Protein Alignment CG31546 and HSD17B14

DIOPT Version :10

• Sequence 1: NP_730973.1
• Gene: CG31546 / 40691
• FlyBaseID: FBgn0051546
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_057330.2
• Gene: HSD17B14 / 51171
• HGNCID: 23238
• Length: 270
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 90/274 - (32%)
• Similarity: 136/274 - (49%)
• Gaps: 47/274 - (17%)

  Fly     8 GLDFSGKVVLITGAASGIGAAAAEMFSKLGACLALVDREEEG-------------LICVMKRCMK 59
            |..::||||::||...||||.....|...||.:.:.|::|.|             ::|
Human     4 GTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILC------- 61

  Fly    60 MGHEPYGIAGDLLKPPEIECIARKTTERYEGKLDVLVNGAGIMPTGTL-QSTELACFTHVMEANV 123
                      |:.:..:::.:..:|..|: |:||.:||.||..|.... :.|....|..::|.|:
Human    62 ----------DVTQEDDVKTLVSETIRRF-GRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNL 115

  Fly   124 RSGFYLTKLLLPQLLQCKGSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVN 188
            ...:.||||.||.|.:.:|:::|:||:.|.......|.|..:|.||...|::||||..|.|||||
Human   116 LGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180

  Fly   189 AVNPGVIRTNLQKAGGMDEQSYAEFLEHSKKT-------HALGRIGEPKEVAAAICFLASELASF 246
            .::||.|.|.|.       :..|..:...:.|       ..|||:|:|.||.||..||||| |:|
Human   181 CISPGNIWTPLW-------EELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANF 237

  Fly   247 VTGVTLPVDGGKQV 260
            .||:.|.|.||.::
Human   238 CTGIELLVTGGAEL 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31546	NP_730973.1	Rossmann-fold NAD(P)(+)-binding proteins	11..261	CDD:473865	89/271 (33%)
HSD17B14	NP_057330.2	RDH_SDR_c	1..256	CDD:187638	90/274 (33%)