Protein Alignment CG31546 and RDH8

DIOPT Version :10

• Sequence 1: NP_730973.1
• Gene: CG31546 / 40691
• FlyBaseID: FBgn0051546
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 69/268 - (25%)
• Similarity: 109/268 - (40%)
• Gaps: 76/268 - (28%)

  Fly    14 KVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEP---YGIAG---DLL 72
            :.|||:|.:||||                           ::..:::.|:|   |.:..   ||.
Human     6 RTVLISGCSSGIG---------------------------LELAVQLAHDPKKRYQVVATMRDLG 43

  Fly    73 KPPEIECIARKTTER---------------------YEGKLDVLVNGAGIMPTGTLQSTELACFT 116
            |...:|..|.:...:                     .:|::|||||.||:...|.|:...||...
Human    44 KKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQ 108

  Fly   117 HVMEANVRSGFYLTKLLLPQLLQCK-GSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDL 180
            :|.:.|......|.|.:||.:.:.: |.||.:|||.||:.......|..||.|::.|..|||:.|
Human   109 NVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQL 173

  Fly   181 GPQGVRVNAVNPGVIRTNLQKAGGMDEQ-SYAEF---------------LEHSKKTHALGRIGE- 228
            ....:.::.|.||.:.|..:  |.:..| |.|||               |..|:|...  .:|:
Human   174 LQFNIFISLVEPGPVVTEFE--GKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFC--SVGQN 234

  Fly   229 PKEVAAAI 236
            |::|..||
Human   235 PQDVVQAI 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31546	NP_730973.1	Rossmann-fold NAD(P)(+)-binding proteins	11..261	CDD:473865	69/268 (26%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	69/268 (26%)