DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and Mta3

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_006523574.1	Gene:	Mta3 / 116871	MGIID:	2151172	Length:	637	Species:	Mus musculus

Alignment Length:	768	Identity:	331/768 - (43%)
Similarity:	429/768 - (55%)	Gaps:	182/768 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::||||||||||||..:|||||||:|||||||:.|.|:.|||||...
Mouse     1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKE 65

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
            |.|:|           .|||..:
Mouse    66 TEEES-----------ETPVEAD------------------------------------------ 77

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                         ||.||::|:||||||||||.||:|||.|||||||.|
Mouse    78 -----------------------------LTEKQKHQLKHRELFLSRQYESLPATHIRGKCSVAL 113

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            ||||||:.|||:|:|||||.||:||:.|||||||||||||.:||.|||..|.:..:|:|:..:||
Mouse   114 LNETESVLSYLDKEDTFFYSLVYDPSVKTLLADKGEIRVGPKYQADIPDMLPEGDSDEREQSKLE 178

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|...||||:|||||||:|::|||||||||||||:|||||||||||||||||||||:.|::
Mouse   179 VKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYR 243

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            |.|.:..::|.|||..||||||||:|:||||||.||||||||||||||||||||||||:|..|||
Mouse   244 HGYDLSSAISVLVPLGGPVLCRDEMEEWSASEACLFEEALEKYGKDFNDIRQDFLPWKSLTSIIE 308

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGT--TNGSTDLS 453
            ||||||||||||||||:||.|||.||||||||.|:.......:|:....|..||.  |......:
Mouse   309 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISSSNGKAGTVNGAVGTQFQPQSA 373

  Fly   454 SNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAAS 518
            ..|:.||||..|:|.||.|....:...|||.:||.||::||.:|..|     :.|.:|..|..|.
Mouse   374 LLGRACESCYATQSHQWYSWGPPNMQCRLCATCWLYWKKYGGLKMPT-----QSDEEKSPSPTAE 433

  Fly   519 TPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAI-S 582
            .|.|                                           ::|::|...|  |:.: :
Mouse   434 DPRA-------------------------------------------RSHMSRQALQ--GMPVRN 453

  Fly   583 SGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQA 647
            :|||:..:|||.||:|.|...|::||.:|:|.::.::|||:...|||...::.|:.:|     .|
Mouse   454 TGSPKSAVKTRQAFFLRTTYFTKIARQVCKSTLRLRQAARRPFVAINYAAIRAEYADR-----HA 513

  Fly   648 EIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPK--PPKAPDGSLVY 710
            |:.                    |:|        :.:...:.||..::.:.:  |.|.|:
Mouse   514 ELS--------------------GSP--------LKSRSTRKPLSCIIGYLEIHPAKKPN----- 545

  Fly   711 DRVPNKSPDVVAVPADKELTIIPTQATSTI---RKRAHEDQQLNGTEVTIVPS 760
               ..:||..:..||.|.:...|...:.:|   |..:|.: .|:.:::.:|.|
Mouse   546 ---VIRSPPSLQTPATKRMLAAPNHTSLSILGKRNYSHHN-GLDASKIRMVNS 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	116/249 (47%)
		ELM2	232..284	CDD:279754	28/51 (55%)
		SANT_MTA3_like	352..397	CDD:212559	39/44 (89%)
		SANT	353..398	CDD:197842	40/44 (91%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
Mta3	XP_006523574.1	BAH_MTA	3..170	CDD:240060	116/248 (47%)
		ELM2	150..201	CDD:366648	28/50 (56%)
		SANT_MTA3_like	270..315	CDD:212559	39/44 (89%)
		ZnF_GATA	376..427	CDD:214648	22/55 (40%)
		MTA_R1	460..536	CDD:375062	26/108 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838073
Domainoid	1	1.000	61	1.000	Domainoid score	I10395
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I957
Isobase	1	0.950	-	0	Normalized mean entropy	S4979
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm43128
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	O	PTHR10865
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3578
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740