DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12170 and FASN2

DIOPT Version :9

Sequence 1:	NP_649565.1	Gene:	CG12170 / 40692	FlyBaseID:	FBgn0037356	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001259986.1	Gene:	FASN2 / 117361	FlyBaseID:	FBgn0042627	Length:	2410	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	109/453 - (24%)
Similarity:	181/453 - (39%)	Gaps:	86/453 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VVVTGSGAVTPLGNNGPDSWRRILAGESAIS----RLSAEFKGLPCQVAAQIPRENLQLDQHLTK 86
            :|::|.....|..:|..:....:|.|...::    |..|...|||.::|.       ..|..|.|
  Fly    19 IVISGLSGKLPESSNIEEFKYNLLNGIDMVTDEPRRWEAGIYGLPERMAK-------MKDSDLEK 76

  Fly    87 SDIK----------LMSPATQLAVLAAEEALSTGKLCPKQLSEEELERFGVCVGMGMFDLAEVYG 141
            .|.|          ||.|..::.:....||:....:.|.||..   .|.||.:|:...:
  Fly    77 FDDKFFSVHQKQAELMDPCMRMLLELTHEAIIDAGINPVQLRG---SRTGVYIGLSFVE------ 132

  Fly   142 AWNQLQRGYNRVSPFFVPRLLPS-------------MACGHISMRHGLRGPNHSVSTACATGAHA 193
                        :...:|.:.||             |....||.....:||:..|.|||::...|
  Fly   133 ------------TEHEIPNMEPSSINGYCLTGCARAMFANRISYTFDFKGPSFIVDTACSSSLVA 185

  Fly   194 LGDAMRFIRSGDADLMLAGSGEACIDPLSIAGFCRLRALSTAFNDNPAVASRPFDKSRDGFVMGE 258
            |..|...:|:|..|..|.......:.|:....|.||..:|   :|.   :.:.||.:.:|:...:
  Fly   186 LNHAFADMRAGRCDYALVAGVNLILKPIFALQFLRLGIVS---HDG---SCKTFDAAANGYARAD 244

  Fly   259 GAAVLLLEELEHARARGAPILAEILGYGLSGDAYH---ITSPSDDGAGATLAMKRAIQDAGIAPE 320
            ..||:||:..:.|:.    :.|.||....:.|.:.   :|.|  ||......::....:.|:.|:
  Fly   245 TCAVVLLQRRKEAKR----VYASILNVRTNTDGFKEQGVTFP--DGRMQQALLEETYSEIGLNPD 303

  Fly   321 DVTYVNAHATSTPTGDRIESHAIGRVF---GAHTPQVRVSSTKGAHGHLLGSSGNLEALFVVLAC 382
            :|.||.||.:.||.||..|::.:...|   ...|| :.:.|.|...||...:||......:::|.
  Fly   304 EVVYVEAHGSGTPVGDDQEANMLSNFFCRPSRSTP-LLIGSVKSNMGHAEPASGVSALAKMIIAM 367

  Fly   383 ANNKLPPSINIEH--------LDVDVNVVTKATDWSADQKRRVALKNSFGFGGTNASLCIASY 437
            ....:|.:::...        ::..:.||.:...|   |...|.| |||||||.||.:.:.|:
  Fly   368 EEGIIPKNLHYRTPNPSVPALVEGKLKVVDRNLPW---QGGIVGL-NSFGFGGANAHVVLKSH 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12170	NP_649565.1	PRK07314	23..437	CDD:235987	108/451 (24%)
CG12170	NP_649565.1	KAS_I_II	24..434	CDD:238430	108/448 (24%)
FASN2	NP_001259986.1	PksD	15..1043	CDD:225858	109/453 (24%)
		PKS	18..423	CDD:238429	108/448 (24%)
		KAsynt_C_assoc	381..498	CDD:292814	16/50 (32%)
		Acyl_transf_1	518..835	CDD:298668
		hot_dog	875..1072	CDD:294345
		NADB_Rossmann	1263..>1429	CDD:304358
		PKS_ER	1471..1761	CDD:214840
		enoyl_red	1473..1761	CDD:176179
		KR_1_FAS_SDR_x	<1780..2018	CDD:187657
		PKS_PP	2031..>2083	CDD:214834
		Abhydrolase	2159..2408	CDD:304388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840