DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12170 and CEM1

DIOPT Version :9

Sequence 1:	NP_649565.1	Gene:	CG12170 / 40692	FlyBaseID:	FBgn0037356	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_010983.2	Gene:	CEM1 / 856790	SGDID:	S000000863	Length:	442	Species:	Saccharomyces cerevisiae

Alignment Length:	449	Identity:	174/449 - (38%)
Similarity:	264/449 - (58%)	Gaps:	57/449 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RRVVVTGSGAVTPLGNNGPDSWRRILAGESAISRLSA----------EFKGLPCQV-AAQIPREN 77
            ||||:||.|.|||||.:..:||..:|:.::.::.:::          ..|.:|..: ..:|| ||
Yeast     3 RRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTPITSLPNYNEDYKLREKSIPSTITVGKIP-EN 66

  Fly    78 LQLDQH------LTKSDIKLMSPATQLAVLAAEEAL-STGKLCPKQLSEE----ELERFGVCVGM 131
            .|.:..      .|..|.:..|...:||:....||| :.|.|.|..::..    .|:.||..:|.
Yeast    67 FQNENSAINKLLFTSQDERRTSSFIKLALRTTYEALHNAGLLNPNDITINTSLCNLDHFGCLIGS 131

  Fly   132 GMFDLAEVYGAWNQLQRGYNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTACATGAHALGD 196
            |:..:.::|....|......|::|:|||::|.:||.|::|::..|||.:||||||||||.:::||
Yeast   132 GIGSIQDIYQTSLQFHNDNKRINPYFVPKILTNMAAGNVSIKFNLRGLSHSVSTACATGNNSIGD 196

  Fly   197 AMRFIRSGDADLMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGEGAA 261
            |..|||.|..|:.:||:.|..:.|||:|||.|.::::|  |.    .|||||..|.|||:|||..
Yeast   197 AFNFIRLGMQDICVAGASETSLHPLSLAGFIRAKSITT--NG----ISRPFDTQRSGFVLGEGCG 255

  Fly   262 VLLLEELEHARARGAPILAEILGYGLSGDAYHITSPSDDGAGATLAMKRAIQDAGIAPEDVTYVN 326
            ::::|.||||:.|.|.|::|::|||||.||.|||||..||.||..|::.|::.|.:.|.||.|||
Yeast   256 MIVMESLEHAQKRNANIISELVGYGLSSDACHITSPPADGNGAKRAIEMALKMARLEPTDVDYVN 320

  Fly   327 AHATSTPTGDRIESHAI------GRVFGAHTPQVRVSSTKGAHGHLLGSSGNLEALFVVLACANN 385
            ||||||..||:.|..|:      ||   :.:..:.:||.|||.|||||::|.:|::|.:.:..::
Yeast   321 AHATSTLLGDKAECLAVASALLPGR---SKSKPLYISSNKGAIGHLLGAAGAVESIFTICSLKDD 382

  Fly   386 KLPPSINIEHLDVDVNVVTKATDWSADQ------------KRRVALKNSFGFGGTNASL 432
            |:|.::|::      ||:|...: .||:            ..:.||.|||||||.|.||
Yeast   383 KMPHTLNLD------NVLTLENN-EADKLHFIRDKPIVGANPKYALCNSFGFGGVNTSL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12170	NP_649565.1	PRK07314	23..437	CDD:235987	174/449 (39%)
CG12170	NP_649565.1	KAS_I_II	24..434	CDD:238430	174/449 (39%)
CEM1	NP_010983.2	KAS_I_II	3..436	CDD:238430	174/449 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344402
Domainoid	1	1.000	168	1.000	Domainoid score	I791
eggNOG	1	0.900	-	-		E1_COG0304
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5820
Inparanoid	1	1.050	286	1.000	Inparanoid score	I540
Isobase	1	0.950	-	0	Normalized mean entropy	S1147
OMA	1	1.010	-	-		QHG53767
OrthoFinder	1	1.000	-	-		FOG0002908
OrthoInspector	1	1.000	-	-		oto99285
orthoMCL	1	0.900	-	-		OOG6_100752
Panther	1	1.100	-	-	LDO	PTHR11712
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R883
SonicParanoid	1	1.000	-	-		X2728
TreeFam	0	0.000	Not matched by this tool.
	15	14.780