10/54 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4979
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860