Protein Alignment CG31546 and HSD11B1

DIOPT Version :10

• Sequence 1: NP_730973.1
• Gene: CG31546 / 40691
• FlyBaseID: FBgn0051546
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_005516.1
• Gene: HSD11B1 / 3290
• HGNCID: 5208
• Length: 292
• Species: Homo sapiens
• Alignment Length: 187
• Identity: 60/187 - (32%)
• Similarity: 89/187 - (47%)
• Gaps: 22/187 - (11%)

  Fly    13 GKVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMG----HEPYGIAGDLLK 73
            ||.|::|||:.|||...|...:|:||.:.:..|.:|.|..|:..|:::|    |...|...|:
Human    34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDM-- 96

  Fly    74 PPEIECIARKTTERYEGKLDVLVNGAGIMPTGTLQSTELACF----THV---MEANVRSGFYLTK 131
                     ...|::..:...|:.|..::....:.:|.|..|    .||   ||.|..|...||.
Human    97 ---------TFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTV 152

  Fly   132 LLLPQLLQCKGSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVN 188
            ..||.|.|..||||.|||:.|..|:|.:.||:.||.|:|.|..|:..:.....|.|:
Human   153 AALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVS 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31546	NP_730973.1	Rossmann-fold NAD(P)(+)-binding proteins	11..261	CDD:473865	60/187 (32%)
HSD11B1	NP_005516.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	60/187 (32%)