DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTA1-like and Mta3

DIOPT Version :9

Sequence 1:	NP_001262293.1	Gene:	MTA1-like / 40693	FlyBaseID:	FBgn0027951	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	XP_038934036.1	Gene:	Mta3 / 100362346	RGDID:	1306803	Length:	637	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	329/764 - (43%)
Similarity:	425/764 - (55%)	Gaps:	185/764 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATNMYRVGDYVYVETTPNSPYLIRRIEELNKNQTGNVEAKVMCFYRRRDLPNPLVQLADKHQLA 65
            ||.||||||||||.|.:.::||||||||||||..:|||||||:|||||||:.|.|:.|||||...
  Rat     1 MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKE 65

  Fly    66 TAEDSPLATKLKKTWLRTPVSEEQAAQAVLDPSIAALDEERTSPTQTSGGGGSATGNSGSNSSGT 130
            |.|:|           .|.|..:
  Rat    66 TEEES-----------ETTVEAD------------------------------------------ 77

  Fly   131 SNNNSSSTAIGGGAGGSGGAGGDAEKGEALTSKQRYQIKHRELFLSRQVESIPATQIRGKCSVTL 195
                                         ||.||::|:||||||||||.||:|||.|||||||.|
  Rat    78 -----------------------------LTEKQKHQLKHRELFLSRQYESLPATHIRGKCSVAL 113

  Fly   196 LNETESLQSYLNKDDTFFYCLVFDPNQKTLLADKGEIRVGSRYQCDIPAKLKDTATDDRKLEELE 260
            ||||||:.|||:|:|||||.||:||:.|||||||||||||.:||.|||..|.:..:|:|:..:||
  Rat   114 LNETESVLSYLDKEDTFFYSLVYDPSVKTLLADKGEIRVGPKYQADIPDVLPEGDSDEREQSKLE 178

  Fly   261 SLVWTPEHSLTDRKIDQFLVVSRSIGTFARALDCSSSVKQPSLHMSAAAASRDITLFHAMNILHK 325
            ..||.|...||||:|||||||:|::|||||||||||||:|||||||||||||||||||||:.|::
  Rat   179 VKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYR 243

  Fly   326 HEYSIEESMSSLVPSTGPVLCRDEIEDWSASEANLFEEALEKYGKDFNDIRQDFLPWKTLKQIIE 390
            |.|.:..::|.|||..||||||||:|:||||||:||||||||||||||||||||||||:|..|||
  Rat   244 HGYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIE 308

  Fly   391 YYYMWKTTDRYVQQKRVKAVEAELKLKQVYIPQYNNNGKGNGTSTKAGGGIYNGTTNGSTDLSSN 455
            ||||||||||||||||:||.|||.||||||||.|:.......:|:....|..||.........|.
  Rat   309 YYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISSSNGKAGTVNGAVGTPFQPQSA 373

  Fly   456 --GKPCESCGTTKSSQWNSVSSGHSTSRLCLSCWEYWRRYGSMKSATKGDAGEGDAKKKSSSAAS 518
              |:.||||..|:|.||.|....:...|||.:||.||::||.:|..|     :.|.:|..|.||.
  Rat   374 LLGRACESCYATQSHQWYSWGPPNMQCRLCATCWLYWKKYGGLKMPT-----QTDEEKAPSPAAE 433

  Fly   519 TPTATLAGLATTPTAVVDLNDDEKISDLTNRQLHRCSIVNCGKEFKLKTHLARHYAQAHGIAI-S 582
            .|                                           ::::||:|...|  |:.: :
  Rat   434 DP-------------------------------------------RVRSHLSRQALQ--GMPVRN 453

  Fly   583 SGSPRPIMKTRTAFYLHTNPMTRVARAICRSIVKPKKAARQSAYAINAMLVKQEFTNRISGKSQA 647
            :|||:..:|||.||:|||...|::||.:|::.::.::|||:...|||...::.|:.:|     .|
  Rat   454 TGSPKSAVKTRQAFFLHTTYFTKIARQVCKNTLRLRQAARRPFVAINYAAIRAEYADR-----HA 513

  Fly   648 EIKKLLLLKPKDRGSVTKIANRLGAPGSGPHEWLVLTPKDKMPLPAVVSFPK--PPKAPDGSLVY 710
            |:.                    |:|        :.:...:.||..::.:.:  |.|.|:
  Rat   514 ELS--------------------GSP--------LKSKSTRKPLSCIIGYLEIHPAKKPN----- 545

  Fly   711 DRVPNKSPDVVAVPADKELTIIPTQATSTI---RKRAHEDQQLNGTEVT 756
               ..:||..:..|..|.:...|...:.:|   |..:|.    ||.:.:
  Rat   546 ---VIRSPPSLQTPTTKRMLTTPNHTSLSILGKRNYSHH----NGLDAS 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTA1-like	NP_001262293.1	BAH_MTA	3..253	CDD:240060	115/249 (46%)
		ELM2	232..284	CDD:279754	28/51 (55%)
		SANT_MTA3_like	352..397	CDD:212559	39/44 (89%)
		SANT	353..398	CDD:197842	40/44 (91%)
		ZnF_GATA	458..508	CDD:238123	20/49 (41%)
Mta3	XP_038934036.1	BAH_MTA	3..170	CDD:240060	115/248 (46%)
		ELM2	150..201	CDD:396160	28/50 (56%)
		SANT_MTA3_like	270..315	CDD:212559	39/44 (89%)
		ZnF_GATA	376..421	CDD:214648	21/49 (43%)
		MTA_R1	460..536	CDD:407344	26/108 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341853
Domainoid	1	1.000	110	1.000	Domainoid score	I6170
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I965
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D347549at33208
OrthoFinder	1	1.000	-	-		FOG0002092
OrthoInspector	1	1.000	-	-		otm45196
orthoMCL	1	0.900	-	-		OOG6_103523
Panther	1	1.100	-	-	O	PTHR10865
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1382
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900