DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12170 and OXSM

DIOPT Version :9

Sequence 1:	NP_649565.1	Gene:	CG12170 / 40692	FlyBaseID:	FBgn0037356	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_060367.1	Gene:	OXSM / 54995	HGNCID:	26063	Length:	459	Species:	Homo sapiens

Alignment Length:	446	Identity:	236/446 - (52%)
Similarity:	303/446 - (67%)	Gaps:	23/446 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CTVLVRQTRSL-----STPSGR--RRVVVTGSGAVTPLGNNGPDSWRRILAGESAI-SRLSAEFK 63
            |:.|.:|.||.     :.|..|  ||||:||.|.|||||......|.|::.|||.| |.:..|:|
Human    18 CSRLCQQLRSKRKFFGTVPISRLHRRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYK 82

  Fly    64 GLPCQVAAQIPR--ENLQLDQH--LTKSDIKLMSPATQLAVLAAEEALSTGKLCPKQLSEEELER 124
            .:||.|||.:||  :..|.::.  ::|||||.||..|.:|:.|||.|:......|:  ||.:...
Human    83 SIPCSVAAYVPRGSDEGQFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQ--SEADQVA 145

  Fly   125 FGVCVGMGMFDLAEVYG--AWNQLQRGYNRVSPFFVPRLLPSMACGHISMRHGLRGPNHSVSTAC 187
            .||.:||||..| ||..  |.|...:|||:|||||||::|.:||.|.:|:|:.|:||||:|||||
Human   146 TGVAIGMGMIPL-EVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTAC 209

  Fly   188 ATGAHALGDAMRFIRSGDADLMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRD 252
            .|||||:||:.|||..||||:|:||..::||.|||:|||.|.|||||  |.:|.:|.|||...||
Human   210 TTGAHAVGDSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRD 272

  Fly   253 GFVMGEGAAVLLLEELEHARARGAPILAEILGYGLSGDAYHITSPSDDGAGATLAMKRAIQDAGI 317
            |||||||||||:|||.|||..|.|.|.||:|||||||||.|||:|..:|.||...|..|::|||:
Human   273 GFVMGEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGV 337

  Fly   318 APEDVTYVNAHATSTPTGDRIESHAIGRVFGAHTPQVRVSSTKGAHGHLLGSSGNLEALFVVLAC 382
            .||:::|:||||||||.||..|:.||..:|..|...:.|||||||.|||||::|.:||.|..|||
Human   338 QPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAFTTLAC 402

  Fly   383 ANNKLPPSINIE--HLDVDVNVV-TKATDWSADQKRRVALKNSFGFGGTNASLCIA 435
            ...||||::|::  ..:.|:|.| .||.:|.. :||.:.|.||||||||||:||||
Human   403 YYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKT-EKRFIGLTNSFGFGGTNATLCIA 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12170	NP_649565.1	PRK07314	23..437	CDD:235987	230/425 (54%)
CG12170	NP_649565.1	KAS_I_II	24..434	CDD:238430	226/419 (54%)
OXSM	NP_060367.1	fabF	42..455	CDD:274452	225/418 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149653
Domainoid	1	1.000	243	1.000	Domainoid score	I2220
eggNOG	1	0.900	-	-		E1_COG0304
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5820
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1852
Isobase	1	0.950	-	0	Normalized mean entropy	S1147
OMA	1	1.010	-	-		QHG53767
OrthoDB	1	1.010	-	-		D1014523at2759
OrthoFinder	1	1.000	-	-		FOG0002908
OrthoInspector	1	1.000	-	-		oto89186
orthoMCL	1	0.900	-	-		OOG6_100752
Panther	1	1.100	-	-	LDO	PTHR11712
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R883
SonicParanoid	1	1.000	-	-		X2728
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	17	16.790