Protein Alignment CG31546 and HSDL2

DIOPT Version :10

• Sequence 1: NP_730973.1
• Gene: CG31546 / 40691
• FlyBaseID: FBgn0051546
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_115679.2
• Gene: HSDL2 / 84263
• HGNCID: 18572
• Length: 418
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 67/291 - (23%)
• Similarity: 106/291 - (36%)
• Gaps: 74/291 - (25%)

  Fly    12 SGKVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEPYGIAG------- 69
            :|..|.||||:.|||.|.|...:|.||.:.:..:..:....::........|...:.|
Human     9 AGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPCIV 73

  Fly    70 DLLKPPEIECIARKTTERYEGKLDVLVNGA-GIMPTGTLQSTELACFTHVMEANVRSGFYLTKLL 133
            |:....:|.....|..::: |.:|:|||.| .|..|.|| .|.......:|..|.|..:..:|..
Human    74 DVRDEQQISAAVEKAIKKF-GGIDILVNNASAISLTNTL-DTPTKRLDLMMNVNTRGTYLASKAC 136

  Fly   134 LPQLLQCK-GSIVNVSSVCGLRA--FPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVNAV----- 190
            :|.|.:.| ..|:|:|....|..  |....||.::|..:..:...:|.:...: :.|||:
Human   137 IPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGE-IAVNALWPKTA 200

  Fly   191 ----------NPG-----------------------------VIRTNLQKAGGMDE-QSYA---- 211
                      .||                             ||..|:.|..|::. ..||
Human   201 IHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFDVYAIKPG 265

  Fly   212 ------EFLEH-----SKKTHALGRIGEPKE 231
                  .||:.     |||..:.|.:.|.||
Human   266 HPLQPDFFLDEYPEAVSKKVESTGAVPEFKE 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31546	NP_730973.1	Rossmann-fold NAD(P)(+)-binding proteins	11..261	CDD:473865	67/291 (23%)
HSDL2	NP_115679.2	HSDL2_SDR_c	8..248	CDD:187663	53/241 (22%)
		SCP2	311..414	CDD:442486