Protein Alignment CG12171 and HSD17B8

DIOPT Version :10

• Sequence 1: NP_649563.1
• Gene: CG12171 / 40690
• FlyBaseID: FBgn0037354
• Length: 257
• Species: Drosophila melanogaster
• Sequence 2: NP_055049.1
• Gene: HSD17B8 / 7923
• HGNCID: 3554
• Length: 261
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 80/259 - (30%)
• Similarity: 128/259 - (49%)
• Gaps: 23/259 - (8%)

  Fly     5 KDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADINSES 69
            :..:.:||||.||||...||.||..|.  |:...:||:  ..|::.|...|.|..:......:.:
Human    10 RSALALVTGAGSGIGRAVSVRLAGEGA--TVAACDLDR--AAAQETVRLLGGPGSKEGPPRGNHA 70

  Fly    70 DVQGIVSATLAKHGRID-----------VLVNNAGILELGSIENTSLEQFDRVMNTNVRSLYQLT 123
            ..|..||...|....::           |:|:.|||.:...:.:.|.:.:|:|:..|::..:.:|
Human    71 AFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVT 135

  Fly   124 HLVTPELIKT--KGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNSVNPG 186
            ......|:..  :|:|:|:||:.|.....|...|..|||.|...|:..|.||...|:|.|||.||
Human   136 QAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPG 200

  Fly   187 VIITELQRRGGLDQEAYVKFLEHAKVTHALGRPGEVKEVAAAIAFLASDEASFSTGISLPVDGG 250
            .|.|.:.::  :.|:...|..|...:.| ||.|   ::||..:|||||:::.:.||.|:.|.||
Human   201 FIATPMTQK--VPQKVVDKITEMIPMGH-LGDP---EDVADVVAFLASEDSGYITGTSVEVTGG 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12171	NP_649563.1	Rossmann-fold NAD(P)(+)-binding proteins	4..254	CDD:473865	80/259 (31%)
HSD17B8	NP_055049.1	BKR_SDR_c	13..260	CDD:187594	80/256 (31%)