DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and Mta1

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_006515481.1	Gene:	Mta1 / 116870	MGIID:	2150037	Length:	734	Species:	Mus musculus

Alignment Length:	918	Identity:	396/918 - (43%)
Similarity:	502/918 - (54%)	Gaps:	222/918 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::||||||||||||...|||||||:|||||||:.:.|:.|||||
Mouse     1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKH--- 62

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
                                       |.|.....|             |.|:.||..|......
Mouse    63 ---------------------------ATLSVCYRA-------------GPGADTGEEGEVEEEV 87

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
            .|.....                      |..|.::|::|||||||||:||:|||.|||||||||
Mouse    88 ENPEMVD----------------------LPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTL 130

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            |||||||:|||.::|.|||.||:||.||||||||||||||:|||.||...||:...|.|...:||
Mouse   131 LNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKEGEEDGRDQSKLE 195

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            :.||...:.|.|::|||||||:||:|||||||||||||:|||||||||||||||||||||:.|||
Mouse   196 TKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHK 260

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            :.|.|.:::|:|||..||||||||:|:||||||||||||||||||||.||:|||||||:|..|||
Mouse   261 NIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIE 325

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYN--NNGKGNGTSTKAGGGIYNGT-TNGSTDL 452
            ||||||||||||||||:||.|||.||||||||.||  |..:.:.:|.||  .:.||| |.|.:
Mouse   326 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISASSVKA--TVVNGTGTPGQS-- 386

  Fly   453 SSNGKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAA 517
            ...|:.||||.||:|.||.|....:...|||.|||.||::||.:|..|:.| ||.....:::.:
Mouse   387 PGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLD-GERPGPNRNNMS- 449

  Fly   518 STPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGI-AI 581
                                                                      .||| |.
Mouse   450 ----------------------------------------------------------PHGIPAR 456

  Fly   582 SSGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQ 646
            |||||:..||||.||||||..:||:||.:||.|::|..|||.....||:..:|.|.|.|:...||
Mouse   457 SSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQ 521

  Fly   647 AEIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSF----PKPPKAPDGS 707
            :.                                |||....:.||.||:.:    |:||| ||
Mouse   522 SP--------------------------------LVLKQVVRKPLEAVLRYLETHPRPPK-PD-- 551

  Fly   708 LVYDRVPNKSPDVV---AVPADKELTIIPTQATSTIRKRAHEDQQLNGTEVTIV-PS-----GPP 763
                  |.||...|   ..|| |...:|...:.:.:.||::|  |.||.:|.:. ||     ..|
Mouse   552 ------PVKSSSSVLSSLTPA-KSAPVINNGSPTILGKRSYE--QHNGVDVDVFSPSLSCSWALP 607

  Fly   764 AKRPNKDPMPSHCPSPEQFAAMMAASGQPLSRHH-------LNGKQ---KIAQMARGGN---GRK 815
            .....:..|||.       ...:..:....:||.       ||||.   |: ::.|||:   .::
Mouse   608 GNMKKRLLMPSR-------GTYLGLANHGQTRHMGPSRNLLLNGKSYPTKV-RLIRGGSLPPVKR 664

  Fly   816 QVISWMDAPDDVYFRANDTHKKTRKILSAVDLRRAARKPWR--------TLPIKPAAPEPSSRPI 872
            :.::|:||||||::.|.:..:|.||:||:.:.:||||:|::        .||::|..|.|.:
Mouse   665 RRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVN--- 726

  Fly   873 ESQIVILD 880
            :..|||.|
Mouse   727 DEPIVIED 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	117/249 (47%)
		ELM2	232..284	CDD:279754	26/51 (51%)
		SANT_MTA3_like	352..397	CDD:212559	38/44 (86%)
		SANT	353..398	CDD:197842	39/44 (89%)
		ZnF_GATA	458..508	CDD:238123	25/49 (51%)
Mta1	XP_006515481.1	BAH_MTA	3..188	CDD:240060	117/249 (47%)
		ELM2	167..219	CDD:366648	26/51 (51%)
		SANT_MTA3_like	287..332	CDD:212559	38/44 (86%)
		ZnF_GATA	388..441	CDD:214648	26/53 (49%)
		MTA_R1	464..541	CDD:375062	36/108 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838075
Domainoid	1	1.000	110	1.000	Domainoid score	I6323
eggNOG	1	0.900	-	-		E1_KOG3554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3442
Inparanoid	1	1.050	596	1.000	Inparanoid score	I957
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm43128
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	LDO	PTHR10865
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760